Substituted bicyclic compounds

Patent metadata

Field	Value
Publication number	US-11701373-B2
Application number	US-202117307138-A
Country	US
Kind code	B2
Filing date	May 4, 2021
Priority date	Aug 20, 2014
Publication date	Jul 18, 2023
Grant date	Jul 18, 2023

Abstract

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):

and/or a salt thereof, wherein R 1 is —OH or —OP(O)(OH) 2 , and X 1 , X 2 , X 3 , R 2 , R 2a , R a , R b , and R c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P 1 , and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

First claim

What is claimed is:

1. A compound of Formula (IV):

or a salt thereof, wherein:
R 1 is —OH or —OP(O)(OH) 2 ;
R 2a is —C(O)(CH 2 ) 0-4 C(R x ) 3 ;
each R x is independently H;
and
each R b is independently H.

2. The compound according to claim 1 having the structure of Formula (IVc):

or a salt thereof.

3. The compound according to claim 1 or a salt thereof.

4. The compound according to claim 1 , wherein said compound is:

5. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier, wherein R 1 is —OH.

Assignees

• Bristol Myers Squibb Co

Inventors

• Dyckman Alaric J
• Dhar T G Murali
• Xiao Hai-Yun
• Gilmore John L
• Yang Michael G
• Xiao Zili
• Marcoux David

Classifications

• A61K31/695 Primary

  Silicon compounds · CPC title

• A61K31/135

  having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)} · CPC title

• A61K31/137 Primary

  Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title

• A61K31/15

  Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) {; Imines (C—N=C)} · CPC title

• A61K31/165

  having aromatic rings, e.g. colchicine, atenolol, progabide · CPC title