Method, apparatus, system and computer program product for selecting a filter for a filtration process

Patent metadata

Field	Value
Publication number	US-11714935-B2
Application number	US-201816955879-A
Country	US
Kind code	B2
Filing date	Dec 17, 2018
Priority date	Dec 22, 2017
Publication date	Aug 1, 2023
Grant date	Aug 1, 2023

Abstract

Methods for selecting a filter for a filtration process are described. Input data is received, and based on the input data, one or more filter characteristics for each of a plurality of filter candidates for a filtration process are identified. Process parameters of the filtration process are identified. A computer-implemented simulation process of the filtration process for each of the plurality of filter candidates is performed, based on the identified process parameters and identified filter characteristics. One or more output characteristics of the filtration process are determined based on the simulation. A filter candidate of the plurality of filter candidates is selected based on the one or more output characteristics.

First claim

The invention claimed is:

1. A method for selecting a filter for a filtration process, comprising:
receiving input data, and based thereon identifying one or more filter characteristics for each of a plurality of filter candidates for a filtration process;
identifying process parameters of the filtration process;
performing a computer-implemented simulation process of the filtration process for each of the plurality of filter candidates, based on the identified process parameters and identified filter characteristics by using:
a first simulation stage, comprising determining one or more static process parameters of the filtration process, wherein the one or more static process parameters are determined on the basis of an iterative algorithm; and
a second simulation stage, comprising determining one or more dynamic characteristics of the filtration process, based on the determined one or more static process parameters;

determining one or more output characteristics of the filtration process based on the simulation; and
selecting a filter candidate of the plurality of filter candidates based on the one or more output characteristics.

2. The method according to claim 1 , wherein the input data comprises a plurality of respective filter identifiers of the filter candidates, and the method comprises retrieving data from a data store storing associations between filter identifiers and corresponding filter characteristics, thereby identifying the filter characteristics for the plurality of filter candidates.

3. The method according to claim 1 , wherein the one or more static process parameters are determined at least partly on the basis of an iterative algorithm.

4. The method according to claim 1 , wherein the one or more output characteristics are derived from the determined one or more dynamic characteristics.

5. The method according to claim 1 , wherein the selection of the filter candidate is based on a comparison of the determined one or more output characteristics with desired output characteristics.

6. The method according to claim 1 , comprising providing an indication of the selected filter candidate.

7. The method according to claim 1 , comprising performing one or more further iterations of the computer-implemented simulation process using one or more filter characteristics of the selected filter, including varying process parameters of the filtration process between different iterations, and comparing output characteristics from the different iterations.

8. The method according to claim 7 , comprising comparing the output characteristics from the different iterations with desired output characteristics and, based thereon, selecting a set of parameters for the filtration process.

9. The method according to claim 1 , wherein the one or more filter characteristics include a geometric characteristics and/or a porosity characteristic.

10. The method according to claim 1 , wherein the filtration process parameters include one or more parameters relating to a feed fluid of the filtration process, including one or more of: an initial volume, an initial concentration, a temperature, a solubility and a viscosity.

11. The method according to claim 1 , wherein the one or more output characteristics comprises one or more of a product volume, a product composition and a product viscosity.

12. The method according to claim 1 , wherein the simulation process comprises a simulation of a solidified solute layer on the filter.

13. The method according to claim 1 , wherein the filtration process comprises a cross-flow filtration process.

14. The method according to claim 1 , comprising:
receiving measurement data from a filtration system executing a filtration process corresponding to the simulated filtration process.

15. The method according to claim 14 , comprising:
modifying the simulation based on the measurement data.

16. The method according to claim 14 , comprising:
comparing the measurement data with data from the simulated filtration process; and
determining whether there is a difference in the filtration process and the simulated filtration process based on the comparison of the measurement data with data from the simulated filtration process, wherein the difference indicates an abnormality in the filtration process.

17. A computer program product configured to execute the method of claim 1 .

18. An apparatus comprising at least one processor configured to perform the method of claim 1 .

Assignees

• Global Life Sciences Solutions Usa Llc

Inventors

• Ramakrishna Manoj Kumar
• Puranik Swapnil
• Khan Mohammed Mehtab

Classifications

• G06F30/20 Primary

  Design optimisation, verification or simulation (optimisation, verification or simulation of circuit designs G06F30/30) · CPC title

• B01D63/084

  at least one flow duct intersecting the membranes · CPC title

• G06F30/23 Primary

  using finite element methods [FEM] or finite difference methods [FDM] · CPC title