Medical device for stimulating and sensing bioactivity

Patent metadata

Field	Value
Publication number	US-11754550-B2
Application number	US-201816045987-A
Country	US
Kind code	B2
Filing date	Jul 26, 2018
Priority date	Jul 26, 2018
Publication date	Sep 12, 2023
Grant date	Sep 12, 2023

Abstract

In an approach, a biomedical device comprises at least one electrode, wherein the at least one electrode is coupled with a computer chip; at least two chemical sensors, wherein the at least two chemical sensors are coupled with the computer chip; the computer chip, wherein the computer chip comprises: a semiconductor substrate, and a processor; a microfluidic structure, wherein the microfluidic structure is an inert elastomeric polymer; a power supply device coupled to the computer chip; and an antenna configured to send data collected onto the computer chip to a remote server. In an approach, a processor stimulating a cell sample. A processor senses the presence of at least two types of biomolecules released by the cell sample. A processor records data collected by the at least two chemical sensors. A processor sends the recorded data to a remote server.

First claim

What is claimed is:

1. An apparatus for a biomedical device, the apparatus comprising:
a computer chip, wherein the computer chip comprises:
a semiconductor substrate, and
a processor;

at least one electrode, wherein the at least one electrode is coupled with a top side of the computer chip;
at least two chemical sensors, wherein the at least two chemical sensors are coupled with the top side of the computer chip;
a microfluidic structure, wherein the microfluidic structure is an inert elastomeric polymer, and wherein the microfluidic structure encases all but the top side of the computer chip;
a power supply device coupled to the computer chip; and
an antenna configured to send data collected onto the computer chip to a remote server.

2. The apparatus of claim 1 , wherein the at least one electrode is configured to stimulate a cell sample.

3. The apparatus of claim 1 , wherein the at least one electrode is configured to sense a voltage differential across a cell sample.

4. The apparatus of claim 1 , wherein the at least one electrode is configured to stimulate a cell sample and sense a voltage differential across the cell sample.

5. The apparatus of claim 1 , wherein a first chemical sensor of the at least two chemical sensors is an amperometric sensor covered in a first bioenzyme and a second chemical sensor of the at least two chemical sensors is an amperometric sensor covered in a second bioenzyme.

6. The apparatus of claim 1 , wherein a first chemical sensor of the at least two chemical sensors is a resistivity sensor created in the presence of a first biomolecule and a second chemical sensor of the at least two chemical sensors is a resistivity sensor created in the presence of a second biomolecule.

7. The apparatus of claim 1 , wherein a first chemical sensor of the at least two chemical sensors is an amperometric sensor covered in a first bioenzyme and a second chemical sensor of the at least two chemical sensors is a resistivity sensor created in the presence of a first biomolecule.

8. The apparatus in claim 1 , wherein the computer chip is operatively coupled to the at least two chemical sensors and the at least one electrode.

9. The apparatus of claim 1 , wherein the microfluidic structure comprises at least one channel to facilitate the release of biomolecules stored within the microfluidic structure used to stimulate a cell sample.

Assignees

• IBM

Inventors

• Deligianni Harikilia
• Doris Bruce B
• Holmes Steven J
• Kinser Emily R
• Lin Qinghuang

Classifications

• G01N33/48735 Primary

  Investigating suspensions of cells, e.g. measuring microbe concentration (by chemical means C12Q1/04; colony counters C12M1/34; concentration of particle suspensions in general G01N15/06) · CPC title

• G01N33/48785

  Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply · CPC title

• G01N33/48792

  Data management, e.g. communication with processing unit (for in vivo diagnostics A61B5/0002; transmission systems for measured values G08C) · CPC title

• B01L3/502715

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title

• B01L2300/023

  Sending and receiving of information, e.g. using Bluetooth® · CPC title