Method for measuring a biomarker in a biological sample of an IPAF patient

Patent metadata

Field	Value
Publication number	US-11719706-B2
Application number	US-202016847994-A
Country	US
Kind code	B2
Filing date	Apr 14, 2020
Priority date	Apr 25, 2019
Publication date	Aug 8, 2023
Grant date	Aug 8, 2023

Abstract

Disclosed is a method for measuring a biomarker in a biological sample of the IPAF patient, wherein the biomarker comprises at least one selected from the group consisting of CXCL9 and CXCL10, and a measurement result of the biomarker is used as an index for determining treatment responsiveness to anti-inflammatory therapy.

First claim

What is claimed is:

1. A method for treating an interstitial pneumonia with autoimmune features (IPAF) patient with anti-inflammatory therapy, comprising:
measuring at least one biomarker in a biological sample of an IPAF patient, wherein the biomarker is CXCL9;
comparing a measured value of CXCL9 with a predetermined threshold value;
determining that the patient may be responsive to an anti-inflammatory treatment based on a result of the comparing step, wherein the result comprises the measured value of CXCL9 being greater than or equal to a predetermined threshold value; and
treating the patient with the anti-inflammatory therapy based on the result of the comparing step, wherein the result comprises the measured value of CXCL9 being greater than or equal to the predetermined threshold value.

2. The method according to claim 1 , wherein the anti-inflammatory therapy comprises administering an immunosuppressant to the patient.

3. The method according to claim 2 , wherein the immunosuppressant is a steroid.

4. The method according to claim 1 , wherein the biological sample is a blood sample.

Assignees

• Univ Sapporo Medical
• Sysmex Corp

Inventors

• Kameda Masami
• Otsuka Mitsuo
• Hasegawa Takehiro

Classifications

• G01N33/6893 Primary

  related to diseases not provided for elsewhere · CPC title

• G01N33/6863

  Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors · CPC title

• G01N2333/7158

  for chemokines · CPC title

• G01N2800/12

  Pulmonary diseases · CPC title

• G16B20/00 Primary

  ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations · CPC title