Modular continuous flow device

Patent metadata

Field	Value
Publication number	US-11731101-B2
Application number	US-201716080708-A
Country	US
Kind code	B2
Filing date	Feb 27, 2017
Priority date	Feb 29, 2016
Publication date	Aug 22, 2023
Grant date	Aug 22, 2023

Abstract

The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for connecting the continuous flow modules to each other in a parallel or radial manner. This arrangement allows conducting chemical reaction sequences by pre-synthesizing and intermediately storing or simultaneously synthesizing at least one intermediate product which is needed in the main synthetic reaction sequence in order to obtain the final product.

First claim

What is claimed is:

1. A modular continuous flow device for multistep synthesis comprising:
a) a plurality of continuous flow modules ( 1 );
b) a reagent supply system ( 2 );
c) a valve assembly ( 3 );
d) means for controlling flow rates and/or pressure ( 4 );
wherein each continuous flow module ( 1 ) is connected to the valve assembly ( 3 ) by at least one inlet and by at least one outlet;
wherein the continuous flow modules ( 1 ) are in a parallel arrangement; and
wherein the reagent supply system ( 2 ) is connected to the valve assembly ( 3 ) by one or more inlets and can be connected to at least one continuous flow module ( 1 ) by one or more inlets.

2. The modular continuous flow device according to claim 1 , wherein the continuous flow modules ( 1 ) further comprise at least one flow reactor for intermediate product storage ( 5 ).

3. The modular continuous flow device according to claim 1 , wherein the continuous flow modules ( 1 ) comprise at least one flow reactor for heating, at least one flow reactor for cooling, at least one flow reactor for photochemical reactions, at least one flow reactor for microwave irradiation, at least one flow reactor for electrochemical reactions, at least one flow reactor that is a tube-in-tube reactor, and at least one flow reactor that is a packed-bed reactor.

4. The modular continuous flow device according to claim 1 , wherein the continuous flow modules ( 1 ) are only connected to each other through the valve assembly ( 3 ).

5. The modular continuous flow device according to claim 1 , wherein any of continuous flow modules ( 1 ) is not directly connected to any other continuous flow module.

6. The modular continuous flow device according to claim 3 , wherein the at least one flow reactor for intermediate product storage ( 5 ), stores the intermediate product ( 21 ) under flow conditions in a closed circuit.

7. The modular continuous flow device according to claim 1 , wherein the means for controlling flow rates and/or pressure ( 4 ) are adapted to use a different flow rate and/or a different pressure in each continuous flow module ( 1 ).

8. The modular continuous flow device according to claim 1 further comprising at least one workup module ( 7 ).

9. The modular continuous flow device according to claim 1 , wherein the valve assembly ( 3 ) consists of at least one multiport switch valve equipped with a mixer and/or equipped with a splitter.

10. The modular continuous flow device according to claim 1 , wherein the reagent supply system ( 2 ) is connected to an input port of the valve assembly ( 3 ) through an injection loop ( 13 ) or through a charging station ( 15 ).

11. The modular continuous flow device according to claim 1 , further comprising mixers installed at the output of each continuous flow module ( 1 ) for reducing dispersion effects.

12. The modular continuous flow device according to claim 1 , further comprising at least one detector ( 6 ) for monitoring the reaction progress, wherein the at least one detector has one input and one output which are connected to the valve assembly ( 3 ) over two different fluid connections.

Assignees

• Max Planck Gesellschaft

Inventors

• Gilmore Kerry
• Seeberger Peter H
• Pieber Bartholomaus
• Chatterjee Sourav

Classifications

• B01J19/0046 Primary

  Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays (synthesis methods per se C40B50/00) · CPC title

• B01J19/126

  Microwaves · CPC title

• B01J2219/00033

  Continuous processes · CPC title

• B01J2219/0072

  Organic compounds · CPC title

• B01J2219/00281

  Individual reactor vessels · CPC title