Method for extraction and purification of 68GA

Patent metadata

Field	Value
Publication number	US-11723992-B2
Application number	US-201917265138-A
Country	US
Kind code	B2
Filing date	Aug 2, 2019
Priority date	Aug 3, 2018
Publication date	Aug 15, 2023
Grant date	Aug 15, 2023

Abstract

Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.

First claim

What is claimed is:

1. A method of preparing a purified, carrier-free 68 Ga solution comprising:
a) obtaining a 68 Ga solution to be purified comprising 68 Ga;
b) contacting the 68 Ga solution with an anion-exchange resin, wherein the anion-exchange resin comprises a phosphonate or a substituted phosphonate; and
c) eluting the 68 Ga from the anion-exchange resin to obtain the purified, carrier-free 68 Ga solution.

2. The method of claim 1 , wherein the method comprises contacting the 68 Ga solution to be purified with a single anion-exchange resin.

3. The method of claim 1 , wherein the method does not comprise contacting the 68 Ga solution to be purified or the purified, carrier-free 68 Ga solution with another ion-exchange resin.

4. The method of claim 1 , wherein the 68 Ga in the 68 Ga solution to be purified is prepared by synthesizing the 68 Ga in the 68 Ga solution.

5. The method of claim 4 , wherein a cyclotron is used to synthesize the 68 Ga.

6. The method of claim 5 , wherein the cyclotron comprises a metal sample in the form of a liquid target.

7. The method of claim 6 , wherein the metal sample comprises 68 Zn 2+ .

8. The method of claim 5 , wherein the cyclotron comprises a metal sample in the form of a solid target.

9. The method of claim 8 , wherein the metal sample comprises 68 Zn.

10. The method of claim 1 , wherein the 68 Ga solution to be purified comprises an acid.

11. The method of claim 1 , wherein the 68 Ga solution to be purified is an aqueous solution.

12. The method of claim 1 , wherein the anion-exchange resin comprises a phosphonate.

13. The method of claim 12 , wherein the anion-exchange resin comprises dipentyl pentylphosphonate.

14. The method of claim 1 , wherein the method further comprises washing the anion-exchange resin with a washing solution.

15. The method of claim 1 , wherein the purified, carrier-free 68 Ga solution has an activity of from about 37 MBq to about 370 GBq.

Assignees

• Univ Texas

Inventors

• Lin Mai
• Gonzalez-Lepera Carlos E

Classifications

• A61K51/088 Primary

  conjugates with carriers being peptides, polyamino acids or proteins (antibodies A61K51/10) · CPC title

• A61K51/0402

  carboxylic acid carriers, fatty acids (amino acids A61K51/0406) · CPC title

• A61K51/048

  DTPA (diethylenetriamine tetraacetic acid) · CPC title

• A61K51/0482

  chelates from cyclic ligands, e.g. DOTA · CPC title

• A61K51/08

  Peptides, e.g. proteins {, carriers being peptides, polyamino acids, proteins} · CPC title