Use of volatile compositions to limit or eliminate the perception of malodor

Patent metadata

Field	Value
Publication number	US-11744785-B2
Application number	US-201816760031-A
Country	US
Kind code	B2
Filing date	Nov 21, 2018
Priority date	Nov 22, 2017
Publication date	Sep 5, 2023
Grant date	Sep 5, 2023

Abstract

The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.

First claim

The invention claimed is:

1. A method to inhibit, reduce, or suppress the perception of a malodor in a subject, comprising contacting the subject with at least one compound having the structure:

in a form of any one of the stereoisomers or as a mixture thereof,
wherein the index m represents 0 or 1;
wherein R 1 and R 2 represent, independently from each other, a hydrogen atom or a methyl group;
wherein each R 3 represent, independently from each other, a hydrogen atom or a C 1-4 alkyl or alkenyl group,
wherein the at least one compound is contacted in an amount sufficient to inhibit, reduce, or suppress the subject's perception of the malodor.

2. The method of claim 1 , wherein the contacting inhibits at least one olfactory receptor in the subject.

3. A method to inhibit at least one olfactory receptor in a subject, comprising contacting the subject with at least one compound having the structure:

in a form of any one of the stereoisomers or as a mixture thereof,
wherein the index m represents 0 or 1;
wherein R 1 and R 2 represent, independently from each other, a hydrogen atom or a methyl group;
wherein each R 3 represent, independently from each other, a hydrogen atom or a Ci-4 alkyl or alkenyl group,
wherein the at least one olfactory receptor is a butyric acid olfactory receptor, and
wherein the at least one compound is contacted in an amount sufficient to inhibit the at least one olfactory receptor.

4. The method of claim 2 , wherein the inhibition of the at least one olfactory receptor inhibits, reduces, suppresses, the perception of a malodor in a subject.

5. The method of claim 1 , wherein the malodor is selected from the group consisting of: latrine malodor, laundry malodor, moldy malodor, and sweat malodor.

6. The method of claim 2 , wherein the at least one olfactory receptor is a butyric acid olfactory receptor.

7. The method of claim 6 , wherein the butyric acid olfactory receptor is selected from the group consisting of: the OR51E1 olfactory receptor and the Olfr558 olfactory receptor.

8. The method of claim 6 , wherein the at least one compound that inhibits the butyric acid olfactory receptor is selected from the group consisting of: 2,2-dimethyl-6,6-bis(2-methylprop-2-enyl)cyclohexan-1-one, 2,2-dimethyl-5,5-bis(2-methylprop-2-enyl)cyclopentan-1-one, 2-but-3-en-2-yl-6,6-dimethyl-2-prop-2-enylcyclohexan-1-one, a mixture of 2,2-dimethyl-5,5-bis(2-methylprop-2-enyl)cyclopentan-1-one and 2-but-3-en-2-yl-6,6-dimethyl-2-prop-2-enylcyclohexan-1-one, 2,2-bis(2-methyl-2-propen-1-yl)cyclohexanone, and combinations thereof.

9. The method of claim 1 , wherein the at least one compound is incorporated into a perfuming composition.

10. The method of claim 9 , wherein the perfuming composition comprises a malodor receptor antagonist system comprising at least one perfuming ingredient and a non-functional perfume accord.

11. The method of claim 9 , wherein the perfuming composition comprises:
(i) from about 2 wt % to about 85 wt %, of a malodor receptor antagonist system comprising at least one ingredient perfuming;
(ii) from about 15 wt % to 98 wt % of a functional perfume accord comprising at least 2 perfuming ingredient(s) wherein, the accord has a tonality selected from floral, citrus and jasmine; and
(iii) optionally a non-functional perfume accord.

Assignees

• Firmenich & Cie

Inventors

• Kao Huey-Ling
• Ruider Stefan Alexander
• Smith Ben
• Marr Gary
• Rogers Matthew
• Sheikh Mushhood
• Wu Zhenan
• Pfister Patrick
• Birkbeck Anthony Alexander
• Coulomb Julien

Classifications

• A61Q15/00

  Anti-perspirants or body deodorants (deodorisation of air A61L9/00) · CPC title

• A61Q13/00

  Formulations or additives for perfume preparations (essential oils or perfumes per se C11B9/00) · CPC title

• A61L9/01

  Deodorant compositions {(compositions released by contact with a liquid A61L9/05)} · CPC title

• A61K8/34

  Alcohols · CPC title

• A61K8/33 Primary

  containing oxygen · CPC title