Sample pre-compression valve for liquid chromatography

Patent metadata

Field	Value
Publication number	US-11733214-B2
Application number	US-202218145890-A
Country	US
Kind code	B2
Filing date	Dec 23, 2022
Priority date	Jan 29, 2016
Publication date	Aug 22, 2023
Grant date	Aug 22, 2023

Abstract

A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.

First claim

What is claimed is:

1. A sample pre-compression valve for liquid chromatography, the sampler comprising:
(a) a stator; and
(b) a rotor, which are arranged next to each other along their circular surface and which can be rotated against each other along their circular surface, wherein
the stator comprises at least five ports A, B, C, D and E and
the rotor comprises at least two grooves X and Y,
wherein the grooves X and Y are configured to respectively connect two of the ports A, B, C, D and E with each other and
wherein the ports can be embodied point-shaped or groove-shaped, characterized in that
(ii) the groove X connects the ports A and B in a valve position 2, in such a way that there are dead volumes present in the groove X and so that the groove Y does or does not connect ports C and D, and
(iii) the groove X connects the ports A and E with each other in a valve position 3, in such a way so that there are no dead volumes present in the groove X and so that the groove Y does or does not connect the ports B and C.

2. The sample pre-compression valve of claim 1 , wherein there are no dead volumes in the connecting grooves in valve position 3.

3. The sample pre-compression valve of claim 1 , wherein the groove Y does not connect the ports C and D in valve position 2.

4. The sample pre-compression valve of claim 1 , wherein Position 3 enables an INJECT position in which the sample is applied on the chromatography column.

5. The sample-pre-compression valve of claim 1 , wherein the ports B, C, D and E are arranged on one or more circular path(s) around the center of the stator.

6. The sample pre-compression valve of claim 1 , wherein port A is essentially spaced equally far away from the ports B, C, D and E.

7. The sample pre-compression valve of claim 1 , wherein the sample pre-compression valve has at most five ports.

8. The sample pre-compression valve of claim 1 , wherein the valve has at most the two grooves X and Y.

9. The sample pre-compression valve of claim 1 , wherein the groove X has a hook-shape.

10. The sample pre-compression valve of claim 1 , wherein the groove Y is designed line-shaped or arched, whereas the two end points are respectively arranged on a circular path around the center of the ring-shaped rotor.

11. The sample pre-compression valve of claim 1 , wherein the groove X connects the ports A and C with each other in groove X in a valve position 5, in such a way that no dead volumes are present, and so that the groove Y connects the ports D and E with each other.

12. The sample pre-compression valve of claim 1 , wherein the groove X connects the ports A and B with each other in a valve position 1, in such a way that there are no dead volumes present in the groove X and so that the groove Y does or does not connect the ports C and D.

13. The sample pre-compression valve of claim 12 , wherein the groove Y connects the ports C and D in valve position 1.

14. The sample pre-compression valve of claim 1 , wherein the groove Y connects the ports C and B in valve position 3.

15. The sample pre-compression valve of claim 14 , wherein ports C and E are arranged on opposites sides relative to the port A and that both are essentially spaced equally far away from the ports B and D respectively.

16. The sample pre-compression valve of claim 1 , wherein port A is arranged at a center of the stator.

17. The sample pre-compression valve of claim 16 , wherein the ports B, C, D and E can be arranged on the same circular path around the center of the stator.

18. A sampler for liquid chromatography, the sampler comprising:
(A) a sample pre-compression valve comprising:
(a) a stator; and
(b) a rotor, which are arranged next to each other along their circular surface and which can be rotated against each other along their circular surface, wherein
the stator comprises at least five ports A, B, C, D and E and
the rotor comprises at least two grooves X and Y,
wherein the grooves X and Y are configured to respectively connect two of the ports A, B, C, D and E with each other and
wherein the ports can be embodied point-shaped or groove-shaped, characterized in that
(ii) the groove X connects the ports A and B in a valve position 2, in such a way that there are dead volumes present in the groove X and so that the groove Y does or does not connect ports C and D, and
(iii) the groove X connects the ports A and E with each other in a valve position 3, in such a way so that there are no dead volumes present in the groove X and so that the groove Y does or does not connect the ports B and C;

(B) a sample loop with a sample conveying system and a needle seat;
(C) a solvent pump;
(D) a chromatography column; and
(E) a sample discharge line.

19. The sampler of claim 18 , wherein the solvent pump and the chromatography column are connected through grooves X and Y in valve position 3.

Assignees

• Dionex Softron Gmbh

Inventors

• Wachinger Thomas

Classifications

• G01N30/20 Primary

  using a sampling valve · CPC title

• G01N30/22

  in high pressure liquid systems · CPC title

• G01N30/32

  of pressure or speed (G01N30/36 takes precedence) · CPC title

• G01N2030/027

  Liquid chromatography · CPC title

• G01N2030/207

  with metering cavity, e.g. sample loop · CPC title