Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system

Patent metadata

Field	Value
Publication number	US-11746319-B2
Application number	US-202016889632-A
Country	US
Kind code	B2
Filing date	Jun 1, 2020
Priority date	Oct 8, 2010
Publication date	Sep 5, 2023
Grant date	Sep 5, 2023

Abstract

Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.

First claim

What is claimed is:

1. A non-transitory processor-readable storage medium storing executable instructions which, when executed by a processor, perform a method of customizing a protocol for use with a cell expansion system, the method comprising:
receiving a first selection, in a user interface associated with the cell expansion system, to customize a first protocol for expanding a plurality of cells in a bioreactor of the cell expansion system, wherein the user interface is operable to display data and receive an input;
in response to receiving the first selection, providing, through the user interface, a diagram view of the cell expansion system for customizing the first protocol, comprising:
providing a first setting for the first protocol as a first graphical user interface (GUI) element for selection;
receiving, through the user interface, a second selection of the first GUI element;
receiving, through the user interface, a first value for the first GUI element;
receiving a third selection to execute the first protocol; and
executing the first protocol using the first value for the first setting to expand the plurality of the cells.

2. The non-transitory processor-readable storage medium as defined in claim 1 , the method further comprising:
providing, through the user interface, one or more types of processes to add;
receiving, through the user interface, a fourth selection of a first process; and
in response to receiving the fourth selection, associating the diagram view with the first process.

3. The non-transitory processor-readable storage medium as defined in claim 2 , wherein the one or more types of processes to add comprises: wash out lines, wash out lines through membrane, wash rapidly, harvest cells, add bolus, and/or custom.

4. The non-transitory processor-readable storage medium as defined in claim 1 , the method further comprising:
determining the first setting is associated with a numeric value; and
in response to determining the first setting is associated with the numeric value, providing a data entry pad in the diagram view to receive the first value.

5. The non-transitory processor-readable storage medium as defined in claim 4 , the method further comprising:
receiving, through the data entry pad, the first value for the first setting; and
storing the first value for the first setting.

6. The non-transitory processor-readable storage medium as defined in claim 1 , the method further comprising:
determining the first setting is associated with a menu of selection options; and
in response to determining the first setting is associated with the menu of selection options, providing the menu of selection options in the diagram view.

7. The non-transitory processor-readable storage medium as defined in claim 1 , wherein the user interface comprises a touch screen.

8. The non-transitory processor-readable storage medium as defined in claim 7 , wherein the touch screen comprises an input device that can receive one or more touch events.

9. The non-transitory processor-readable storage medium as defined in claim 8 , wherein the receiving the first selection comprises:
receiving a touch event on the touch screen, wherein the touch screen comprises a display area;
determining a location of the touch event;
mapping the location of the touch event to the first GUI element; and
determining the first GUI element is associated with the first setting.

10. The non-transitory processor-readable storage medium as defined in claim 1 , wherein the first setting comprises: intracapillary inlet, intracapillary inlet rate, intracapillary circulation rate, extracapillary inlet, extracapillary inlet rate, extracapillary circulation rate, rocker, and/or stop condition.

11. The non-transitory processor-readable storage medium as defined in claim 1 , wherein the providing the first setting for the first protocol as the first GUI element for selection comprises:
enabling the first GUI element for selection.

12. The non-transitory processor-readable storage medium as defined in claim 11 , wherein the enabling the first GUI element for selection comprises:
associating a first visual indicator with the first GUI element; and
in response to determining the first setting can be modified, associating a second visual indicator with the first GUI element.

13. The non-transitory processor-readable storage medium as defined in claim 1 , wherein the providing, through the user interface, the diagram view of the cell expansion system for customizing the first protocol comprises:
depicting an intracapillary space of the bioreactor in the diagram view; and
depicting an extracapillary space of the bioreactor in the diagram view.

14. The non-transitory processor-readable storage medium as defined in claim 2 , the method further comprising:
receiving, through the user interface, a fifth selection of a second process.

15. The non-transitory processor-readable storage medium as defined in claim 14 , the method further comprising:
providing, through the user interface, a second diagram view of the cell expansion system for customizing the first protocol, comprising:
associating the second diagram view with the second process in the user interface.

16. A method of customizing a protocol for use with a cell expansion system, the method comprising:
receiving a first selection, in a user interface associated with the cell expansion system, to customize a first protocol for expanding a plurality of cells in a bioreactor of the cell expansion system, wherein the user interface is operable to display data and receive an input;
in response to receiving the first selection, providing, through the user interface, a diagram view of the cell expansion system for customizing the first protocol, comprising:
providing a first setting for the first protocol as a first graphical user interface (GUI) element for selection;
receiving, through the user interface, a second selection of the first GUI element;
receiving, through the user interface, a first value for the first GUI element;
receiving a third selection to execute the first protocol; and
executing the first protocol using the first value for the first setting to expand the plurality of the cells.

17. The method as defined in claim 16 , further comprising:
providing, through the user interface, one or more types of processes to add;
receiving, through the user interface, a fourth selection of a first process; and
in response to receiving the fourth selection, associating the diagram view with the first process.

18. The method as defined in claim 17 , wherein the one or more types of processes to add comprises: wash out lines, wash out lines through membrane, wash rapidly, harvest cells, add bolus, and/or custom.

19. The method as defined in claim 17 , further comprising:
receiving, through the user interface, a fifth selection of a second process; and
in response to receiving the fifth selection:
providing, through the user interface, a second diagram view of the cell expansion system for customizing the first protocol, comprising:
associating the second diagram view with the second process in the user interface.

20. The method as defined in claim 17 , further comprising:
determining the first setting is associated with a numeric value; and
in response to determining the first setting is associated with the numeric value, providing a data entry pad in the diagram view to receive the first value.

Assignees

• Terumo Bct Inc

Inventors

• Stanton Iv Edward Allan
• Antwiler Glen Delbert
• Howley Patrick J
• Kinzie Michael E
• Dodd Jon A
• Medina Casey V

Classifications

• C12M41/44 Primary

  of volume or liquid level · CPC title

• C12M23/42

  Integrated assemblies, e.g. cassettes or cartridges · CPC title

• C12M23/44

  Multiple separable units; Modules · CPC title

• C12M25/10

  Hollow fibers or tubes (hollow fiber modules in general B01D63/02) · CPC title

• C12M25/12

  the culture medium flowing outside the fiber or tube · CPC title