Argon combined with thrombectomy in the event of ischaemic stroke

Patent metadata

Field	Value
Publication number	US-11717635-B2
Application number	US-202017018311-A
Country	US
Kind code	B2
Filing date	Sep 11, 2020
Priority date	Sep 12, 2019
Publication date	Aug 8, 2023
Grant date	Aug 8, 2023

Abstract

The invention relates to an inhalable gaseous medicament containing argon gas for use in combination with a mechanical thrombectomy for treating, reducing or resorbing brain lesions subsequent to an ischaemic stroke in an individual. Preferably, the proportion by volume of argon is between 30 and 79%. The mechanical thrombectomy can be accompanied by a drug-based thrombolysis to dissolve the clot and to thin the blood of the patient.

First claim

What is claimed is:

1. A method for treating, reducing or resorbing brain lesions subsequent to an ischaemic stroke in an individual who subsequently undergoes a mechanical thrombectomy, said method comprising:
(a) administering a gaseous medicament containing Argon by inhalation after said ischaemic stroke,
(b) followed by performing the mechanical thrombectomy with a mechanical extraction of at least one portion of a blood clot resulting from the ischaemic stroke,

and in which the administration of the gaseous medicament containing Argon by inhalation:
i) is begun after an ischaemic stroke diagnosis, and
ii) is maintained throughout the thrombectomy,

characterized in that the gaseous medicament containing Argon is greater than 50% by volume Argon.

2. The method according to claim 1 , characterized in that the gaseous medicament containing Argon is mixed with a gas containing at least 21% by volume of oxygen.

3. The method according to claim 2 , characterized in that the gaseous medicament containing Argon is mixed with a gas containing 35 to 50% of oxygen.

4. The method according to claim 3 , characterized in that a final proportion by volume of Argon is equal to 60% and the proportion by volume of oxygen is equal to 40%.

5. The method according to claim 1 , characterized in that the gaseous medicament containing Argon is in a form suitable for inhaled administration by the nasal, buccal or pharyngeal route.

6. The method according to claim 1 , characterized in that the administration of the gaseous medicament containing Argon by inhalation is continued after a reperfusion subsequent to the mechanical extraction of the at least one portion of the blood clot resulting from the ischaemic stroke.

7. The method according to claim 6 , characterized in that the administration of the gaseous medicament containing Argon by inhalation is continued for at least 30 minutes after reperfusion.

8. The method according to claim 1 , characterized in that the gaseous medicament containing Argon is packaged in a pressurized gas container.

9. The method according to claim 1 , characterized in that the individual is an adult, an adolescent or a child.

10. The method according to claim 1 , characterized in that the mechanical thrombectomy comprises the mechanical extraction of the entire blood clot resulting from the ischaemic stroke.

11. The method according to claim 1 , characterized in that the mechanical thrombectomy is combined with a drug-based thrombolysis.

12. The method according to claim 1 , characterized in that the method comprises a step of confirming an ischaemic stroke diagnosis by brain imaging prior to step (a).

13. The method according to claim 1 , characterized in that the method comprises administering an anaesthetic to the individual.

Assignees

• Air Liquide
• Aix Marseille Univ
• Centre Nat Rech Scient
• Lair Liquide Soc Pour Letude Et Lexploitation Des Procedes Georges Claude

Inventors

• Farjot Géraldine
• Billoet Catherine
• Velly Lionel
• Brochier Thomas

Classifications

• A61M16/12 Primary

  by mixing different gases · CPC title

• A61B17/22

  Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for · CPC title

• A61K9/0073 Primary

  Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; (nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M) · CPC title

• A61K33/00 Primary

  Medicinal preparations containing inorganic active ingredients · CPC title

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title