Method and system for preparing a solution

Patent metadata

Field	Value
Publication number	US-11747240-B2
Application number	US-201916722644-A
Country	US
Kind code	B2
Filing date	Dec 20, 2019
Priority date	Dec 20, 2018
Publication date	Sep 5, 2023
Grant date	Sep 5, 2023

Abstract

The present disclosure relates to a capsule for preparing a solution for use with a measuring device for determining a measurand that depends on a concentration of at least one analyte in a sample. The capsule includes a wall completely enclosing an interior, at least one substance accommodated within the interior, and at least one stirring body. The present disclosure also relates to a system, which includes at least one capsule and a liquid container closed in a liquid-tight manner, which contains a predetermined volume of a liquid containing a solvent. In addition, the wall of the capsule is formed from a material which dissolves at least partially in the solvent.

First claim

The invention claimed is:

1. A capsule for preparing a solution for use with a measuring device for determining a measurand that depends on a concentration of at least one analyte in a sample, including:
a wall completely enclosing an interior;
at least one substance accommodated within the interior; and
at least one stirring body positioned within in the interior;
wherein the substance is present in the interior of the capsule as a solid or bound to a solid phase.

2. The capsule of claim 1 , wherein the stirring body has a magnet.

3. The capsule of claim 1 , wherein the stirring body is surrounded by the wall or connected to the wall or at least partially embedded in the wall.

4. The capsule of claim 1 , wherein the wall is formed from a material which is at least partially soluble in a solvent.

5. The capsule of claim 1 , wherein the substance comprises a predetermined quantity of the analyte or of a substance which can be converted by chemical reaction to the analyte.

6. The capsule of claim 1 , wherein the substance comprises a predetermined quantity of a first reactant which is selected such that it undergoes with at least one second reactant a chemical reaction in which the analyte forms as a reaction product.

7. A system for preparing a solution for use with a measuring device for determining a measurand that depends on a concentration of at least one analyte in a sample, including:
at least one capsule including:
a wall completely enclosing an interior;
at least one substance accommodated within the interior; and
at least one stirring body positioned within the interior; and

a liquid container which contains a predetermined volume of a liquid containing a solvent;
wherein the wall of the capsule is formed from a material which dissolves at least partially in the solvent
wherein the substance is present in the interior of the capsule as a solid or bound to a solid phase.

8. The system of claim 7 , wherein the stirring body includes a magnet, and wherein the system further comprises a magnetic stirrer configured to generate a magnetic field serving to drive the stirring body.

9. The system of claim 7 , wherein the solution is a standard solution for calibrating, verifying or adjusting the measuring device.

10. The system of claim 9 , wherein the substance forms a first component of the standard solution, and wherein the liquid forms a second component of the standard solution.

11. The system of claim 9 , wherein the substance comprises a predetermined quantity of the analyte or of a first reactant which, upon mixing and/or dissolving the substance in the liquid, undergoes a chemical reaction which involves at least one second reactant contained in the liquid and in which the analyte forms as a reaction product.

12. The system of claim 7 , wherein the at least one first capsule is enclosed in an outer packaging in a gas-tight and liquid-tight manner.

13. The system of claim 7 , wherein the at least one capsule is accommodated in a blister packaging which has a flexible rear wall on which the at least one capsule rests and a plastic film molding which is connected to the flexible rear wall in such a way that the plastic film molding and the rear wall form a closed chamber in which the at least one capsule is arranged.

14. A method for preparing a solution for use with a measuring device for determining a measurand that depends on a concentration of at least one analyte in a sample, including:
adding at least one capsule to a volume of a liquid comprising a solvent already present in a liquid container, wherein the capsule has a wall completely surrounding an interior and at least one substance accommodated within the interior, and at least one stirring body positioned within the interior;
wherein the wall of the capsule at least partially dissolves in the liquid and the substance accommodated in the interior escapes into the liquid; and
mixing the substance with the liquid and/or dissolving the substance in the liquid;
wherein the substance is present in the interior of the capsule as a solid or bound to a solid phase.

15. The method of claim 14 , wherein the liquid container is initially closed and wherein the method comprises the further step of:
opening the liquid container and adding the capsule to the volume of the liquid already provided in the liquid container, wherein the substance escaping from the capsule is mixed with the liquid or dissolved in the liquid in the liquid container.

16. The method of claim 14 , wherein the stirring body includes a magnet, and wherein the method further comprises the step of bringing the liquid container close to or in contact with a magnetic stirrer which is configured to generate a magnetic field which serves to drive the stirring body, in such a way that the magnetic field causes the magnet of the capsule to move after the capsule has been added to the liquid.

17. The method of claim 14 , wherein the solution is a standard solution for calibrating, verifying or adjusting the measuring device, and wherein the substance forms a first component of the standard solution, and wherein the liquid forms a second component of the standard solution.

18. The method of claim 14 , wherein the wall of the capsule is formed from a material which does not influence the determination of the measurand by means of the measuring device.

19. The method of claim 14 , wherein the liquid contains at least one stabilizer for inhibiting chemical or photochemical degradation reactions of the analyte in the prepared solution.

20. The method of claim 14 , including:
detecting by means of the measuring device at least one measured value of the measurand in at least a portion of the standard solution; and
calibrating, verifying or adjusting the measuring device using the at least one measured value.

Assignees

• Endress Hauser Conducta Gmbh Co Kg

Inventors

• Gerlinger Anja
• Kathe Ulrich
• Schweitzer Daniel

Classifications

• G01N1/28 Primary

  Preparing specimens for investigation {including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q}(mounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 {; laboratory gas handling apparatus B01L5/00}) · CPC title

• G01N2001/2893

  Preparing calibration standards · CPC title

• B01F21/02 Primary

  Methods · CPC title

• G01N1/38

  Diluting, dispersing or mixing samples · CPC title

• B01F2101/23

  Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials · CPC title