Medicament delivery devices

Patent metadata

Field	Value
Publication number	US-11717611-B2
Application number	US-201716462139-A
Country	US
Kind code	B2
Filing date	Nov 17, 2017
Priority date	Nov 18, 2016
Publication date	Aug 8, 2023
Grant date	Aug 8, 2023

Abstract

A medicament delivery device (100) for delivery of medicament from a cartridge (10) into an injection site, through a cannula (134). The cartridge has a medicament chamber (14) with an outlet (15), and a sealing element (16) for closing the outlet (15). The device has a housing (102) for receiving the cartridge (10), and a drive mechanism (200) to expel the medicament from the device upon activation of the drive mechanism (200). The device has a connection arrangement (199) comprising a hub (166) and spring means (184) for driving relative movement between the hub (166) and the cartridge (10) upon operation of an operating member (190). The operating member switches the connection arrangement (199) from an unconnected configuration to a connected configuration, in which the hub (166) cooperates with the cartridge (10) to open the outlet (15). When connected, fluid may flow between the chamber (14) and the cannula (134).

First claim

The invention claimed is:

1. A medicament delivery device for delivery of medicament from a cartridge into an injection site through a cannula, the cartridge comprising a first chamber having an outlet, and a sealing element for closing the outlet, the device comprising: a housing for receiving the cartridge; a drive mechanism comprising a drive element that is moveable with respect to the housing in a forward direction along a drive axis to expel the medicament from the device upon activation of the drive mechanism; and a connection arrangement comprising a hub and a spring for driving relative movement between the hub and the cartridge upon operation of an operating member of the device so as to switch the connection arrangement from an unconnected configuration in which the outlet is closed to a connected configuration in which the hub cooperates with the cartridge to open the outlet, thereby to establish a connection for fluid flow between the first chamber and the cannula, wherein the operating member comprises a shield for shielding the cannula, wherein the shield is moveable to expose the cannula, and wherein movement of the shield to expose the cannula releases the hub to move axially along a longitudinal axis of the medicament delivery device into the connected configuration.

2. The delivery device according to claim 1 , further comprising a contact face for contact with the injection site for delivery of the medicament, wherein the drive axis is substantially parallel to the contact face.

3. The delivery device according to claim 1 , wherein the spring comprises a compression spring.

4. The delivery device according to claim 1 , further comprising a control mechanism for holding the connection arrangement in the unconnected configuration and for allowing relative movement between the cartridge and the hub upon operation of the operating member to switch the connection arrangement to the connected configuration.

5. The delivery device according to claim 1 , wherein the shield is removable from the housing to expose the cannula.

6. The delivery device according to claim 1 , the cannula comprising a hypodermic needle.

7. The delivery device according to claim 1 , the device further comprising the cartridge.

8. A medicament disposed in the delivery device according to claim 1 .

9. The delivery device according to claim 1 , wherein the cartridge is moveable with respect to the housing to switch the connection arrangement from the unconnected configuration to the connected configuration.

10. The delivery device according to claim 9 , wherein the spring biases the cartridge in the forward direction along the drive axis.

11. The delivery device according to claim 1 , wherein the drive element is biased for movement in the forward direction.

12. The delivery device according to claim 11 , further comprising a drive spring for biasing the drive element in the forward direction.

13. The delivery device according to claim 1 , wherein the hub is moveable with respect to the housing.

14. The delivery device according to claim 13 , wherein the hub is moveable with respect to the housing to switch the connection arrangement from the unconnected configuration to the connected configuration.

15. The delivery device according to claim 13 , wherein the spring biases the hub in a rearward direction along the drive axis.

16. The delivery device according to claim 1 , wherein the drive mechanism comprises a drive member that is rotatable with respect to the housing and a driver for driving rotation of the drive member.

17. The delivery device according to claim 16 , wherein the driver comprises a power spring.

18. The delivery device according to claim 16 , further comprising a transmission member for transferring force from the drive member to the drive element.

19. The delivery device according to claim 18 , wherein the transmission member comprises a flexible chain.

20. The delivery device according to claim 1 , further comprising a control piece for controlling relative movement between the hub and the housing.

21. The delivery device according to claim 20 , wherein the control piece is coupled to the hub for joint movement with respect to the housing.

22. The delivery device according to claim 20 , wherein the control piece is releasable for movement with respect to the housing upon operation of the operating member.

23. The delivery device according to claim 22 , wherein the spring acts to bias the control piece for movement with respect to the housing.

24. The delivery device according to claim 20 , further comprising a blocking formation for preventing movement of the control piece with respect to the housing, and wherein operation of the operating member causes disengagement of the blocking formation from the control piece to allow movement of the control piece with respect to the housing.

25. The delivery device according to claim 24 , wherein the blocking formation is associated with the operating member.

26. The delivery device according to claim 24 , further comprising:
a cannula holder that is moveable in an insertion direction with respect to the housing for extending the cannula into the injection site;
wherein the blocking formation is associated with the cannula holder; and
wherein movement of the cannula holder in the insertion direction causes disengagement of the blocking formation from the control piece.

27. The delivery device according to claim 1 , wherein the hub is arranged for engagement with a coupling element disposed at an outlet end of the cartridge.

28. The delivery device according to claim 27 , wherein the hub is engageable with the coupling element in a first attachment position in the unconnected configuration of the connection arrangement and in a second attachment position in the connected configuration of the connection arrangement.

29. The delivery device according to claim 27 , wherein the hub comprises at least one clip for engagement with one or more respective engagement formations of the coupling element.

30. The delivery device according to claim 27 , wherein the hub comprises a sealing element release member for cooperation with the sealing element of the cartridge to open the outlet when the connection arrangement is switched to the connected configuration.

31. The delivery device according to claim 30 , wherein the sealing element release member comprises a piercing member for piercing the sealing element.

32. The delivery device according to claim 30 , comprising a seal arrangement for forming a seal with the coupling element to enclose a tip of the sealing element release member in an enclosed chamber when the connection arrangement is in the unconnected configuration.

33. The delivery device according to claim 32 , wherein the enclosed chamber is disposed on a forward side of the sealing element.

34. The delivery device according to claim 1 , further comprising a trigger component that is moveable with respect to the housing to activate the drive mechanism.

35. The delivery device according to claim 34 , wherein the trigger component comprises the operating member.

36. The delivery device according to claim 34 , wherein the trigger component is moveable from a first po

Assignees

• Owen Mumford Ltd

Inventors

• Cowe Toby
• Webb Colin

Classifications

• A61M5/2066 Primary

  comprising means for injection of two or more media, e.g. by mixing · CPC title

• A61M5/2033 Primary

  Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287) · CPC title

• A61M5/2429

  by telescoping of ampoules or carpules with the syringe body · CPC title

• A61M5/3158

  performed by axially moving actuator operated by user, e.g. an injection button · CPC title

• A61M5/31596

  comprising means for injection of two or more media, e.g. by mixing · CPC title