Antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and a diol, and cosmetic composition containing same

Patent metadata

Field	Value
Publication number	US-11752079-B2
Application number	US-201816626051-A
Country	US
Kind code	B2
Filing date	Jun 27, 2018
Priority date	Jun 30, 2017
Publication date	Sep 12, 2023
Grant date	Sep 12, 2023

Abstract

The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxy-phenyl)butan-2-one and a diol compound chosen from 1,3-propanediol, 1,2-octane-diol and 1,2-decanediol, and also to a cosmetic composition containing such a mixture. Use in caring for, making up and cleansing keratin materials.

First claim

The invention claimed is:

1. An antimicrobial mixture comprising 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and 1,3-propanediol, wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and 1,3-propanediol are present in the mixture in an amount such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/1,3-propanediol weight ratio ranges from 0.02 to 0.15 and wherein the antimicrobial mixture exhibits synergistic inhibitory activity.

2. The antimicrobial mixture according to claim 1 , wherein said weight ratio ranges from 0.02 to 0.07.

3. A composition comprising, in a physiologically acceptable medium, an antimicrobial mixture according to claim 1 .

4. The composition according to claim 3 , which comprises at least one additional ingredient chosen from water, oils, polyols containing from 2 to 10 carbon atoms, gelling agents, surfactants, film-forming polymers, colorants, fragrances, fillers, UV-screening agents, plant extracts, cosmetic and dermatological active agents, and salts.

5. The composition according to claim 3 , wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present in a content ranging from 0.01% to 5% by weight relative to the total weight of the composition.

6. A method for the conservation of a composition comprising a physiologically acceptable medium which comprises including an antimicrobial mixture according to claim 1 in said composition.

7. The composition according to claim 3 , wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present in a content ranging from 0.01% to 5% by weight relative to the total weight of the composition and the weight ratio of the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/1,3-propanediol ranges from 0.02 to 0.07.

8. The antimicrobial mixture according to claim 1 , which exhibits synergistic inhibitory activity against moulds.

9. The antimicrobial mixture according to claim 1 , which exhibits synergistic inhibitory activity against Aspergillus niger.

10. A composition comprising, in a physiologically acceptable medium, an antimicrobial mixture according to claim 9 .

11. The composition according to claim 10 , which comprises at least one additional ingredient chosen from water, oils, polyols containing from 2 to 10 carbon atoms, gelling agents, surfactants, film-forming polymers, colorants, fragrances, fillers, UV-screening agents, plant extracts, cosmetic and dermatological active agents, and salts.

12. The composition according to claim 10 , wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present in a content ranging from 0.01% to 5% by weight relative to the total weight of the composition.

13. A composition comprising, in a physiologically acceptable medium, an antimicrobial mixture according to claim 8 .

14. The composition according to claim 13 , which comprises at least one additional ingredient chosen from water, oils, polyols containing from 2 to 10 carbon atoms, gelling agents, surfactants, film-forming polymers, colorants, fragrances, fillers, UV-screening agents, plant extracts, cosmetic and dermatological active agents, and salts.

15. The composition according to claim 13 , wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present in a content ranging from 0.01% to 5% by weight relative to the total weight of the composition.

Assignees

• Oreal

Inventors

• Menard-Szczebara Florence
• Cupferman Sylvie
• Galvan Julien
• CHEVALIER VéRONIQUE

Classifications

• A01N35/02 Primary

  containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals · CPC title

• A61K8/35 Primary

  Ketones, e.g. benzophenone · CPC title

• A61K8/062

  Oil-in-water emulsions · CPC title

• A61K8/345

  containing more than one hydroxy group · CPC title

• A61K2800/524

  Preservatives · CPC title