Detection apparatus for determining a state of tissue

Patent metadata

Field	Value
Publication number	US-11717165-B2
Application number	US-201214356180-A
Country	US
Kind code	B2
Filing date	Oct 30, 2012
Priority date	Nov 7, 2011
Publication date	Aug 8, 2023
Grant date	Aug 8, 2023

Abstract

The invention relates to a detection apparatus (30) for determining a state of tissue. The detection apparatus (30) comprises a fluorescence spectrum providing unit (2, 3) for providing a fluorescence spectrum of the tissue, a differentiation unit (4) for generating a derivative of the fluorescence spectrum, and a tissue state determination unit (5) for determining the state of the tissue from the derivative. This allows determining the state of the tissue, even if characteristics, which are related to the state of the tissue, are only hardly visible or not visible at all in the fluorescence spectrum. The reliability of determining the state of the tissue, for instance, whether the tissue is cancerous or not, can therefore be improved.

First claim

The invention claimed is:

1. A detection system for detecting a state of tissue, comprising:
an excitation light source configured to generate excitation light for exciting the tissue;
at least one fiber configured to guide the excitation light from the excitation light source to the tissue;
an emission light detector configured to generate a fluorescence spectrum from emission light emitted by the tissue in response to excitation by the excitation light; and
at least one processor configured to:
define a first tissue state related to a first wavelength within a first wavelength range and a second tissue state related to a second wavelength in a second wavelength range,
generate a derivative of the fluorescence spectrum,
determine a first measure based on at least one of i) a first difference between a) the derivative at a wavelength which is smaller than the first wavelength and within the first wavelength range and b) the derivative at a wavelength which is larger than the first wavelength and within the first wavelength range, and ii) a second difference between a) the derivative at a wavelength which is smaller than the second wavelength and within the second wavelength range and b) the derivative at a wavelength which is larger than the second wavelength and within the second wavelength range, and
determine whether the tissue is in the first tissue state or the second tissue state based on the determined first measure.

2. The detection system of claim 1 , wherein the first tissue state and the second tissue state are related to a wavelength in a wavelength range of 600 to 700 nm.

3. The detection system of claim 1 ,
wherein the first wavelength range is 630 to 640 nm and the second wavelength range is 620 to 630 nm.

4. The detection system of claim 1 ,
wherein at least one of the first tissue state and the second tissue state is related to a further wavelength, and
wherein the at least one processor is further configured to determine whether the tissue is in the first tissue state or the second tissue state based on the first measure and a further measure that depends on the fluorescence spectrum of the tissue at a further wavelength within a further wavelength range.

5. The detection system of claim 4 ,
wherein the at least one processor is further configured to determine the further measure based on a difference between:
a) the derivative at a wavelength which is smaller than the respective further wavelength and within the respective further wavelength range, and
b) the derivative at a wavelength which is larger than the respective further wavelength and within the respective further wavelength range.

6. The detection system of claim 4 ,
wherein the further wavelength is within a range of 675 to 685 nm or within a range of 685 to 695 nm.

7. The detection system of claim 1 ,
wherein the at least one processor is further configured to provide a tissue type of the tissue and provide at least one of several predefined first measures depending on the provided tissue type.

8. The detection system of claim 7 ,
wherein the excitation light source is configured to illuminate the tissue with tissue type detection light; and
the emission light detector is configured to detect the tissue type based on the tissue type detection light.

9. The detection system of claim 1 , wherein the tissue state is determined based on raw measurement data of the fluorescence spectrum of the tissue generated based on the emission light emitted by the tissue in response to excitation by the excitation light.

10. The detection system of claim 1 , wherein the tissue state is determined without calculating an intrinsic fluorescence spectrum.

11. The detection system of claim 1 , wherein the first tissue state corresponds to healthy tissue and wherein the second tissue state corresponds to cancerous tissue.

12. The detection system of claim 11 , further comprising an ablation energy source configured to apply ablation energy to the tissue if the tissue has been determined to be cancerous tissue.

13. The detection system of claim 1 , wherein the first tissue state is defined to correspond to a first measure being greater than or equal to a predetermined threshold value, and wherein the second tissue state is defined to correspond to the first measure being less than the predetermined threshold value.

Assignees

• Koninklijke Philips Nv

Inventors

• Mueller Manfred
• Hendriks Bernardus Hendrikus Wilhelmus
• Lucassen Gerhardus Wilhelmus
• Horikx Jeroen Jan

Classifications

• A61B5/0071 Primary

  by measuring fluorescence emission · CPC title

• A61B18/1492

  having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence) · CPC title

• A61B2018/00577

  Ablation · CPC title

• A61B2018/00642

  with feedback, i.e. closed loop control · CPC title