(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
US-11084810-B2 · Aug 10, 2021 · US
US11725004B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11725004-B2 |
| Application number | US-202117398155-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 10, 2021 |
| Priority date | May 17, 2013 |
| Publication date | Aug 15, 2023 |
| Grant date | Aug 15, 2023 |
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This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.
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The invention claimed is: 1. A method of treating diabetic neuropathy, comprising administering to a human being an effective amount of a compound selected from the group consisting of and a pharmaceutically acceptable salt thereof, to treat the diabetic neuropathy. 2. The method of claim 1 , wherein the compound is 3. The method of claim 1 , wherein the compound is administered in the form of a tablet, pill, or capsule. 4. The method of claim 2 , wherein the compound is administered in the form of a tablet, pill, or capsule. 5. A method of treating neuropathic pain due to diabetic peripheral neuropathy, comprising administering to a human being an effective amount of a compound selected from the group consisting of and a pharmaceutically acceptable salt thereof, to treat the neuropathic pain due to diabetic peripheral neuropathy. 6. The method of claim 5 , wherein the compound is 7. The method of claim 5 , wherein the compound is administered in the form of a tablet, pill, or capsule. 8. The method of claim 6 , wherein the compound is administered in the form of a tablet, pill, or capsule. 9. A method of treating neuropathic pain due to diabetic neuropathy, comprising administering to a human being an effective amount of a compound selected from the group consisting of and a pharmaceutically acceptable salt thereof, to treat the neuropathic pain due to diabetic neuropathy. 10. The method of claim 9 , wherein the compound is 11. The method of claim 9 , wherein the compound is administered in the form of a tablet, pill, or capsule. 12. The method of claim 10 , wherein the compound is administered in the form of a tablet, pill, or capsule. 13. A method of treating nerve injury-induced neuropathic pain, comprising administering to a human being an effective amount of a compound selected from the group consisting of and a pharmaceutically acceptable salt thereof, to treat the nerve injury-induced neuropathic pain. 14. The method of claim 13 , wherein the compound is 15. The method of claim 13 , wherein the compound is administered in the form of a tablet, pill, or capsule. 16. The method of claim 14 , wherein the compound is administered in the form of a tablet, pill, or capsule.
linked by a chain containing hetero atoms as chain links · CPC title
not condensed and containing further heterocyclic rings · CPC title
having one double bond between ring members or between a ring member and a non-ring member · CPC title
Nitrogen atoms · CPC title
containing two hetero rings · CPC title
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