Apparatus and process for the automated chemical synthesis of compounds

Patent metadata

Field	Value
Publication number	US-11759760-B2
Application number	US-201716065940-A
Country	US
Kind code	B2
Filing date	Jan 10, 2017
Priority date	Jan 12, 2016
Publication date	Sep 19, 2023
Grant date	Sep 19, 2023

Abstract

Provided is an apparatus for the automated synthesis of at least one chemical compound including: at least one cartridge including at least one first compartment for providing at least one first reagent for the chemical synthesis of the at least one compound; at least one second compartment for providing at least one second reagent for the chemical synthesis of the at least one compound, and at least one third compartment for purifying the at least one synthesized compound; at least one reaction container for providing the compounds to be fed into at least one of the compartments of the cartridge and/or collecting the reaction product from at least one of the compartments of the cartridge; at least one solvent container at least two flow path selecting valves and at least one pump.

First claim

The invention claimed is:

1. An apparatus for the automated synthesis of at least one chemical compound, comprising:
(a) at least one solvent container for storing solvent system(s) used for at least one compartment of at least one cartridge, the at least one solvent container comprising at least one solvent reservoir, the at least one solvent reservoir having an inlet and an outlet,
(b) at least one reaction container for providing compound(s) to be fed into at least one of the compartments of the at least one cartridge and/or collecting reaction product(s) from at least one of the compartments of the at least one cartridge, the at least one reaction container having an inlet and an outlet;
(c) at least one first valve for selecting a liquid source from the at least one solvent reservoir or the at least one reaction container, the at least one first valve having an inlet connected to the outlet of the at least one solvent reservoir and the outlet of the at least one reaction container, and an outlet connected to a pump inlet;
(d) at least one pump comprising a first pump comprising the pump inlet for receiving liquid from the outlet of the first valve and a pump outlet connected to an inlet of at least one second valve for directing the liquid received from the at least one first valve to the at least one second valve either directly or through optional pump(s) of the at least one pump;
(e) the at least one second valve for directing the liquid received from the at least one pump to an inlet of at least one compartment of the at least one cartridge or the inlet of the at least one reaction container, the at least one second valve having the inlet for receiving the liquid from the at least one pump, and an outlet connected to the inlet of the at least one compartment of the at least one cartridge and the inlet of the at least one reaction container; and
(f) at least one cartridge comprising:
(i) at least one first compartment for providing at least one first reagent for the chemical synthesis of the at least one compound, the at least one first compartment having the inlet connected to the outlet of the at least one second valve, and an outlet connected to the at least one reaction container for passing a formed substrate-reagent intermediate product into the at least one reaction container;
(ii) at least one second compartment for providing at least one second reagent for the chemical synthesis of the at least one compound, the at least one second compartment having an inlet for receiving the substrate-reagent intermediate product from the outlet of the at least one reaction container, and an outlet connected to the inlet of the at least one reaction container for passing the formed reaction product into the at least one reaction container, and
(iii) at least one third compartment for purifying the at least one synthesized compound, the at least one third compartment having an inlet connected to the outlet of the reaction container for receiving the formed reaction product from the outlet of the first reaction container, and an outlet connected to the inlet of the at least one reaction container for passing the purified product into the at least one reaction container.

2. The apparatus according to claim 1 , wherein the at least one cartridge further comprises at least one fourth compartment for removing any (non-reacted) reagent material from the reaction product, the at least one fourth compartment(s) having an inlet connected to the outlet of the at least one reaction container for receiving the purified product from the at least one reaction container and an outlet connected to the inlet of the at least one reaction container for passing purified product into the at least one reaction container.

3. The apparatus according to claim 1 , wherein the inlet of each compartment is operatively linked to the at least one second valve that directs the liquid to one of the compartments in the cartridge.

4. The apparatus according to claim 1 , wherein the reaction container is any vessel capable of containing or storing the reactants, intermediates or products from the compartments.

5. The apparatus according to claim 1 , further comprising at least one stirring unit.

6. The apparatus according to claim 1 , further comprising at least one heating unit, at least one stirring unit and at least one microcontroller, the microcontroller being configured for operating or controlling the at least one first valve, the at least one second valve, the at least one pump, the at least one heating unit and the at least one stirring unit.

7. The apparatus according to claim 1 , further comprising at least one user interface accessible via touch-screen or push-buttons to start the process.

8. The apparatus according to claim 1 , wherein
the at least one first compartment comprises the at least one first reagent as at least one immobilized reagent;
the at least one second compartment comprises at least one catalyst as the at least one second reagent;
the at least one third compartment comprises at least one scavenging matrix for removing the at least one catalyst from the reaction product, and
wherein the apparatus further comprises at least one fourth compartment comprising at least one ion exchange support for purifying the reaction product.

9. The apparatus according to claim 8 , wherein the at least one third compartment of the at least one cartridge comprises at least one scavenging matrix for removing the at least one catalyst selected from a group comprising polymer-supported thiourea, polymer-supported trisamine and silica-supported trisamine.

10. The apparatus according to claim 8 , wherein the at least one fourth compartment of the at least one cartridge comprises an ion exchange resin or a silica supported ion exchange material for purifying the reaction product.

11. The apparatus according to claim 1 , further comprising a first purification compartment comprising an inlet configured for receiving the substrate-reagent intermediate product from the outlet of the at least one reaction container and configured for passing a purified product into the inlet of the at least one reaction container prior to passing the purified product into the at least one second compartment.

12. An apparatus for the automated synthesis of at least one chemical compound, comprising:
(a) at least one solvent container for storing solvent system(s) used for at least one compartment of at least one cartridge, the at least one solvent container comprising at least one solvent reservoir, the at least one solvent reservoir having an inlet and an outlet,
(b) at least one reaction container for providing compound(s) to be fed into at least one of the compartments of the at least one cartridge and/or collecting reaction product(s) from at least one of the compartments of the at least one cartridge, the at least one reaction container having an inlet and an outlet;
(c) at least one first valve for selecting a liquid source from the at least one solvent reservoir or the at least one reaction container, the at least one first valve having an inlet connected to the outlet of the at least one solvent reservoir and the outlet of the at least one reaction container, and an outlet connected to a pump inlet;
(d) at least one pump comprising a first pump comprising the pump inlet for receiving liquid from the outlet of the first valve and a pump outlet connected to an inlet of at least one second valve for directing the liquid received from the at least one first valve to the at least one second valve either directly or through optional pump(s) of the at least one pump;
(e) the at least one second valve for directing the li

Assignees

• Eth Zuerich

Inventors

• Bode Jeffrey William
• Wanner Benedikt Matthias
• Chen Kuang-Yen
• Pattabiraman Vijaya
• Nichols Paula Louise

Classifications

• B01J19/004 Primary

  Multifunctional apparatus for automatic manufacturing of various chemical products (sequential reactions B01J19/0046) · CPC title

• B01J20/22

  comprising organic material · CPC title

• B01J20/26

  Synthetic macromolecular compounds · CPC title

• B01J47/024

  where the ion-exchangers are in a removable cartridge · CPC title

• C07D213/36

  Radicals substituted by singly-bound nitrogen atoms (nitro radicals C07D213/26) · CPC title