Heterocyclic compounds as triggering receptor expressed on myeloid cells2 agonists and methods of use

US11718617B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11718617-B2
Application numberUS-202218072497-A
CountryUS
Kind codeB2
Filing dateNov 30, 2022
Priority dateMay 4, 2020
Publication dateAug 8, 2023
Grant dateAug 8, 2023

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

First claim

Opening claim text (preview).

What is claimed is: 1. A compound selected from: Ex. 3 Ex. 19 Ex. 22 Ex 23 Ex. 28 Ex. 49 Ex. 61 Ex. 77 Ex. 82 Ex. 94 Ex. 107 Ex. 117 Ex. 123 Ex. 124 Ex. 125 Ex. 126 Ex. 128 Ex. 129 Ex. 131 Ex. 133 Ex. 136 Ex. 137 Ex. 146 Ex. 149 Ex. 150 Ex. 151

Assignees

Inventors

Classifications

  • C07D519/00Primary

    Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 · CPC title

  • not condensed and containing further heterocyclic rings, e.g. timolol · CPC title

  • ortho- or peri-condensed with heterocyclic rings · CPC title

  • C07D471/04Primary

    Ortho-condensed systems · CPC title

  • containing three or more hetero rings · CPC title

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Frequently asked questions

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What does patent US11718617B2 cover?
The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthes…
Who is the assignee on this patent?
Amgen Inc, Vigil Neuroscience Inc
What technology area does this patent fall under?
Primary CPC classification C07D519/00. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Aug 08 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 9 related publications on this page (citations in our corpus or others sharing the same primary CPC).