Medical treatment system and methods using a plurality of fluid lines

Patent metadata

Field	Value
Publication number	US-11752248-B2
Application number	US-201916247204-A
Country	US
Kind code	B2
Filing date	Jan 14, 2019
Priority date	Jan 23, 2008
Publication date	Sep 12, 2023
Grant date	Sep 12, 2023

Abstract

Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of the diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater element. Improvements are also disclosed in an application of negative pressure during a drain phase in peritoneal dialysis therapy, and to control an amount of intraperitoneal fluid accumulation during the therapy. Improvements in efficiency are also disclosed in movement of fluid into and out of a two-pump cassette and a heater bag of the peritoneal dialysis cycler, and in synchronization of operation of two or more pumps in the peritoneal dialysis cycler or other fluid handling devices using a multi-pump arrangement.

First claim

The invention claimed is:

1. A system to withdraw fluid from a cavity of a patient, the system comprising:
a pump configured to provide at least a first negative pressure and at least a first positive pressure to a patient line fluidly connected to the cavity;
a controller configured to measure and control the first negative pressure and the first positive pressure provided by the pump;
the controller also configured to measure at least a first fluid flow rate through from the patient line;
wherein the controller is arranged to control the pump to provide the first negative pressure to the patient line, measure the first fluid flow rate through the patient line, and control the pump to provide the first positive pressure to the patient line if the first fluid flow rate is less than a pre-determined value;
and wherein the controller is arranged to control the pump to provide a second negative pressure to the patient line if a second fluid flow rate through the patient line measured upon application of the first positive pressure is greater than a pre-determined amount.

2. The system of claim 1 , wherein the controller is configured to control the pump to apply the first negative pressure for a predetermined period of time.

3. The system of claim 2 , wherein the first negative pressure is set to a minimum negative pressure of the at least the first negative pressure.

4. The system of claim 1 , wherein the controller is configured to stop adjustment of a pumping pressure provided to the patient line if a flow rate through the patient line is less than a pre-determined threshold flow rate for more than a pre-determined period of time.

5. The system of claim 1 , wherein the controller is configured to control the pump to terminate a drain cycle if a cumulative volume of the fluid withdrawn is equal to or greater than a target volume.

6. The system of claim 1 , wherein the pump is a pneumatically actuated diaphragm pump comprising a pumping chamber fluidly connected to the patient line, an actuation chamber connected to a pressure distribution manifold and a flexible diaphragm between the actuation chamber and the pumping chamber;
wherein the controller measures an actuation chamber pressure from a pressure sensor in communication with the actuation chamber of the pump, and a reference chamber pressure from a pressure sensor in communication with a reference chamber in valved communication with the actuation chamber of the pump; the controller configured to control a valve in the pressure distribution manifold to deliver the at least the first negative pressure to the actuation chamber; the controller also configured to determine the measured first fluid flow rate based on the actuation chamber pressure and the reference chamber pressure.

7. The system of claim 1 , wherein the pre-determined value is in a range of approximately 35 to 75 ml/min.

8. The system of claim 1 , wherein the controller is arranged to control the pump to provide the first negative pressure at −6.5 kPa.

9. The system of claim 1 , further comprising a user interface and wherein the controller signals an alert if the measured first fluid flow rate is less than the pre-determined value.

10. The system of claim 1 , further comprising a user interface and wherein the controller signals an occlusion alert if the measured second fluid flow rate upon application of the first positive pressure is less than the pre-determined amount.

11. The system of claim 1 , wherein the controller is arranged to measure a third fluid flow rate after a first period of time after the first fluid flow rate is measured and signals an alert if the third fluid flow rate has been less than the pre-determined value for a second period of time.

12. The system of claim 1 , wherein the second negative pressure is equal to the first negative pressure.

13. The system of claim 1 , wherein the pump is a pneumatically actuated diaphragm pump comprising a pumping chamber fluidly connected to the patient line, an actuation chamber connected to a pressure distribution manifold and a flexible diaphragm between the actuation chamber and the pumping chamber;
wherein the controller measures an actuation chamber pressure from a pressure sensor in communication with the actuation chamber of the pump; the controller configured to control a valve in the pressure distribution manifold to provide the first negative pressure including a time-varying negative pressure to the actuation chamber; the controller also configured to determine the measured first fluid flow rate based on the time-varying actuation chamber pressure.

14. A system to withdraw fluid from a cavity of a patient, the system comprising:
a pump configured to provide at least a first negative pressure and at least a first positive pressure to a patient line fluidly connected to the cavity;
a controller configured to measure and control the first negative pressure and the first positive pressure provided by the pump;
the controller also configured to measure a first fluid flow rate through the patient line;
wherein the controller is configured to control the pump to provide the first negative pressure to the patient line, measure the first fluid flow rate, and control the pump to provide a second negative pressure to the patient line when the measured first fluid flow rate is greater than a pre-determined value.

15. The system of claim 14 , further comprising a user interface, wherein the controller signals an alert when the measured first fluid flow rate is less than the pre-determined value.

16. The system of claim 14 , wherein the controller controls is configured to control the pump to provide the second negative pressure to the patient line when the measured first fluid flow rate is greater than the pre-determined value for a first pre-determined period of time.

17. The system of claim 14 , further comprising a user interface, wherein the controller signals an alert when the measured first fluid flow rate is less than the pre-determined value for a first pre-determined period of time.

Assignees

• Deka Products Lp

Inventors

• Beavers David A
• Norris Michael G
• Kerwin John M
• Coll Andrew S
• Girouard Paul G
• Bryant Jr Robert J
• Spencer Geoffrey P
• Rushlow Joseph P
• Scarpaci Jacob W

Classifications

• A61M1/282 Primary

  Operational modes · CPC title

• A61M1/166

  Heating (for sterilisation A61M1/1686) · CPC title

• A61M1/28

  Peritoneal dialysis {; Other peritoneal treatment, e.g. oxygenation} · CPC title

• A61M1/288

  Priming (priming in extracorporeal blood circuits A61M1/3643) · CPC title

• A61M1/3656

  Monitoring patency or flow at connection sites; Detecting disconnections · CPC title