Antagonists of interleukin-2 receptor
US-9428567-B2 · Aug 30, 2016 · US
US11746137B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11746137-B2 |
| Application number | US-202117915808-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 31, 2021 |
| Priority date | Mar 31, 2020 |
| Publication date | Sep 5, 2023 |
| Grant date | Sep 5, 2023 |
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The present invention relates to changes in interleukin-2 alpha receptors and interleukin-2 analogs with increased binding affinity for interleukin-2 beta receptors.
Opening claim text (preview).
The invention claimed is: 1. An interleukin-2 analog comprising any one sequence selected from the group consisting of the amino acid sequences of SEQ ID NOs: 22, 53, 87, 89, 91, 99, 104, 105, and 106.
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression · CPC title
Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title
Interleukin · CPC title
Vectors or expression systems specially adapted for E. coli · CPC title
IL-2 · CPC title
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