Gamma stimulation pulsing light source system with dosage adjustment for gaze angle

Patent metadata

Field	Value
Publication number	US-11730917-B2
Application number	US-202017084275-A
Country	US
Kind code	B2
Filing date	Oct 29, 2020
Priority date	Oct 29, 2020
Publication date	Aug 22, 2023
Grant date	Aug 22, 2023

Abstract

Gamma brain stimulation for preventing or treating Alzheimer's disease or sleeping disorders using light or sound is known. A strobing 40 Hz light source has been shown to cause positive effects due to the stimulation. It is an advantage to know the actual dosage of light that enters the person's eyes in order to understand the relationship between dosage and effectiveness. A camera is used to detect the subject's gaze angle, distance, pupil diameter and any other factors that affect the light power that enters the eye. A target dosage is first determined by a medical worker, such as to determine the effects of the exact same dosage on a group of similar persons, such as Alzheimer's patients. With deviations of gaze angle, distance, and pupil size from the ideal, the effective dosage is decreased. The disclosed system adjusts the actual dosage, such as session duration, based on such factors so that the final dosage received by the person is consistent and meets the target dosage.

First claim

What is claimed is:

1. An optical gamma brain stimulation system for a person comprising:
a processing system;
a visible-wavelength light source configured to strobe at a brain stimulation rate between 13-140 Hz, the light source being remote from the person so as not to be supported by the person; and
an eye-tracking device being remote from the person so as not to be supported by the person, the eye-tracking device being configured to detect an eye of the person and provide first data to the processing system as light from the light source is received into the eye of the person, the eye-tracking device comprising a camera and the processing system, wherein the eye-tracking device is configured to sense a gaze angle of the person with respect to the light source and an eye distance from the light source during a brain stimulation session, wherein the gaze angle and the eye distance are encoded in the first data,
wherein the processing system is configured to detect a deviation in the gaze angle and the eye distance in real-time, correlate the deviation with a reduction of therapeutically effective light dosage, and automatically extend a duration of the brain stimulation session based on the first data and detected deviation as a dose correction measure to provide a pre-programmed therapeutically effective target light dosage to the person irrespective of the gaze angle and the eye distance with respect to the light source deviating from a designated gaze angle and eye distance required to deliver the therapeutically effective target light dosage to the person.

2. The stimulation system of claim 1 , wherein the brain stimulation rate is between 20-140 Hz.

3. The stimulation system of claim 1 , wherein the first data further encodes the person's pupil size.

4. The stimulation system of claim 1 further comprising a display of the duration of the brain stimulation session as the session duration is extended.

5. The stimulation system of claim 1 further comprising a memory, wherein second data corresponding to the brain stimulation session is stored in the memory for later retrieval.

6. The stimulation system of claim h wherein the brain stimulation system is used for treating effects of Alzheimer's disease, or preventing Alzheimer's disease, or treating a sleeping disorder.

7. The stimulation system of claim 1 further comprising a communications system, wherein the communications system transmits second data relating to the session for use in determining an efficacy of brain stimulation.

8. An optical gamma brain stimulation method for a person comprising:
strobing a visible-wavelength light source at a brain stimulation rate between 13-140 Hz, the light source being remote from the person so as not to be supported by the person;
detecting a gaze angle and an eye distance from the light source, using an eye-tracking device, to provide first data to a processing system as light from the light source is received into the person's eye, the eye-tracking device being remote from the person so as not to be supported by the person, the eye-tracking device comprising a camera and the processing system, wherein the eye-tracking device senses the sgaze angle with respect to the light source and the eye distance from the light source during a brain stimulation session, such that the gaze angle and the eye distance are encoded in the first data; and
correlating, via the processing system, a deviation detected in real-time in the gaze angle and the eye distance with a reduction of therapeutically effective light dosage,
automatically determining a dose correction measure by extending a duration of the brain stimulation session based on the first data and detected deviation; and
causing the light source to provide a pre-programmed therapeutically effective target light dosage to the person irrespective of the detected gaze angle and the detected eye distance deviating from a designated gaze angle and eye distance required to deliver the therapeutically effective target light dosage to the person.

9. The stimulation method of claim 8 , wherein the first data further encodes the person's pupil size.

10. The stimulation method of claim 8 , wherein the brain stimulation method is used for treating effects of Alzheimer's disease, or preventing Alzheimer's disease, or treating a sleeping disorder.

Assignees

• Optoceutics ApS
• Univ Denmark Tech Dtu

Inventors

• Carstensen Marcus
• Petersen Paul Michael
• Broeng Jes
• Henney Mark
• Nguyen Ngoc Mai
• Dobkin Robert

Classifications

• A61M21/02 Primary

  for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia (for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021) · CPC title

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title

• G16H20/70

  relating to mental therapies, e.g. psychological therapy or autogenous training · CPC title

• G16H40/67

  for remote operation · CPC title

• A61B3/112

  for measuring diameter of pupils · CPC title