Adaptive system for blood fluid removal

Patent metadata

Field	Value
Publication number	US-11759557-B2
Application number	US-202017034250-A
Country	US
Kind code	B2
Filing date	Sep 28, 2020
Priority date	Apr 29, 2011
Publication date	Sep 19, 2023
Grant date	Sep 19, 2023

Abstract

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

First claim

What is claimed is:

1. A method carried out by a blood fluid removal system, comprising:
storing a second data in a most effective to date data set; wherein the second data is data regarding system parameters employed in a first blood fluid removal session of a patient; and wherein a first data is data regarding the patient, the first data including one or more of a physiological parameter and time since last blood fluid removal session prior to the first blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate;
storing the second data in a least effective to date data set;
determining whether at least one physiological parameter in a third data is closer to a target value than the first data; and replacing the data in the most effective to date data set with a fourth data if the third data is closer to the target value than the first data;
wherein the third data is data regarding the patient, the data including one or more of a physiological parameter and time since last blood fluid removal session prior to a second blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate; and wherein the fourth data is data regarding system parameters employed in the second blood fluid removal session of the patient;
determining whether at least one physiological parameter in the third data is further from a target value than the first data; and replacing the data in the least effective to date data set with the fourth data if the third data is further from the target value than the first data; and
initiating a subsequent blood fluid removal session; wherein the subsequent blood fluid removal session employs the system parameters in the most effective to date data set; and wherein the step of initiating the subsequent blood fluid removal session comprises removing fluid from blood of a patient and returning the blood of the patient to the patient.

2. The method of claim 1 , wherein the physiological parameter is selected from blood pressure and/or heart rate.

3. The method of claim 1 , wherein the physiological parameter is selected from pH and/or concentration of an electrolyte.

4. The method of claim 3 , wherein the electrolyte is potassium.

5. The method of claim 1 , wherein the system parameters comprise one or more of fluid removal rate and dialysate concentration of one or more electrolyte.

6. The method of claim 5 , wherein the electrolyte is potassium.

7. A blood fluid removal system, comprising:
a blood fluid removal medium configured to remove blood from a patient, wherein blood enters the medium, fluid is removed from the blood, and blood exits the medium;
one or more control elements configured to control (i) the rate at which the medium removes fluid from the blood or (ii) the concentration of electrolytes or pH in the blood that exits the medium;
one or more sensors configured to monitor one or more physiological parameter of the patient;
an input configured to allow entry of data regarding patient or system parameters; and
control electronics comprising memory and a processor, wherein the control electronics are in operable communication with the one or more sensors and are operably coupled to the one or more control elements and the input,
wherein the control electronics are configured to carry out a method of:
storing a second data in a most effective to date data set; wherein the second data is data regarding system parameters employed in a first blood fluid removal session of a patient; and
wherein a first data is data regarding the patient, the first data including one or more of a physiological parameter and time since last blood fluid removal session prior to the first blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate;
storing the second data in a least effective to date data set;
determining whether at least one physiological parameter in a third data is closer to a target value than the first data; and replacing the data in the most effective to date data set with a fourth data if the third data is closer to the target value than the first data;
wherein the third data is data regarding the patient, the data including one or more of a physiological parameter and time since last blood fluid removal session prior to a second blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate; and wherein the fourth data is data regarding system parameters employed in the second blood fluid removal session of the patient;
determining whether at least one physiological parameter in the third data is further from a target value than the first data; and replacing the data in the least effective to date data set with the fourth data if the third data is further from the target value than the first data; and
initiating a subsequent blood fluid removal session; wherein the subsequent blood fluid removal session employs the system parameters in the most effective to date data set; and wherein the step of initiating the subsequent blood fluid removal session comprises conveying blood from the patient to the blood fluid removal medium; removing fluid from the blood, and returning the blood to the patient.

8. The system of claim 7 , wherein the blood fluid removal medium and the control electronics are housed within a blood fluid removal device.

9. The system of claim 7 further comprising a computer readable medium, wherein the computer readable medium comprises instructions that cause the control electronics to carry out the method.

10. The system of claim 7 , wherein the physiological parameter is selected from blood pressure and/or heart rate.

11. The system of claim 7 , wherein the physiological parameter is selected from pH and/or concentration of an electrolyte.

12. The system of claim 11 , wherein the electrolyte is potassium.

13. The system of claim 7 , wherein the system parameters comprise one or more of fluid removal rate and dialysate concentration of one or more electrolyte.

14. The system of claim 13 , wherein the electrolyte is potassium.

15. A blood fluid removal system comprising:
a blood fluid removal medium configured to remove blood from a patient, wherein blood enters the medium, fluid is removed from the blood, and blood exits the medium;
one or more control elements configured to control (i) the rate at which the medium removes fluid from the blood or (ii) the concentration of electrolytes or pH in the blood that exits the medium;
one or more sensors configured to monitor one or more physiological parameter of the patient; wherein at least one physiological parameter of the patient is measured in a dialysate;
an input configured to allow entry of data regarding patient or system parameters; and
control electronics comprising memory and a processor, wherein the control electronics are in operable communication with the one or more sensors and are operably coupled to the one or more control elements and the input,
wherein the control electronics are configured to:
receive first data regarding a patient, the data including one or more of a physiological parameter and time since last blood fluid removal session prior to a first blood fluid removal session of the patient;
receive second data regarding system parameters employed in the first blood fluid removal session of the patient;
determine, based on the first and second received data, whether at least one physiological parameter of the patient improved as a result of the system parameters employed

Assignees

• Medtronic Inc
• Mozarc Medical Us Llc

Inventors

• Gerber Martin
• Burnes John
• Lyu Suping
• Manda Venkatesh R
• Pudil Bryant

Classifications

• A61B5/6866 Primary

  Extracorporeal blood circuits, e.g. dialysis circuits · CPC title

• A61M1/1603 Primary

  Regulation parameters · CPC title

• A61M1/1601

  Control or regulation · CPC title

• A61M1/3609

  Physical characteristics of the blood, e.g. haematocrit, urea · CPC title

• A61B5/0031

  Implanted circuitry · CPC title