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Therapeutic compositions and methods for pulmonary fibrosis
US11744807B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11744807-B2 |
| Application number | US-202117151172-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 17, 2021 |
| Priority date | Jan 17, 2020 |
| Publication date | Sep 5, 2023 |
| Grant date | Sep 5, 2023 |
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- Title
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Abstract
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The present invention discloses a method for therapeutic management of pulmonary fibrosis in mammals using a composition comprising iso-garcinol or octahydrocurcumin or a combination of iso-garcinol and octahydrocurcumin. The composition is very suitable for treating pulmonary fibrosis due to viral infections, specifically COVID 19 and for improving lung function during prognosis.
First claim
Opening claim text (preview).
We claim: 1. A method for therapeutic management of pulmonary fibrosis in a mammal in need thereof, said method comprising the step of administering a composition comprising isogarcinol or a combination of isogarcinol and octahydrocurcumin to the mammal to bring about a reduction in symptoms and features of pulmonary fibrosis. 2. The method of claim 1 , wherein the symptoms of pulmonary fibrosis are selected from the group consisting of shortness of breath, chronic dry and hacking cough, fatigue and weakness, chest discomfort, chest pain, loss of appetite, weight loss, aching joints and muscles, clubbing of the tips of the fingers or toes. 3. The method of claim 1 , wherein the features of pulmonary fibrosis include increased hypoxia, extracellular matrix generation and deposition of aberrant matrix, increased inflammation and influx of inflammatory markers, increased migration and proliferation of fibroblasts, increased mucus secretion and increased lung index. 4. The method of claim 3 , wherein the inflammatory markers are selected from the group consisting of TGF-β, IL-13, IL-1β, TNF-α, CCL-17. 5. The method as in claim 1 , wherein the mammal is human.
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Classifications
- A61K31/122Primary
having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin · CPC title
- A61K31/09Primary
having two or more such linkages · CPC title
Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger · CPC title
Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title
Drugs for disorders of the respiratory system · CPC title
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Frequently asked questions
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- What does patent US11744807B2 cover?
- The present invention discloses a method for therapeutic management of pulmonary fibrosis in mammals using a composition comprising iso-garcinol or octahydrocurcumin or a combination of iso-garcinol and octahydrocurcumin. The composition is very suitable for treating pulmonary fibrosis due to viral infections, specifically COVID 19 and for improving lung function during prognosis.
- Who is the assignee on this patent?
- Majeed Muhammed, Nagabhushanam Kalyanam, Bani Sarang, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/122. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 05 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).