Automated analysis device

Patent metadata

Field	Value
Publication number	US-11761972-B2
Application number	US-201916964798-A
Country	US
Kind code	B2
Filing date	Jan 28, 2019
Priority date	Feb 20, 2018
Publication date	Sep 19, 2023
Grant date	Sep 19, 2023

Abstract

The objective of the present disclosure is to provide a technique for reducing a quantity of magnetic particles remaining on a reaction vessel wall surface in a cleaning step for reducing, in a stepwise manner, an amount of a magnetic particle solution in the reaction vessel. The automated analysis device according to the present disclosure causes an agitating mechanism to operate in such a way that a magnetic substance remaining on the wall surface of the vessel in the previous cleaning step is captured by a cleaning solution in the next cleaning step.

First claim

The invention claimed is:

1. An automated analysis device that measures a liquid sample containing magnetic particles and a substance to be measured, the automated analysis device comprising:
a magnetic separation device configured to separate the magnetic particles from the liquid sample;
an aspiration nozzle configured to aspirate the liquid sample from a vessel containing the liquid sample after the magnetic particles are separated;
a dispensing nozzle configured to dispense a cleaning solution to the vessel after the aspiration nozzle aspirates the liquid sample;
an agitating mechanism configured to perform agitating by rotating the vessel in which the cleaning solution is dispensed; and
a control unit configured to control the aspiration nozzle, the dispensing nozzle, and the agitating mechanism, wherein
after the magnetic separation device separates the magnetic particles from the liquid sample, the control unit controls the dispensing nozzle to dispense the cleaning solution and controls the agitating mechanism to rotate the vessel, so as to perform a cleaning step for removing the substance other than the magnetic particles from the liquid sample, and the cleaning step is performed a plurality of times on the same liquid sample,
the control unit reduces an amount of the cleaning solution each time the cleaning step is performed, and
the control unit is configured to causes the agitating mechanism to operate in such a way that a rotation speed of the vessel is increased each time the cleaning step is performed on the same liquid sample.

2. The automated analysis device according to claim 1 , wherein
the control unit is configured to cause the agitating mechanism to operate in such a way that a liquid surface of the cleaning solution when the agitating mechanism rotates the vessel is gradually made closer to vertical each time the cleaning step is performed on the same liquid sample.

3. The automated analysis device according to claim 1 , wherein
the control unit is configured to cause the agitating mechanism to operate in such a way that a liquid surface of the cleaning solution reaches the magnetic particles remaining on a wall surface of the vessel in the previous cleaning step each time the cleaning step is performed on the same liquid sample.

4. The automated analysis device according to claim 1 , wherein
the control unit is configured to reduce the rotation speed of the vessel more rapidly when the last cleaning step performed on the same liquid sample is completed than when the cleaning step performed before the last cleaning step is completed.

5. The automated analysis device according to claim 1 , wherein
before starting the cleaning step, the control unit is configured to control the dispensing nozzle to dispense an organic solvent to the vessel and controls the agitating mechanism to rotate the vessel, and thus a wall surface of the vessel is wetted with the organic solvent,
the control unit controls the aspiration nozzle to aspirates the organic solvent from the vessel after the wall surface of the vessel is wetted with the organic solvent, and
the control unit is configured to perform the cleaning step after the organic solvent is aspirated from the vessel.

Assignees

• Hitachi High Tech Corp

Inventors

• Inaba Tooru
• Hsu Ruochi
• Matsuoka Shinya
• Yokokawa Takeshi
• Ebihara Daisuke

Classifications

• B03C1/288 Primary

  disposed at the outer circumference of a recipient · CPC title

• G01N35/04 Primary

  Details of the conveyor system {(G01N35/021 - G01N35/028 take precedence)} · CPC title

• B03C1/01

  by addition of magnetic adjuvants · CPC title

• B03C1/284

  with associated cleaning means, e.g. retractable non-magnetic sleeve · CPC title

• B03C2201/18

  Magnetic separation whereby the particles are suspended in a liquid · CPC title