Methods and systems for stimulating nerve signals

Patent metadata

Field	Value
Publication number	US-11752339-B2
Application number	US-201715608872-A
Country	US
Kind code	B2
Filing date	May 30, 2017
Priority date	May 27, 2016
Publication date	Sep 12, 2023
Grant date	Sep 12, 2023

Abstract

Systems and methods of generating and applying a synthetic neuromodulatory signal are described. A subject may be put under a particular condition that causes an effect in the subject. While the subject is under the condition, a recording of neurogram signals derived from the condition can be made from the subject. For example, neuronal signals traveling on the vagus nerve of the subject may be monitored and recorded. The neurogram may then be used to create a synthetic neuromodulatory signal that can be administered to a user. When the synthetic neuromodulatory signal is administered to the user, the user may experience the same effect as the subject that had been placed in the condition, even though the user was never put under the same condition.

First claim

What is claimed is:

1. A system for applying a neuromodulatory signal to an intended target, comprising:
a neuromodulatory signal generator system configured to generate a plurality of synthetic neuromodulatory signals, wherein each synthetic neuromodulatory signal represents at least one processed measured nerve tissue signal as a sequence of one or more states represented by one or more state parameters; and
an electronic device is configured to communicate with the neuromodulatory signal generator system, wherein the electronic device comprises
a user interface configured to receive a selection of at least one desired effect from the intended target;
a library configured to cooperate with the user interface, where the library is configured to store a set of state parameters for generating synthetic neuromodulatory signals, which are derived from measured nerve tissue signals generated by neurons in a subject, for the at least one desired effect selected without application of a drug to the intended target in a safe range of parameters for that intended target, where two or more potential safe ranges of parameters are stored in the library based on different possible intended targets;
a communication module configured to receive the selection of the at least one desired effect from the user interface and connect to the neuromodulatory signal generation system to retrieve a first synthetic neuromodulatory signal associated with the selected desired effect;
where the user interface is configured to interact with a neuromodulatory signal generator in the neuromodulatory signal generator system, where the neuromodulatory signal generator is configured to generate the synthetic neuromodulatory signals, where the synthetic neuromodulatory signals are configured to emulate a stimulation of nerves as an alternative to drug-based treatments; and
wherein application of the retrieved synthetic neuromodulatory signal to the intended target is configured to cause the intended target to experience the desired effect without application of the drug to the intended target.

2. The system of claim 1 , where the library is configured to contain a set of two or more synthetic neuromodulatory signals, each set of synthetic neuromodulatory signals associated with a specific desired effect and its one or multiple states along with control data that contains information about how to apply the synthetic neuromodulatory signals to achieve the specific desired effect.

3. The system of claim 1 ,
wherein the neuromodulatory signal generator system comprises a storage module, where the storage module is configured to receive and store a plurality of the measured nerve tissue signals produced by neurons in the subject subjected to a condition in response to application of the condition to the subject to cause the subject to experience the desired effect without application of the drug to the subject, and
wherein the neuromodulatory signal generator system comprises a state machine generator module configured to communicate with the storage module to receive at least one peripheral nerve tissue signal from the measured nerve tissue signals produced by neurons in the subject, where the state machine generator module is configured to cooperate with the neuromodulatory signal generator to create the synthetic neuromodulatory signal that emulate the stored measured nerve tissue signals produced by neurons in the subject to evoke responses of the particular drug being replaced in the intended target, where the state machine generator module is configured to create the synthetic neuromodulatory signal by representing the measured nerve tissue signals produced by neurons in the subject as a sequence of one or more states, wherein each state is represented by one or more state parameters that are converted to form the synthetic neuromodulatory signal.

4. The system of claim 1 , where the user interface is configured to cooperate with one or more access control mechanisms to give different types of intended targets different levels of access, where the access control mechanisms are configured to restrict access to only those synthetic neuromodulatory signals that have been approved for use for that type of intended target.

5. The system of claim 1 , wherein the neuromodulatory signal generator system comprises stored operational parameters selected from the group consisting of: a) identification parameters identifying the needs or wants of the intended target; b) scheduled delivery time parameters of the first synthetic neuromodulatory signal; c) frequency of application parameters of the first synthetic neuromodulatory signal; d) parameters indicating a duration of application of the first synthetic neuromodulatory signal; and e) parameters indicating the strength of the first synthetic neuromodulatory signal, where the intended target is at least one of i) a human subject and ii) another animal subject in order to create the set of state parameters for generating synthetic neuromodulatory signals within the safe range for that human subject or that other animal subject.

6. The system of claim 1 , where the measured nerve tissue signals generated by the neurons in the subject are recorded in response to stimulation of nerve tissue being applied from one or more stimulation sources consisting of at least one of i) a speaker, ii) headphones, iii) an ear bud, iv) a light emitting diode or other light-emitting device, v) a mechanical vibrator, vi) an RF transducer, and vii) a mechanical device; rather than, electrical stimulation through electrodes.

7. A method of retrieving a synthetic neuromodulatory signal to be administered to an intended target, comprising:
receiving a selection of a desired effect from a user interface of an electronic device;
downloading the synthetic neuromodulatory signal associated with the desired effect to the electronic device in response to the selection, where the synthetic neuromodulatory signal is configured to stimulate nerves as an alternative to drug-based treatments, where application of the synthetic neuromodulatory signal to the intended target causes the intended target to experience the desired effect without application of a drug to the intended target;
receiving an input of operational parameters from the user interface relating to application of the downloaded synthetic neuromodulatory signal in a safe range of operational parameters for that intended target, where two or more potential safe ranges of operational parameters are stored based on different possible intended targets, where the synthetic neuromodulatory signal to be applied was derived from measured nerve tissue signals generated by neurons in a subject, for the desired effect selected without application of the drug to the intended target in the safe range of operational parameters for that intended target, and wherein the synthetic neuromodulatory signal is applied to the intended target to cause the intended target to experience the desired effect without application of the drug to the intended target, and
applying a representation of the synthetic neuromodulatory signal to the intended target of the subject according to the received operational parameters with a neuromodulatory signal generator.

8. The method of claim 7 , further comprising applying the representation of the synthetic neuromodulatory signal to the intended target according to the received operational parameters in the safe range to cause the intended target to experience the desired effect.

9. The method of claim 7 , wherein retrieving the synthetic neuromodulatory signal further comprises receiving at least one processed measured peripheral nerve tissue signal and creating the synthetic neuromodulatory sig

Assignees

• Stanford Res Inst Int

Inventors

• Connolly Christopher
• Lincoln Patrick
• Yadav Maneesh
• Cornwell John
• Ramamurthy Bhaskar

Classifications

• A61N1/3605 Primary

  Implantable neurostimulators for stimulating central or peripheral nerve system · CPC title

• A61B5/4029

  for evaluating the peripheral nervous systems (using bioelectric or biomagnetic signals A61B5/24) · CPC title

• A61B5/4836

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61N1/36053

  adapted for vagal stimulation (A61N1/36114 takes precedence) · CPC title

• A61B2503/40

  Animals · CPC title