Measuring light scattering of a sample

Patent metadata

Field	Value
Publication number	US-11719631-B2
Application number	US-202117477528-A
Country	US
Kind code	B2
Filing date	Sep 16, 2021
Priority date	Sep 16, 2020
Publication date	Aug 8, 2023
Grant date	Aug 8, 2023

Abstract

The present disclosure describes a computer implemented method, a system, and a computer program product of measuring light scattering of a sample.

First claim

What is claimed is:

1. A computer implemented method comprising:
displaying, by a computer system, at least one graphic,
wherein the at least one graphic is one of an alarms graphic, a size graphic, a molar mass graphic, a presets graphic, an experiments graphic, and a settings graphic, on a display logically coupled to a light scattering measurement instrument, thereby resulting in a graphics page,
wherein the instrument is configured to measure at least one of dynamic light scattering, static light scattering, and electrophoretic light scattering, of at least one sample, resulting in a light scattering measurement;

in response to receiving, by the computer system, a selection command corresponding to the alarms graphic, displaying, by the computer system, on the display an alarms page;
in response to receiving, by the computer system, a selection command corresponding to the size graphic, displaying, by the computer system, on the display a size workflow page displaying a guided size workflow,
wherein the guided size workflow comprises size functions corresponding to size parameter commands to direct the instrument to take at least one size measurement in light of entered size parameter commands corresponding to the size functions;

in response to receiving, by the computer system, a selection command corresponding to the molar mass graphic, displaying, by the computer system, on the display a molar mass workflow page displaying a guided molar mass workflow,
wherein the guided molar mass workflow comprises molar mass functions to direct the instrument to take at least one molar mass measurement in light of entered molar mass parameter commands corresponding to the molar mass parameter commands;

in response to receiving, by the computer system, a selection command corresponding to the presets graphic, displaying, by the computer system, on the display a presets page configured to provide access to at least one saved workflow;
in response to receiving, by the computer system, a selection command corresponding to the experiments graphic, displaying, by the computer system, on the display an experiments page configured to display results obtained during at least one saved experiment and configured to provide access to the results; and
in response to receiving, by the computer system, a selection command corresponding to the settings graphic, displaying, by the computer system, on the display a settings page configured to display instrument settings and configured to allow for modifying at least one setting of the instrument.

2. The method of claim 1 wherein the displaying the alarms page comprises
displaying, by the computer system, on the display, at least one of at least one active instrument alarm and at least one historical alarm, corresponding to the measurement.

3. The method of claim 1 wherein the size functions comprise
a cuvette function, a solvent function, a temperature function, a measurements function, and a summary function.

4. The method of claim 1 wherein the size parameter commands comprise a cuvette command, a solvent command, a temperature command, and a measurements command.

5. The method of claim 1 wherein the molar mass functions comprise
a cuvette function, a sample function, a solvent function, a temperature function, a measurements function, and a summary function.

6. The method of claim 1 wherein the molar mass parameter commands comprise a cuvette command, sample command, a solvent command, a temperature command, and a measurements command.

7. The method of claim 1 wherein the results obtained during the at least one saved experiment comprise a workflow and data corresponding to the at least one saved experiment.

8. The method of claim 1 further comprising:
displaying, by the computer system, on the display a progress graphic; and
in response to receiving, by the computer system, a selection command corresponding to the progress graphic, transmitting, by the computer system, a collect command to the instrument to collect data traces, instrument settings, experiment parameters, and instrument usage data for the measurement, resulting in a collection corresponding to the measurement, and to store the data traces, the instrument settings, the experiment parameters, and instrument usage data in a data store.

9. The method of claim 8 wherein the instrument usage data comprise at least one user id corresponding to a user of the instrument.

10. The method of claim 8 further comprising
displaying, by the computer system, on the display, a progress page configured to display an amount of time remaining until the collection is complete.

11. The method of claim 8 further comprising
transmitting, by the computer system, at least one status of the collection to a data sink.

12. The method of claim 10 further comprising
displaying, by the computer system, a results page allowing for at least one of displaying at least one of data and graphs of data of the collection and displaying at least one report of at least one of data and graphs of data of the collection.

13. The method of claim 1 further comprising
executing, by the computer system, a set of logical operations identifying each individual computer system among the plurality of client computer systems, by at least a session ID corresponding to the individual computer system and an IP address corresponding to the individual computer system.

14. The method of claim 3 wherein the summary function is configured to display, by the computer system on the display, at least one of a measurements graphic, a cuvette graphic, a temperature graphic, a solvent graphic, and a post collection graphic.

15. The method of claim 14 further comprising
displaying, by the computer system, on the display a start graphic and a cancel graphic.

16. The method of claim 5 wherein the summary function is configured to display, by the computer system on the display, at least one of a measurements graphic, a cuvette graphic, a temperature graphic, a sample type graphic, a solvent graphic, and a post-collection graphic.

17. The method of claim 16 further comprising
displaying, by the computer system, on the display a start graphic and a cancel graphic.

18. The method of claim 17 wherein in response to receiving, by the computer system, a selection command corresponding to the sample type graphic, executing, by the computer system, a set of logical operations allowing for selecting at least one of a workflow, measurement settings, and data filter settings, for the measurement.

19. The method of claim 1 further comprising
displaying, by the computer system, on the display a data quality graphic; and
in response to receiving, by the computer system, a selection command corresponding to the data quality graphic, displaying, by the computer system on the display, an assessment of results corresponding to the measurement.

20. The method of claim 1 wherein the guided workflow comprises
a workflow guided by a rule set corresponding to an interdependency among parameters of the measurement.

21. The method of claim 1 wherein the displaying further comprises
displaying, by the computer system, at least one of a zeta potential graphic, a molar mass and size graphic, and a zeta potential and size graphic.

Assignees

• Wyatt Tech Corp

Inventors

• Kahng Dwight
• Lee Cha
• Kuebler Sigrid C
• Bryant Ross E

Classifications

• G01N21/47 Primary

  Scattering, i.e. diffuse reflection (G01N21/25, G01N21/41 take precedence {G01N21/55 takes precedence}) · CPC title

• G06F3/04847

  Interaction techniques to control parameter settings, e.g. interaction with sliders or dials · CPC title

• G01N2201/126

  Microprocessor processing · CPC title

• G01N21/51 Primary

  inside a container, e.g. in an ampoule (G01N21/53 takes precedence) · CPC title

• G01N2021/4711

  Multiangle measurement · CPC title