Bubble jetting member and method for producing same, gas/liquid jetting member and method for producing same, localized ablation device and localized ablation method, injection device and injection method, plasma-bubble jetting member, and therapeutic device and therapeutic method

Patent metadata

Field	Value
Publication number	US-11730531-B2
Application number	US-202016884365-A
Country	US
Kind code	B2
Filing date	May 27, 2020
Priority date	Mar 2, 2012
Publication date	Aug 22, 2023
Grant date	Aug 22, 2023

Abstract

Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma.Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage. By further providing an outside shell part at the outer periphery of the shell part, bubbles onto which a solution containing an injection substance has been adsorbed can be ejected, and the injection substance can be introduced during localized ablation of the process target. Additionally, by including a pair of electrodes formed from a conducting material, for generating a plasma in an inert gas, a liquid flow passage through which a liquid flows, and a microscopic flow passage for flow of an inert gas, an inert gas containing a plasma, and bubbles of inert gas containing a plasma, the liquid flow passage and the microscopic flow passage connecting at the downstream side from a section in which plasma is generated in the microscopic flow passage, bubbles containing a plasma can be generated, and can maintain a plasma state even in liquid, whereby therapy of biological tissue can be effected with the plasma.

First claim

What is claimed is:

1. A device comprising a plasma bubble jetting member, comprising:
a substrate;
a pair of electrodes formed from a conducting material, and adapted for generating a plasma in an inert gas;
a liquid flow passage on the substrate through which a liquid flows; and
a microscopic flow passage on the substrate comprising a first portion through which flows an inert gas and which contains the pair of electrodes, and a second downstream portion through which flows an inert gas, an inert gas containing a plasma, and a liquid containing bubbles of an inert gas containing a plasma;
the liquid flow passage and the microscopic flow passage connecting at a downstream side from a section in which the plasma is generated in the microscopic flow passage.

2. The device according to claim 1 , wherein the microscopic flow passage includes a plasma reservoir in which the section in which the plasma is generated is made larger than the rest of the microscopic flow passage.

3. The device of claim 2 which is a localized ablation device.

4. A localized ablation or therapeutic method, comprising:
causing an inert gas to flow into a microscopic flow passage of a device comprising a plasma bubble jetting member which comprises:
a substrate;
a pair of electrodes formed from a conducting material, and adapted for generating a plasma in an inert gas;
a liquid flow passage on the substrate through which a liquid flows; and
a microscopic flow passage on the substrate comprising a first portion through which flows an inert gas and which contains the pair of electrodes, and a second downstream portion through which flows an inert gas, an inert gas containing a plasma, and a liquid containing bubbles of an inert gas containing a plasma;

 the liquid flow passage and the microscopic flow passage connecting at a downstream side from a section in which the plasma is generated in the microscopic flow passage;
applying a high-frequency electrical pulse to the pair of electrodes to generate a plasma in the inflowing gas;
causing the inert gas containing the plasma to flow into a liquid in the liquid flow channel which connects to the microscopic flow passage, to generate bubbles containing plasma; and
(a) processing a target with the bubbles containing plasma to effect localized ablation or (b) effecting therapy of the biological tissue with the bubbles containing plasma.

5. The device of claim 2 which is a therapeutic device.

6. The device according to claim 2 , wherein the electrode is of a size at least sufficient to cover the plasma reservoir.

7. The device of claim 6 which is a localized ablation device.

8. The localized ablation or therapeutic method of claim 4 , wherein the microscopic flow passage includes a plasma reservoir in which the section in which the plasma is generated is made larger than the rest of the microscopic flow passage.

9. The device of claim 6 which is a therapeutic device.

10. The device of claim 1 which is a localized ablation device.

11. The localized ablation or therapeutic method of claim 8 , wherein the electrode is of a size at least sufficient to cover the plasma reservoir.

12. The device of claim 1 which is a therapeutic device.

13. A plasma bubble jetting member, comprising:
a substrate;
a pair of electrodes formed from a conducting material, and adapted for generating a plasma in an inert gas;
a liquid flow passage on the substrate through which a liquid flows; and
a microscopic flow passage on the substrate comprising a first portion extending through a center flow direction axis and through which flows an inert gas, and which contains the pair of electrodes, and a second downstream portion through which flows an inert gas, an inert gas containing a plasma, and a liquid containing bubbles of an inert gas containing a plasma along the center flow direction axis,

wherein the liquid flow passage connects and merges with the microscopic flow passage at a downstream side on the center flow direction axis from a section in which the plasma is generated in the microscopic flow passage.

14. The device according to claim 1 , wherein in the plasma bubble jetting member an angle of a section in which the microscopic flow passage and the liquid flow passage connect is at least greater than 0 degrees but not more than 90 degrees.

15. The device according to claim 14 , wherein an angle of a section in which the microscopic flow passage and the liquid flow passage connect is 20-90 degrees.

16. The device according to claim 1 , wherein in the plasma bubble jetting member two or more fluid flow channels are formed.

Assignees

• Japan Science & Tech Agency

Inventors

• Yamanishi Yoko
• Sakuma Shinya
• KURIKI Hiroki
• Arai Fumihito

Classifications

• A61B18/042 Primary

  using additional gas becoming plasma · CPC title

• A61B18/12

  by passing a current through the tissue to be heated, e.g. high-frequency current · CPC title

• A61M5/30

  Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules · CPC title

• A61N1/44

  Applying ionised fluids {(ion generators H01J37/00)} · CPC title

• C12M35/04

  Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli · CPC title