Double-layered denture comprising nanoparticles

Patent metadata

Field	Value
Publication number	US-11759403-B2
Application number	US-202017115237-A
Country	US
Kind code	B2
Filing date	Dec 8, 2020
Priority date	Dec 8, 2020
Publication date	Sep 19, 2023
Grant date	Sep 19, 2023

Abstract

Base material arrangements having at least two layers can accommodate the addition of antifungal material (nanofiller), such as in denture base resin without significantly compromising the mechanical properties and/or translucency of the base material arrangements. Antifungal agents such as nanosilver and nanozirconia can be used to modify a surface layer of the material arrangements, such as the denture base, to overcome certain known shortcomings of the modified materials, e.g., typical acrylic resins containing nanosilver and nanozirconia.

First claim

The invention claimed is:

1. A dental restoration base material, comprising:
a first layer comprising at least 90 wt. %, relative to total first layer weight, of a cured first composition comprising, prior to curing, a first (meth)acrylic polymer and a first (meth)acrylic monomer; and
a surface layer comprising at least 90 wt. %, relative to total surface layer weight, of a cured second composition comprising, prior to curing, a second (meth)acrylic polymer, a second (meth)acrylic monomer, and
0.45 to 0.55 wt. % of antimicrobial nanoparticles, relative to a total surface layer weight,

wherein no gradient in antimicrobial nanoparticle content and no continuous bulk containing the antimicrobial nanoparticles is present between the first and surface layers,
wherein the first layer is free of the antimicrobial nanoparticles,
wherein the antimicrobial nanoparticles are selected from silver nanoparticles and zirconium dioxide nanoparticles, and
wherein the material has a flexural strength in a range of 78 to 87 MPa, a translucency parameter in a range of 6.5 to 13, and a surface roughness in a range of 0.13 to 0.2 μm.

2. The material of claim 1 , wherein the silver nanoparticles have an average particle size of 5 to 40 nm.

3. The material of claim 1 , wherein the zirconium dioxide nanoparticles have an average particle size of 20 to 60 nm.

4. The material of claim 1 , wherein the antimicrobial nanoparticles comprise no more than 0.1 wt. % organic compounds, relative to the total material weight.

5. The material of claim 1 , wherein the surface layer directly contacts the first layer on at least portions of the first layer.

6. The material of claim 1 , arranged such that, in operation, the surface layer is configured to contact oral fluids and to shield any layers below the surface layer, including the first layer, from the oral fluids.

7. The material of claim 1 , wherein the surface layer has a thickness no more than 20% that of a total material thickness.

8. The material of claim 1 , wherein the surface layer has a thickness of 100 to 3,000 μm.

9. The material of claim 1 , wherein the first (meth)acrylic polymer and the second (meth)acrylic polymer each comprise at least 90 wt. % poly(methyl methacrylate).

10. The material of claim 1 , wherein the first (meth)acrylic monomer and the second (meth)acrylic monomer each comprise at least 90 wt. % methyl methacrylate.

11. The material of claim 1 , wherein the first (meth)acrylic polymer and the second (meth)acrylic polymer are the same,
wherein the first (meth)acrylic monomer and the second (meth)acrylic monomer are the same, and
wherein the first and the second (meth)acrylic monomer are suitable to form the same polymer as the first and the second (meth)acrylic polymer.

12. The material of claim 1 , which is suitable to reduce Candida adhesion to a dental prosthesis by at least 10%, relative to materials comprising the first layer alone.

13. A denture, comprising the material of claim 1 .

14. A method of preventing or reducing adhesion of a microorganism to a dental restoration, the method comprising inserting into an oral cavity of a subject in need thereof the dental restoration comprising the material of claim 1 ; and maintaining the dental restoration in the oral cavity for at least 3 hours.

15. The method of claim 14 , wherein the microorganism is a Candida species of fungus.

16. A method of making the dental restoration base material of claim 1 , the method comprising:
prepolymerizing the first composition comprising the first (meth)acrylic monomer and the first (meth)acrylic polymer, to obtain a first viscous composition;
conforming the first viscous composition into a dental mold;
prepolymerizing the second composition comprising the second (meth)acrylic monomer, 0.45 to 0.55 wt. %, relative to a total second composition weight, of the antimicrobial nanoparticles, and the second (meth)acrylic polymer, to obtain a second viscous composition;
conforming the second viscous composition into the dental mold over the first viscous composition;
polymerizing the first and second viscous compositions in the dental mold, thereby forming the dental restoration base material.

17. The material of claim 1 , wherein the surface layer comprises about 0.5 wt. % of the antimicrobial nanoparticles, relative to a total surface layer weight.

18. A dental restoration base material, comprising:
a first layer comprising at least 90 wt. %, relative to total first layer weight, of a cured first composition comprising, prior to curing, a first (meth)acrylic polymer and a first (meth)acrylic monomer; and
a surface layer comprising at least 90 wt. %, relative to total surface layer weight, of a cured second composition comprising, prior to curing, a second (meth)acrylic polymer, a second (meth)acrylic monomer, and
0.5 wt. % of silver nanoparticles, relative to a total surface layer weight, wherein no gradient in silver nanoparticles content and no continuous bulk containing the silver nanoparticles is present between the first and surface layers,
wherein the first layer is free of the silver nanoparticles, and
wherein the material has a flexural strength in a range of 78 to 82 MPa, a translucency parameter in a range of 6.5 to 7.5, and a surface roughness in a range of 0.18 to 0.2 μm.

19. A dental restoration base material, comprising:
a first layer comprising at least 90 wt. %, relative to total first layer weight, of a cured first composition comprising, prior to curing, a first (meth)acrylic polymer and a first (meth)acrylic monomer; and
a surface layer comprising at least 90 wt. %, relative to total surface layer weight, of a cured second composition comprising, prior to curing, a second (meth)acrylic polymer, a second (meth)acrylic monomer, and
0.5 wt. % of zirconium dioxide nanoparticles, relative to a total surface layer weight, wherein no gradient in zirconium dioxide nanoparticles content and no continuous bulk containing the zirconium dioxide nanoparticles is present between the first and surface layers,
wherein the first layer is free of the zirconium dioxide nanoparticles, and
wherein the material has a flexural strength in a range of 85 to 87 MPa, a translucency parameter in a range of 12 to 13, and a surface roughness in a range of 0.13 to 0.15 μm.

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Gad Mohammed Moustafa Ahmed
• Abualsaud Reem
• Rahoma Ahmed Mohamed
• Fouda Shaimaa Mohamed Said
• Al-Thobity Ahmad M

Classifications

• A61K6/70 Primary

  comprising inorganic additives · CPC title

• A61K6/17

  Particle size · CPC title

• A61K6/891

  Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61C8/0013

  with a surface layer, coating · CPC title

• A61C8/0095

  Total denture implant · CPC title