Medical implants and other articles of manufacture based on trabecular bone lattices

Patent metadata

Field	Value
Publication number	US-11717418-B2
Application number	US-201917040453-A
Country	US
Kind code	B2
Filing date	Mar 26, 2019
Priority date	Mar 26, 2018
Publication date	Aug 8, 2023
Grant date	Aug 8, 2023

Abstract

Novel articles of manufacture based comprising lattices based on trabecular bone, having a plurality of plates and interconnecting rods. The trabecular bone-inspired lattice may be designed based on the general alignment of plates and rods found in trabecular bone, including anisotropic lattices having one or more predominant axes of mechanical strength. Lumbar fusion implants and other implants are provided having a trabecular bone inspired lattice in which bone graft material may be packed and providing a scaffold for bone fusion and growth. The implants may be based on bone structures having a predominant axis of mechanical strength and may be deployed in sites with the predominant axis of mechanical strength aligned with the primary axis of mechanical stress, such as in the the spine.

First claim

What is claimed is:

1. An article of manufacture comprising a trabecular bone-inspired lattice, the trabecular bone-inspired lattice comprising
a plurality of plates, wherein each plate comprises a ribbon structure comprising a length, width and thickness and having a predominant axis, wherein over 40% of the plates are anisotropically arranged such that the predominant axis of each plate is in alignment with a predominant axis of mechanical strength of the trabecular bone-inspired lattice; and
a plurality of rods, wherein each rod comprises an elongated structure and wherein the plurality of rods interconnects the plates with one another.

2. The trabecular bone-inspired lattice of claim 1 , wherein
the width of each plate is between 2 and 50 times its thickness; and
the length of each plate is between 2 and 100 times the width of the plate.

3. The trabecular bone-inspired lattice of claim 1 , wherein each plate comprises an elongated rectangle.

4. The trabecular bone-inspired lattice of claim 1 , wherein each plate comprises an elongated, irregular structure.

5. The trabecular bone-inspired lattice of claim 1 , wherein the plates comprise a ribbed, concave, or convex surface.

6. The trabecular bone-inspired lattice of claim 1 , wherein each plate is twisted or helical.

7. The trabecular bone-inspired lattice of claim 1 , wherein the rods are flat, square, circular, or irregular.

8. The trabecular bone-inspired lattice of claim 1 , wherein 40% to 90% of the plates align anisotropically along the predominant axis of mechanical strength of the lattice.

9. The trabecular bone-inspired lattice of claim 1 , wherein different subsets of the plates align along two or more predominant axes of the lattice.

10. The trabecular bone-inspired lattice of claim 1 , wherein the trabecular bone-inspired lattice is surrounded by a cage comprising a shell or lattice.

11. The trabecular bone-inspired lattice of claim 1 , wherein the lattice comprises one or more localized volumes of an increased measure of mechanical strength, relative to an average mechanical strength measured over a volume of the trabecular bone-inspired lattice.

12. The trabecular bone-inspired lattice of claim 11 , wherein the one or more localized volumes of an increased measure of mechanical strength comprises one or more features selected from an increased width and/or thickness of plates, increased density of rods, increased width, thickness, and/or diameter of rods, and increased alignment of plates.

13. The trabecular bone-inspired lattice of claim 1 , wherein the lattice has a structural model index between 0.5 and 3.5.

14. The trabecular bone-inspired lattice of claim 1 , wherein the lattice has an ellipsoid factor is between −0.5 and 0.5.

15. The trabecular bone-inspired lattice of claim 1 , wherein the lattice has a degree of anisotropy between 0.5 and 3.0.

16. The trabecular bone-inspired lattice of claim 1 , wherein the lattice comprises a replica of a trabecular bone structure.

17. The trabecular bone-inspired lattice of claim 16 , wherein a source bone on which the replica is based comprises bone having a predominant axis of mechanical stress.

18. The trabecular bone-inspired lattice of claim 1 , wherein the lattice is made by additive manufacturing.

19. The trabecular bone-inspired lattice of claim 1 , wherein the lattice comprises a material selected from stainless steel, titanium, aluminum, copper, cobalt chrome, PEEK, ultrahigh molecular weight polyethelene, polyphenylsulfones, polyetheramide materials, polylactic acid, nylons, polymeric material coated with metal, and woven carbon fiber reinforced plastics.

20. The trabecular bone-inspired lattice of claim 1 , further comprising a groove or channel.

21. The trabecular bone-inspired lattice of claim 1 , further comprising a window to allow imaging of bone graft material.

22. The trabecular bone-inspired lattice of claim 1 , further comprising bone graft material, wherein the bone graft material is contained in hollow spaces within the trabecular bone-inspired lattice.

23. The trabecular bone-inspired lattice of claim 22 , wherein the bone graft material comprises autologous bone tissue, bone marrow aspirate, or demineralized bone matrix.

24. The trabecular bone-inspired lattice of claim 22 , wherein the bone graft material further comprises bone morphogenic protein.

Assignees

• Univ California
• Li Alfred

Inventors

• Dang Alan
• Dang Alexis
• Chang Wenhan
• Li Alfred

Classifications

• A61F2/447 Primary

  substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section · CPC title

• A61F2/3094

  Designing or manufacturing processes · CPC title

• A61F2002/3092

  having an open-celled or open-pored structure · CPC title

• A61F2002/3093

  for promoting ingrowth of bone tissue · CPC title

• A61F2002/30593

  hollow · CPC title