Method for coating microstructured components

Patent metadata

Field	Value
Publication number	US-11701478-B2
Application number	US-201615765889-A
Country	US
Kind code	B2
Filing date	Oct 6, 2016
Priority date	Oct 9, 2015
Publication date	Jul 18, 2023
Grant date	Jul 18, 2023

Abstract

The present disclosure provides a method for the surface modification of microstructured components having a polar surface, in particular for high-pressure applications. According to the method, a microstructured component is contacted, in particular treated, with a modification reagent, wherein the surface properties of the component are modified by chemical and/or physical interaction of the component surface and of the modification reagent.

First claim

The invention claimed is:

1. A discharge apparatus for fluids comprising a microstructured component comprising a surface modification obtained by contacting the surface of the microstructured component with a modification reagent, thereby modifying the properties of the surface by the chemical and/or physical interaction between the microstructured component surface and the modification reagent;
wherein the modification reagent comprises at least one modifier, wherein the modifier is a silane of the general formula (III):
R 4-n SiX n

wherein
R is C 10 -C 16 alkyl,
X is selected from C 1 alkoxy and C 2 alkoxy, and
n is 3; and
wherein the at least one modifier is at a concentration of from 0.001 to 2 mol/L based on the modification reagent.

2. The discharge apparatus according to claim 1 , comprising at least one liquid medicinal product.

3. The discharge apparatus according to claim 2 , wherein the liquid medicinal product is a dispersion or solution of at least one pharmaceutical active ingredient.

4. A microstructured component for use in a microfluidic system, comprising an outer surface, at least one inlet opening, at least one outlet opening, and inner surfaces formed by microstructures, wherein the inner surfaces are modified, at least in part, with a silane modifier of general formula (III):
R 4-n SiX n

wherein
R is C 10 -C 16 alkyl,
X is selected from C 1 alkoxy and C 2 alkoxy, and
n is 3.

5. The microstructured component according to claim 4 , wherein the outer surface of the component is modified.

6. The microstructured component according to claim 4 , wherein the inner surface of the component is modified to be rendered hydrophobic.

7. A microstructured component according to claim 4 , wherein the silane is selected from the group consisting of C 12 alkyltrialkoxysilanes, C 14 alkyltrialkoxysilanes and C 16 alkyltrialkoxysilanes, and mixtures thereof.

8. The microstructured component according to claim 4 , wherein the inner surface of the microstructured component is activated before modification.

9. The microstructured component according to claim 4 , wherein the microstructured component comprises two outlet openings and the microstructured component has channels which connect the outlet openings directly or indirectly with the at least one inlet opening.

10. The microstructured component according to claim 9 , wherein the channels of the outlet openings are oriented towards one another at an angle of from 50° to 130°.

11. The microstructured component according to claim 4 , wherein the microstructured component further comprises a filter region between the inlet opening and the outlet opening.

12. The microstructured component according to claim 4 , wherein the component consists of two different materials.

13. The microstructured component according to claim 12 , wherein the component consists of glass and silicon wherein the inner surfaces of the component are modified, at least in part, with a silane modifier of general formula (III).

14. The microstructured component according to claim 12 , wherein at least one of the materials is microstructured on a side on which the material is bonded to a second material and thus there is a microstructure located within the component as a result of the bonding between the different materials.

Assignees

• Boehringer Ingelheim Int

Inventors

• Frache Daniel

Classifications

• B05B1/26

  with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets · CPC title

• A61M11/006 Primary

  operated by applying mechanical pressure to the liquid to be sprayed or atomised · CPC title

• A61M15/009

  using medicine packages with incorporated spraying means, e.g. aerosol cans (pocket atomiser of the injector type A61M11/08) · CPC title

• A61M15/0065 Primary

  Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52) · CPC title

• A61M15/0068

  Indicating or counting the number of dispensed doses or of remaining doses · CPC title