Method Of Maintaining Narrow Residence Time Distributions In Continuous Flow Systems
US-2020061495-A1 · Feb 27, 2020 · US
Mechanical method of maintaining narrow residence time distributions in continuous flow systems
US11732003B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11732003-B2 |
| Application number | US-201816610616-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 18, 2018 |
| Priority date | May 11, 2017 |
| Publication date | Aug 22, 2023 |
| Grant date | Aug 22, 2023 |
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Abstract
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Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for inactivating one or more viruses in a sample containing a target molecule, wherein the method comprises continuously exposing said sample to virus inactivation conditions, followed by causing the sample to flow in a flow channel in discrete packets by applying compressive force to the flow channel during a process for purifying said target molecule, wherein said compressive force is caused by compressing tubing coiled around a mandrel, said tubing defining said flow channel. 2. The method of claim 1 , wherein said flow channel has an outer wall, and wherein said compressive force is created by pinching said outer wall. 3. The method of claim 2 , comprising pinching said outer wall with one or more rollers.
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Classifications
Liquid substances · CPC title
Heat (radiation A61L2/08) · CPC title
Living organisms or biological materials · CPC title
Ultraviolet [UV] radiation · CPC title
- C07K1/22Primary
Affinity chromatography or related techniques based upon selective absorption processes · CPC title
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- What does patent US11732003B2 cover?
- Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minim…
- Who is the assignee on this patent?
- Emd Millipore Corp
- What technology area does this patent fall under?
- Primary CPC classification C07K1/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 22 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).