Coatings

Patent metadata

Field	Value
Publication number	US-11744925-B2
Application number	US-202016773685-A
Country	US
Kind code	B2
Filing date	Jan 27, 2020
Priority date	Jan 28, 2019
Publication date	Sep 5, 2023
Grant date	Sep 5, 2023

Abstract

Lubricious coatings for medical devices and their uses are described.

First claim

We claim:

1. A coating formulation comprising:
a base coat including a copolymer of a first tetrahydrofurfuryl acrylate monomer and a second monomer including a functional group amenable to further derivatization and a plurality of reactive moieties, and
a top coat including a hydrophilic polymer containing less than two reactive moieties per molecule.

2. The coating formulation of claim 1 , wherein the copolymer has a molecular weight between about 15,000 g/mole and about 150,000 g/mole.

3. The coating formulation of claim 1 , wherein the top coat is atop the base coat.

4. The coating formulation of claim 1 , wherein the hydrophilic polymer is a protein, collagen, albumin, fibrin, elastin, polypeptide, oligonucleotide, polysaccharide, hyaluronic acid, gelatin, chitosan, alginate, cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, dextran, poly(ether), poly(ethylene glycol), poly(ethylene oxide), poly(propylene glycol), poly(lactam), poly(vinylpyrrolidone), poly(acrylate), poly(urethane), poly(anhydride), poly(amino acid), poly(carboxylic acid), poly(amide), poly(vinyl alcohol), poly(phosphazene), or a combination thereof.

5. The coating formulation of claim 1 , wherein the hydrophilic polymer has a molecular weight between about 500 amu to about 100,000 amu.

6. The coating formulation of claim 1 , providing about 50% or more increased lubricity to a device coated with the coating formulation as compared to the device prior to being coated with the coating formulation.

7. The coating formulation of claim 6 , wherein the device is a catheter or microcatheter.

8. The coating formulation of claim 6 , wherein the device is a medical device.

9. The coating formulation of claim 1 , wherein the top coat comprises a hydrophilic polymer containing less than 1 reactive moieties per molecule.

10. The coating formulation of claim 1 , wherein the second monomer is 4-hydroxybutyl acrylate, and the hydrophilic polymer containing less than two reactive moieties per molecule is a poly(ethylene glycol) containing less than two reactive moieties per molecule.

11. The coating formulation of claim 1 , wherein the top coat consists essentially of a hydrophilic polymer containing less than two reactive moieties per molecule.

12. The coating formulation of claim 1 , which reduces the maximum dynamic friction force by about 50% or more on a surface coated with the coating formulation as compared to the surface prior to being coated with the coating formulation.

13. The coating formulation of claim 1 , which reduces the maximum dynamic friction force by about 75% to about 99% on a thermoplastic surface coated with the coating formulation as compared to the thermoplastic surface prior to being coated with the coating formulation.

14. The coating formulation of claim 1 , which reduces the maximum dynamic friction force by about 90% to about 99% on a thermoplastic surface coated with the coating formulation as compared to the thermoplastic surface prior to being coated with the coating formulation.

15. The coating formulation of claim 1 , wherein the copolymer has a molecular weight between about 25,000 g/mole to about 100,000 g/mole.

16. The coating formulation of claim 1 , wherein the hydrophilic polymer has a molecular weight between about 1,000 amu to about 40,000 amu.

17. The coating formulation of claim 1 , wherein the top coat includes a reaction product of a mixture including a polyethylene glycol di-acrylate having a molecular weight of about 4,000 g/mole, a surfactant, benzophenone, and 1-hydroxycyclohexyl phenyl ketone.

18. The coating formulation of claim 1 , wherein the top coat includes a reaction product of a mixture including a polyethylene glycol acrylate having a molecular weight of about 20,000 g/mole, a surfactant, benzophenone, and 1-hydroxycyclohexyl phenyl ketone.

19. A coating formulation comprising:
a base coat including a copolymer of a first tetrahydrofurfuryl acrylate monomer and a second monomer including a functional group amenable to further derivatization and a plurality of reactive moieties, and
a top coat including a hydrophilic polymer containing less than two reactive moieties per molecule,
wherein the hydrophilic polymer has a molecular weight between about 1,000 amu to about 40,000 amu, and
wherein the coating formulation reduces the maximum dynamic friction force by about 50% or more on a surface coated with the coating formulation as compared to the surface prior to being coated with the coating formulation.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Plotkin Steve
• Hsu Emily

Classifications

• A61L29/085 Primary

  Macromolecular materials · CPC title

• A61L29/041

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• B05D3/067

  Curing or cross-linking the coating · CPC title

• B05D7/546

  each layer being cured, at least partially, separately · CPC title

• C09D133/14

  of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen · CPC title