Treatment method for colon cancer

Patent metadata

Field	Value
Publication number	US-11701329-B2
Application number	US-202217956887-A
Country	US
Kind code	B2
Filing date	Sep 30, 2022
Priority date	May 3, 2019
Publication date	Jul 18, 2023
Grant date	Jul 18, 2023

Abstract

The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe 3 O 4 , as well as compositions containing HSS.

First claim

The invention claimed is:

1. A treatment method for colon cancer, comprising:
administering to a subject in need of treatment for colon cancer an aqueous composition comprising Fe 3 O 4 -hollow silica spheres (“Fe-HSS”),
wherein the aqueous composition is administered in an amount sufficient to induce nuclear condensation, augmentation, and disintegration of cells of the cancer,
wherein the Fe-HSS are calcined,
wherein the surfaces of the Fe-HSS comprise no more than 0.05 mol. % phenyl or aryl groups, relative to an average uncalcined Fe-HSS,
wherein Fe-HSS have a hollow core space containing plural individual particles of Fe 3 O 4 having an average diameter in a range of from 9.5 nm to 21.3 nm and the Fe 3 O 4 has a polycrystalline spinel structure,
wherein the hollow silica spheres of the Fe 3 O 4 -hollow silica spheres have a core-shell structure with shells larger in thickness than cores, and the hollow silica spheres have an average diameter in a range of from 415 to 615 nm,
wherein the Fe-HSS have an average shell thickness in a range of from 150 to 210 nm, and
wherein the particles of Fe 3 O 4 are present a range of from 0.1 to 10 wt % of a combined weight of the HSS and Fe 3 O 4 in the Fe-HSS.

2. The method of claim 1 , wherein the hollow silica spheres are prepared by a process comprising hydrolysis of a mixture comprising Fe 3 O 4 and phenyl-tri-methoxysilane or another hydrolyzable aryl silane followed by condensation with a hydroxide base.

3. The method of claim 1 , wherein the surfaces of the Fe-HSS are free of phenyl or aryl groups.

4. The method of claim 1 , wherein the Fe-HSS further comprise at least one anticancer drug or agent.

5. The method of claim 1 , wherein the aqueous composition comprising the HSS is administered in situ to the site of a tumor or a tissue or organ containing cancer cells.

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Bozkurt Ayhan
• Anil Seyda Tugba Gunday
• Khan Firdos Alam
• Akhtar Sultan

Classifications

• A61K9/16 Primary

  Agglomerates; Granulates; Microbeadlets {; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction (A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51)} · CPC title

• A61K9/1682

  Processes · CPC title

• A61K33/00

  Medicinal preparations containing inorganic active ingredients · CPC title

• A61K33/26

  Iron; Compounds thereof · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title