Chromatography apparatus

Patent metadata

Field	Value
Publication number	US-11740210-B2
Application number	US-201816647983-A
Country	US
Kind code	B2
Filing date	Sep 21, 2018
Priority date	Sep 22, 2017
Publication date	Aug 29, 2023
Grant date	Aug 29, 2023

Abstract

Disclosed is a chromatography system ( 100 ) comprising: plural modules ( 1 - 25 ) including at least one pump and a column valve unit ( 8 ) connectable to plural chromatography columns; and a controller ( 600 ), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing ( 110 ) into which the plural modules ( 1 - 25 ) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.

First claim

The invention claimed is:

1. A chromatography system comprising: plural modules including at least one pump and a column valve unit connectable to plural chromatography columns; and a controller, the controller being operable to control the at least one pump and the column valve unit to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said column valve unit, wherein the controller is further operable to perform column packing, column packing testing, or a combination thereof.

2. The chromatography system as claimed in claim 1 , wherein said selective valve opening allows a reversal of flow directions in use in one or more of said plural chromatography columns.

3. The chromatography system as claimed in claim 1 , further comprising a controller operable to control said modules according to software, and a display screen, said software being suitable to display plural icons on said screen and allowing user manipulation of the icon on the screen to drag and drop the icons to form a series of icons representative of a user defined chromatography control method.

4. The chromatography system as claimed in claim 3 , wherein the user defined method includes a continuous chromatography process employing said two or more chromatography columns.

5. The chromatography system as claimed in claim 1 , further comprising plural chromatography columns, each column including a chamber of changeable volume for housing chromatographic separation media and an adapter moveable to increase or decrease each said volume, and wherein the column valve unit is in fluid communication with each said adapter and is selectively operable to move independently or collectively each said adapter by means of fluid pressure changes to consequently change each said volume and in use to cause compression or relief from compression of media within each said column volume.

Assignees

• Ge Healthcare Bio Sciences Ab
• Cytiva Sweden Ab

Inventors

• Stafstrom Nils
• Rosengren Lars Olof Nils
• Erickson Kerstin Elisabet
• Agren Tomas Yngve
• Hareland Yngve L
• Francois Tim
• Jonsson Anita
• Cheng Jeanne
• Andersson Anna

Classifications

• G01N30/02

  Column chromatography · CPC title

• G01N30/44 Primary

  using recycling of the fraction to be distributed · CPC title

• G01N30/32

  of pressure or speed (G01N30/36 takes precedence) · CPC title

• G01N30/46

  using more than one column {(G01N30/44 takes precedence)} · CPC title

• G01N30/6052

  body · CPC title