Powder for achieving hemostasis

Patent metadata

Field	Value
Publication number	US-11701448-B2
Application number	US-202017002399-A
Country	US
Kind code	B2
Filing date	Aug 25, 2020
Priority date	Jan 12, 2018
Publication date	Jul 18, 2023
Grant date	Jul 18, 2023

Abstract

In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site. In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.

First claim

The invention claimed is:

1. A method of treating a tissue site comprising:
administering a composition to the tissue site;
wherein the composition includes a powder that comprises first particles comprising chitosan or a chitosan salt and second particles that comprise a crosslinking agent, wherein the crosslinking agent is a derivatized polymer selected from an epoxy derivatized polymer, an acrylate derivatized polymer, or a genipin derivatized polymer.

2. The method of claim 1 , wherein the composition is applied via a catheter.

3. The method of claim 1 , wherein the composition is fluidized in a gas to form a fluidized powder and blown onto the tissue site.

4. The method of claim 3 , wherein the gas is CO 2 .

5. The method of claim 3 , wherein the fluidized powder is applied using a catheter and wherein the fluidized powder exits the catheter at a velocity ranging from 15 m/s to 50 m/s.

6. A composition comprising:
first particles comprising chitosan or a chitosan salt; and
second particles comprising a crosslinking agent, wherein the crosslinking agent is selected from an epoxy derivatized polymer, an acrylate derivatized polymer, a genipin derivatized polymer, a multifunctional epoxy, acrylate, or genipin.

7. The composition of claim 6 , wherein the crosslinking agent is the epoxy derivatized polymer or the acrylate derivatized polymer.

8. The composition of claim 6 , wherein the first particles comprise a chitosan salt, wherein the chitosan salt comprisesa chitosan halide, a chitosan salt of an organic mono-acid, or a chitosan salt of an organic diacid.

9. The composition of claim 6 , wherein the epoxy derivatized polymer is epoxy derivatized chitosan, the acrylate derivatized polymer is acrylate derivatized chitosan, and the genipin derivatized polymer is genipin derivatized chitosan.

10. A method of treating or preventing bleeding at a tissue site comprising applying the composition of claim 6 to a gastrointestinal tract through an endoscope.

11. The method of claim 10 , wherein the composition is fluidized in a gas to form a fluidized powder composition and blown onto the tissue site.

12. The method of claim 11 , wherein the gas is CO 2 .

13. The method of claim 11 , wherein the fluidized powder exits the endoscope at a velocity ranging from 15 m/s to 50 m/s.

14. A composition comprising:
first particles comprising a modified chitosan selected from an aldehyde modified chitosan, epoxy modified chitosan, chitosan modified with unsaturated groups, chitosan derivatized with a multifunctional epoxide, acrylate modified chitosan, or thiol-modified chitosan; and
second particles comprising a covalent crosslinking agent;
wherein the composition is in the form of a powder; and
wherein the covalent crosslinking agent is a molecule having a plurality of unsaturated groups when the first particles comprise thiol-modified chitosan.

15. The composition of claim 14 , wherein the molecule having a plurality of unsaturated groups comprises a hydrophilic polymer having unsaturated end groups.

16. The composition of claim 14 , wherein the covalent crosslinking agent is a hydrophilic polymer having terminal carboxylic acid groups or terminal amine groups when the first particles comprise aldehyde modified chitosan, epoxy modified chitosan, chitosan modified with unsaturated groups, chitosan derivatized with a multifunctional epoxide, acrylate modified chitosan; and
wherein the covalent crosslinking agent is a molecule including an acrylate-terminated hydrophilic polymer when the first particles comprise thiol-modified chitosan.

17. A method of treating or preventing bleeding at a tissue site comprising applying the composition of claim 14 to a gastrointestinal tract through an endoscope.

18. The method of claim 17 , wherein the composition is fluidized in a gas to form a fluidized powder and blown onto the tissue site.

19. The method of claim 18 , wherein the gas is CO 2 .

20. The method of claim 18 , wherein the fluidized powder exits the endoscope at a velocity ranging from 15 m/s to 50 m/s.

Assignees

• Boston Scient Scimed Inc

Inventors

• Fredrickson Gerald
• Smith Amanda L
• Pic Andrew
• Gervasio Sophia
• Lydecker Lauren

Classifications

• A61L26/0023 Primary

  Polysaccharides · CPC title

• A61K31/722

  Chitin, chitosan · CPC title

• A61L26/008

  Hydrogels or hydrocolloids · CPC title

• A61L26/0066

  Medicaments; Biocides · CPC title

• A61L31/042

  Polysaccharides · CPC title