Noninvasive glucometer and blood glucose detection method

Patent metadata

Field	Value
Publication number	US-11759129-B2
Application number	US-201916978122-A
Country	US
Kind code	B2
Filing date	Aug 21, 2019
Priority date	Jul 31, 2019
Publication date	Sep 19, 2023
Grant date	Sep 19, 2023

Abstract

A noninvasive glucometer and a blood glucose detection method are provided. The noninvasive glucometer includes a light source, a spectrometer and detecting space into which an object to be detected intervenes; the detecting space is connected with the light source and the spectrometer respectively, so that a spectrum emitted by the light source can generate incident light entering the spectrometer after passing through the object to be detected. The spectrometer includes: an optical modulation layer configured to perform light modulation on the incident light to obtain a modulated spectrum; a photoelectric detection layer located below the optical modulation layer, and configured to receive the modulated spectrum and provide differential responses with respect to the modulated spectrum; and a signal processing circuit layer located below the photoelectric detection layer and configured to reconstruct the differential responses to obtain an original spectrum.

First claim

The invention claimed is:

1. A noninvasive glucometer, comprising a light source and a spectrometer; wherein, a spectrum emitted by the light source generates incident light entering the spectrometer after passing through an object to be detected;
the spectrometer comprises:
an optical modulation layer, the optical modulation layer comprising a base plate and one or more modulation units, the one or more modulation units being located on the base plate, each of the one or more modulation units being provided with several modulation holes, each of the modulation holes being configured to perform light modulation on the incident light to obtain a modulated spectrum, and the modulated spectrum being a broadband spectrum;
a photoelectric detection layer located below the optical modulation layer, and configured to receive the modulated spectrum and provide a differential response with respect to the modulated spectrum; and
a signal processing circuit layer located below the photoelectric detection layer and configured to reconstruct an original spectrum utilizing the differential response,
wherein the optical modulation layer is made of silicon, germanium, silicon germanium materials, silicon compounds, germanium compounds, or III-V group materials.

2. The noninvasive glucometer of claim 1 , wherein the base plate is provided on the photoelectric detection layer, and the respective modulation holes in each of the modulation units are arranged into a two-dimensional graphic structure.

3. The noninvasive glucometer of claim 2 , wherein, the two-dimensional graphic structure comprises that:
all the modulation holes inside respective two-dimensional graphic structures have the same specific cross-sectional shapes and the respective modulation holes are arranged in an array in an order that sizes of structural parameters are gradually varied; and/or
the respective modulation holes inside the respective two-dimensional graphic structures respectively have a specific cross-sectional shape, and the respective modulation holes are combined and arranged according to the specific cross-sectional shape.

4. The noninvasive glucometer of claim 3 , wherein, an arrangement order is being arranged row by row or column by column according to a preset period order when the respective modulation holes are arranged and combined according to the specific cross-sectional shape.

5. The noninvasive glucometer of claim 2 , wherein a bottom of at least one of the modulation holes penetrates the base plate.

6. The noninvasive glucometer of claim 1 , wherein the photoelectric detection layer comprises one or more detection units, the one or more detection units are correspondingly provided below each modulation unit of the optical modulation layer, and the one or more detection units are electrically connected through the signal processing circuit layer.

7. The noninvasive glucometer of claim 1 , wherein, the spectrometer further comprises:
a light-transmitting medium layer located between the optical modulation layer and the photoelectric detection layer.

8. The noninvasive glucometer of claim 1 , wherein the light source and the spectrometer are respectively provided on both sides of the object to be detected; or
the light source and the spectrometer are arranged on one side of the object to be detected.

9. The noninvasive glucometer of claim 1 , further comprising:
a data processing module connected to the signal processing circuit layer and configured to perform analysis and calculation on the original spectrum to obtain blood glucose parameters; and
a data display module connected to the data processing module and configured to display the blood glucose parameters.

10. A blood glucose detection method based on the glucometer of claim 1 , comprising:
moving the object to be detected into a detecting space connected with the light source and the spectrometer, so that the spectrum emitted by the light source passes through the object to be detected and the incident light entering the spectrometer is generated;
performing the light modulation on the incident light through the modulation holes to obtain the modulated spectrum, wherein the modulated spectrum is a broadband spectrum;
receiving the modulated spectrum and providing the differential response with respect to the modulated spectrum; and
reconstructing the original spectrum utilizing the differential response.

11. The noninvasive glucometer of claim 2 , wherein, the spectrometer further comprises:
a light-transmitting medium layer located between the optical modulation layer and the photoelectric detection layer.

12. The noninvasive glucometer of claim 3 , wherein, the spectrometer further comprises:
a light-transmitting medium layer located between the optical modulation layer and the photoelectric detection layer.

13. The noninvasive glucometer of claim 4 , wherein, the spectrometer further comprises:
a light-transmitting medium layer located between the optical modulation layer and the photoelectric detection layer.

14. The noninvasive glucometer of claim 5 , wherein, the spectrometer further comprises:
a light-transmitting medium layer located between the optical modulation layer and the photoelectric detection layer.

15. The noninvasive glucometer of claim 6 , wherein, the spectrometer further comprises:
a light-transmitting medium layer located between the optical modulation layer and the photoelectric detection layer.

16. The noninvasive glucometer of claim 2 , wherein the light source and the spectrometer are respectively provided on both sides of the object to be detected; or
the light source and the spectrometer are arranged on one side of the object to be detected.

17. The noninvasive glucometer of claim 3 , wherein the light source and the spectrometer are respectively provided on both sides of the object to be detected; or
the light source and the spectrometer are arranged on one side of the object to be detected.

18. The noninvasive glucometer of claim 4 , wherein the light source and the spectrometer are respectively provided on both sides of the object to be detected; or
the light source and the spectrometer are arranged on one side of the object to be detected.

Assignees

• Univ Tsinghua

Inventors

• Cui Kaiyu
• Cai Xusheng
• Zhu Hongbo
• Huang Yidong
• Feng Xue
• Liu Fang
• Zhang Wei

Classifications

• A61B5/0075 Primary

  by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence) · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/1455 Primary

  using optical sensors, e.g. spectral photometrical oximeters · CPC title

• A61B5/7264

  Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems · CPC title

• A61B5/726

  using Wavelet transforms · CPC title