Conscious animal ultrasonic neural regulation device

Patent metadata

Field	Value
Publication number	US-11707635-B2
Application number	US-201716492405-A
Country	US
Kind code	B2
Filing date	Apr 21, 2017
Priority date	Mar 9, 2017
Publication date	Jul 25, 2023
Grant date	Jul 25, 2023

Abstract

Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.

First claim

What is claimed is:

1. A conscious animal ultrasonic neural regulation device, comprising a pulse signal generation component, an ultrasonic transducer component and a fixing component;
wherein the pulse signal generation component is configured to generate a pulse signal;
the ultrasonic transducer component is configured to convert the pulse signal into an ultrasound;
the fixing component comprises an upper fixing component and a lower fixing component;
wherein the upper fixing component is configured to fix the ultrasonic transducer component, and the lower fixing component is configured to be fixed on an animal neural regulation target point;
the upper fixing component and the lower fixing component are connected by a connecting component,
wherein the pulse signal generation component comprises:
an independent two-channel signal generator, configured to generate a pulse waveform for neural regulation;
a power amplifier, configured to increase an energy of the regulation pulse waveform; and
an impedance matching circuit, configured to perform personalization design based on an actual measured impedance value of a piezoelectric array element, to realize impedance matching;
wherein the two-channel signal generator comprises a first channel and a second channel, the first channel is configured to control a pulse repetition frequency, a number of pulses, and a pulse period, the second channel is configured to control a fundamental frequency, a number of fundamentals and an output voltage, a trigging manner of the second channel is external trigging via Transistor-Transistor Logic (TTL) signal of the second channel; and
wherein the ultrasonic transducer component comprises a leading wire, the piezoelectric array element and a backing;
the piezoelectric array element is connected to the leading wire, and the leading wire is connected to the impedance matching circuit of the pulse signal generation component;
the backing is made of an epoxy resin material, and provided with a water inlet and an air outlet, the water inlet and the air outlet are configured to inject deionized water into the backing;
wherein the piezoelectric array element is composed of a single array element, the single array element has an arc shaped structure capable of reaching a neutral regulation depth, and the piezoelectric array element is configured to focus the ultrasound generated by the piezoelectric array element on an animal brain target region through the deionized water injected into the backing.

2. The device according to claim 1 , wherein the pulse signal generation component further comprises an oscilloscope connected with the independent two-channel signal generator and configured to observe an output waveform.

3. The device according to claim 1 , wherein the two-channel signal generator has a fundamental frequency at least in a range of 0.1 MHz to 5 MHz, is configured to independently generate a sinusoidal signal and a square wave signal, and has a TTL gate trigger output function.

4. The device according to claim 1 , wherein the power amplifier has a frequency band in a range of 0.1 MHz to 5 MHz, and a power range of 50 W to 150 W.

5. The device according to claim 1 , wherein a piezoelectric material of the piezoelectric array element comprises at least one of a piezoelectric ceramic, a composite piezoelectric material, and a crystalline material.

6. The device according to claim 1 , wherein the fixing component is a ring shaped structure.

7. The device according to claim 1 , wherein the fixing component is made of an organic glass material or a plastic.

Assignees

• Shenzhen Inst Of Adv Tech Cas

Inventors

• Zheng Hairong
• Zhou Hui
• Niu Lili
• Guo Ruibiao
• Meng Long
• Li Yongchuan
• Su Min
• Huang Jiqing
• Qian Ming

Classifications

• A61N7/00 Primary

  Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) · CPC title

• B06B1/0215

  for generating pulses, e.g. bursts of oscillations, envelopes · CPC title

• B06B1/067

  which is used as, or combined with, an impedance matching layer · CPC title

• A01K29/005

  Monitoring or measuring activity · CPC title

• A61N2007/0026

  Stimulation of nerve tissue · CPC title