Antioxidant contact lens

Patent metadata

Field	Value
Publication number	US-11754753-B2
Application number	US-202117228748-A
Country	US
Kind code	B2
Filing date	Apr 13, 2021
Priority date	Apr 27, 2020
Publication date	Sep 12, 2023
Grant date	Sep 12, 2023

Abstract

A contact lens having antioxidant properties is described as well as methods of manufacturing the same. The contact lens can be present in a sealed contact lens package. The seal contact lens package can include at least a) a plastic base member having a cavity; b) a contact lens packaging solution in the cavity; c) a sterile, unworn contact lens immersed in the contact lens packaging solution in the cavity; and d) a cover that forms a liquid-tight seal with the plastic base member. As an example, the unworn contact lens is a silicone hydrogel contact lens having present therein vitamin E. The vitamin E is non-releasable from the unworn contact lens and the contact lens packaging solution has less than 1 ppm of vitamin E present. The vitamin E is trapped, embedded, absorbed, or non-covalently attached in the unworn contact lens.

First claim

What is claimed is:

1. An unworn antioxidant contact lens immersed in a packaging solution and sterilely sealed in a package, said contact lens comprising a silicone hydrogel and amount of vitamin E embedded within the silicone hydrogel effective to provide at least a 50% reduction in lipid peroxidation relative to a control contact lens lacking the vitamin E when measured in a TBARS assay, wherein the antioxidant contact lens is free of a bioactive agent having a release profile attenuated by the vitamin E.

2. An unworn antioxidant contact lens immersed in a packaging solution and sterilely sealed in a package, said contact lens comprising a silicone hydrogel and amount of vitamin E embedded within the silicone hydrogel effective to provide at least a 50% reduction in lipid peroxidation relative to a control contact lens lacking the vitamin E when measured in a TBARS assay, wherein the antioxidant contact lens has (a) an ophthalmically-acceptable surface wettability in the absence of a post curing surface treatment and (b) an advancing contact angle that is no more than 10° greater than the control lens.

3. An unworn antioxidant contact lens immersed in a packaging solution and sterilely sealed in a package, said contact lens comprising a silicone hydrogel and 10 μg to 1000 μg of vitamin E embedded in the silicone hydrogel, wherein the antioxidant contact lens (a) has a heat stability that is no greater than a control contact lens lacking the vitamin E and (b) is free of a bioactive agent having a release profile attenuated by the vitamin E.

4. The unworn antioxidant contact lens of claim 1 , wherein the amount of vitamin E is 10 μg to 1000 μg per 25 mg of the antioxidant contact lens when fully hydrated.

5. The unworn antioxidant contact lens of claim 1 having a % equilibrium water content (% EWC) that is no less than 5% that of the control lens.

6. The unworn antioxidant contact lens of claim 1 having between 40% to 60% EWC.

7. The unworn antioxidant contact lens of claim 1 having a lens diameter within ±0.2 mm that of the control lens.

8. The unworn antioxidant contact lens of claim 1 having an advancing contact angle that is no more than 5° greater than the control lens.

9. The unworn antioxidant contact lens of claim 1 wherein the reduction in lipid peroxidation is at least 80%.

10. The unworn antioxidant contact lens of claim 1 , wherein the amount of vitamin E is effective to reduce generation of reactive oxygen species (ROS) from human corneal epithelial cells (HCECs) contacted in vitro with H 2 O 2 relative to the control contact lens when measured in an HCEC viability assay.

Assignees

• Coopervision Int Ltd

Inventors

• Maltseva Inna
• Keir Nancy J
• Luk Andrew
• Rogers Victoria

Classifications

• B29D11/00067

  Hydrating contact lenses · CPC title

• B29D11/00096

  for delivering compositions, e.g. drugs to the eye · CPC title

• G02B1/043 Primary

  Contact lenses · CPC title

• G02C7/04 Primary

  Contact lenses for the eyes (disinfection or sterilisation of contact lenses A61L12/00) · CPC title

• A45C11/005

  Contact lens cases (A45C11/046 takes precedence) · CPC title