Biological tissue transdermal patch

Patent metadata

Field	Value
Publication number	US-11717671-B2
Application number	US-201816606403-A
Country	US
Kind code	B2
Filing date	Apr 18, 2018
Priority date	Apr 21, 2017
Publication date	Aug 8, 2023
Grant date	Aug 8, 2023

Abstract

A biological tissue transdermal patch houses a battery part and an active ingredient such that they do not come into contact with each other. For the use of the biological tissue transdermal patch, the battery part and the active ingredient are brought into contact to start battery reaction of the battery part and the battery part is attached to a biological tissue. Carbonized bacterial cellulose or cellulose nanofiber carbon is used for a positive electrode of the battery part.

First claim

The invention claimed is:

1. A biological tissue transdermal patch which is to be used by being attached to a biological tissue, comprising:
a battery part; and
an active ingredient,
wherein the battery part includes:
a positive electrode;
a negative electrode;
an electrically-conductive layer; and
a separator, wherein a first portion of the separator is arranged in contact with the positive electrode and a second portion of the separator is arranged in contact with the negative electrode,

wherein in a first configuration for storage of the biological tissue transdermal patch, the separator includes no electrolyte and the active ingredient is housed out of contact with the battery part, and
wherein in a second configuration for use of the biological tissue transdermal patch, the active ingredient is brought into contact with the separator to start a battery reaction.

2. The biological tissue transdermal patch according to claim 1 , further comprising a container which includes a partition wall and which houses the battery part and the active ingredient together in the container while isolating the battery part and the active ingredient from each other in the first configuration, wherein
in the second configuration for the use of the biological tissue transdermal patch, the partition wall is at least partially removed to bring the active ingredient into contact with the battery part.

3. The biological tissue transdermal patch according to claim 1 , wherein
the first portion of the separator is a positive electrode separator which is arranged in contact with the positive electrode and out of contact with the negative electrode and the second portion of the separator is a negative electrode separator which is arranged in contact with the negative electrode and out of contact with the positive electrode, and
after the battery reaction is started, the biological tissue transdermal patch is configured to be used with the positive electrode separator and the negative electrode separator brought into contact with the biological tissue.

4. The biological tissue transdermal patch according to claim 3 , wherein the electrically-conductive layer has a liquid repelling property.

5. The biological tissue transdermal patch according to claim 1 , wherein
the electrically-conductive layer includes a positive electrode electrically-conductive layer which is arranged in contact with the positive electrode and out of contact with the negative electrode and a negative electrode electrically-conductive layer which is arranged in contact with the negative electrode and out of contact with the positive electrode, and
after the battery reaction is started, the biological tissue transdermal patch is configured to be used with the positive electrode electrically-conductive layer and the negative electrode electrically-conductive layer brought into contact with the biological tissue.

6. The biological tissue transdermal patch according to claim 1 , wherein the separator is formed of xerogel.

7. The biological tissue transdermal patch according to claim 1 , wherein the negative electrode contains at least one of magnesium, zinc, aluminum, iron, calcium, lithium, and sodium.

8. The biological tissue transdermal patch according to claim 1 , wherein the battery reaction generates magnesium hydroxide.

9. A biological tissue transdermal patch which is to be used by being attached to a biological tissue, comprising:
a battery par; and
an active ingredient,
wherein the battery part includes:
a positive electrode;
a negative electrode;
an electrically-conductive layer; and
a separator,

wherein in a first configuration for storage of the biological tissue transdermal patch, the separator includes no electrolyte and the active ingredient is housed out of contact with the battery part,
wherein in a second configuration for use of the biological tissue transdermal patch, the active ingredient is brought into contact with the separator to start a battery reaction, and
wherein the positive electrode contains carbonized cellulose with a three-dimensional network structure.

Assignees

• Nippon Telegraph & Telephone

Inventors

• Nohara Masaya
• Iwata Mikayo
• Hayashi Masahiko
• Komatsu Takeshi

Classifications

• A61N1/0448 Primary

  Drug reservoir · CPC title

• A61K9/0009

  involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title

• A61K9/7084

  Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches · CPC title

• A61N1/0432

  Anode and cathode · CPC title

• A61N1/0428 Primary

  Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs · CPC title