Synchronization of ion generation with cycling of a discontinuous atmospheric interface

Patent metadata

Field	Value
Publication number	US-11699580-B2
Application number	US-202016930388-A
Country	US
Kind code	B2
Filing date	Jul 16, 2020
Priority date	Jan 20, 2011
Publication date	Jul 11, 2023
Grant date	Jul 11, 2023

Abstract

The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

First claim

What is claimed is:

1. An online reaction monitoring system, the system comprising:
a mass spectrometer;
a reaction vessel that is pressurized with an inert gas and comprises an outlet port;
a channel that extends from within the outlet port; and
an electrode operably associated with a distal end of the channel, wherein the electrode is not associated with the mass spectrometer, is external to the channel and does not physically contact the channel or a liquid or vapor within the channel.

2. The system according to claim 1 , wherein the electrode is positioned to inductively interact with a distal end of the channel.

3. The system according to claim 1 , wherein the reaction vessel comprises one or more inlet ports.

4. The system according to claim 3 , wherein the system further comprises a gas source operably coupled to the reaction vessel through one of the one or more inlet ports.

5. The system according to claim 1 , wherein the channel extends into the reaction vessel.

6. The system according to claim 1 , wherein the channel comprises one or more splitters.

7. The system according to claim 6 , wherein a first splitter withdraws a portion of a liquid from the channel.

8. The system according to claim 7 , wherein a second splitter is coupled to a nebulizing gas source in order to introduce a nebulizing gas into the channel.

9. The system according to claim 1 , further comprising a heating element operably associated with the reaction vessel.

10. The system according to claim 1 , wherein the mass spectrometer is a miniature mass spectrometer.

11. An online reaction monitoring system, the system comprising:
a mass spectrometer
a reaction vessel that is pressurized with an inert gas and comprises an outlet port;
a channel that extends from within the outlet port; and
an electrode positioned to inductively interact with a distal end of the channel, the electrode producing a pulsed current, wherein the electrode is not associated with the mass spectrometer, is external to the channel and does not physically contact the channel or a liquid or vapor within the channel.

12. The system according to claim 11 , wherein the pulsed current is a pulsed DC current.

13. The system according to claim 11 , wherein the reaction vessel comprises one or more inlet ports.

14. The system according to claim 13 , wherein the system further comprises a gas source operably coupled to the reaction vessel through one of the one or more inlet ports.

15. The system according to claim 11 , wherein the channel extends into the reaction vessel.

16. The system according to claim 11 , wherein the channel comprises one or more splitters.

17. The system according to claim 16 , wherein a first splitter withdraws a portion of a liquid from the channel.

18. The system according to claim 17 , wherein a second splitter is coupled to a nebulizing gas source in order to introduce a nebulizing gas into the channel.

19. The system according to claim 11 , further comprising a heating element operably associated with the reaction vessel.

20. The system according to claim 11 , wherein the mass spectrometer is a miniature mass spectrometer.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Li Guangtao
• Huang Guangming
• Duncan Jason
• Li Xin
• Sokol Ewa
• Yan Xin

Classifications

• H01J49/04 Primary

  Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components · CPC title

• H01J49/4205

  Device types · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01J49/0445

  with means for introducing as a spray, a jet or an aerosol (electrospray ion sources H01J49/165) · CPC title

• G01N27/62 Primary

  by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode · CPC title