Contour electrocorticography (ECoG) array

Patent metadata

Field	Value
Publication number	US-11696713-B2
Application number	US-202016809778-A
Country	US
Kind code	B2
Filing date	Mar 5, 2020
Priority date	Mar 15, 2019
Publication date	Jul 11, 2023
Grant date	Jul 11, 2023

Abstract

ElectroCorticoGraphy (ECoG) sensors and uses are disclosed. These ECoG arrays, systems, and processes may be operable or configured to: i) simultaneously record neural signals while providing stimulation on specific portions of the cortex using a user-guided stimulator; ii) acquire neural signals over a large cortex area; iii) provide individual or group stimulation while concurrently receiving neural feedback; and/or iv) acquire neural signals at a setting remote from the neural source using wireless or other communication techniques.

First claim

What is claimed is:

1. A real-time neural electrocorticography (ECoG) measurement system comprising:
a flexible two-dimensional substrate, the substrate comprising a plurality of tines with each tine comprising a plurality of sensors,
wherein each tine has an arc of curvature, the arc of curvature being at least nineteen centimeters in length,
wherein the substrate comprises a biocompatible material,
wherein a plurality of open spacings exist between adjacent tines of the plurality of tines;
a wired connector connected to an output of the plurality of sensors; and
a wireless transceiver in communication with the wired connector,
wherein each sensor of the plurality of sensors has a mass of 3.0 mg to 98 mg, and
wherein the transceiver has circuit topology configured to send neural signals received from the sensors to a system monitor.

2. The system of claim 1 wherein circuit topology of the transceiver is configured to provide contemporaneous reporting of neural signals received from the sensors when external stimulation is provided between sensors of the plurality of sensors.

3. The system of claim 1 wherein the system monitor is configured to receive the contemporaneous neural signals from the transceiver and to record the received contemporaneous neural signals.

4. The system of claim 1 further comprising a coating of medical grade silicone with a thickness of no more than 0.8 mm.

5. The system of claim 1 wherein the substrate comprises no more than 0.8 mm of medical grade silicone.

6. The system of claim 1 wherein the flexible two-dimensional substrate is in the shape of a trident.

7. The system of claim 1 wherein the sensors are equidistantly spaced along tines of the substrate.

8. The system of claim 1 wherein the plurality of open spacings further comprises end recesses between the adjacent tines of the plurality of tines.

9. The system of claim 1 wherein at least one cross-member connects the adjacent tines of the plurality of tines.

10. A real-time neural electrocorticography (ECoG) measurement system comprising:
a flexible two-dimensional substrate, the substrate comprising a plurality of arrays with each array comprising a plurality of electrodes,
wherein each array has a radius of curvature, the radius of curvature being at least nineteen centimeters in length,
wherein the substrate comprises a biocompatible material,
wherein a plurality of open spacings exist between adjacent arrays of the plurality of arrays;
a wired connector connected to an output of the plurality of electrodes; and
a wireless transceiver in communication with the wired connector,
wherein each electrode of the plurality of electrodes has a mass of 3.0 mg to 98 mg, and
wherein the transceiver has circuit topology configured to send neural signals received from the electrodes to a system monitor.

11. The system of claim 10 wherein the arrays are one-dimensional arrays.

12. The system of claim 10 wherein circuit topology of the transceiver is configured to provide contemporaneous reporting of neural signals received from the sensors when external stimulation is provided between electrodes of the plurality of electrodes.

13. The system of claim 10 wherein the system monitor is configured to receive the contemporaneous neural signals from the transceiver and to record the received contemporaneous neural signals.

14. The system of claim 10 wherein the substrate comprises no more than 0.8 mm of medical grade silicone.

15. The system of claim 10 wherein the flexible two-dimensional substrate is in the shape of a polygon.

16. The system of claim 10 wherein the sensors are equidistantly spaced along one-dimensional arrays of the substrate.

17. The system of claim 10 wherein the plurality of open spacings further comprises end recesses between the adjacent arrays of the plurality of arrays.

18. The system of claim 10 wherein at least one cross-member connects the adjacent arrays of the plurality of arrays.

Assignees

• Univ Arizona State
• Mayo Found Medical Education & Res

Inventors

• Chae Junseok
• Liu Shiyi
• Quinones-Hinojosa Alfredo
• Vivas-Buitrago Tito

Classifications

• A61B5/37 Primary

  Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG] · CPC title

• A61B5/0031 Primary

  Implanted circuitry · CPC title

• A61B5/6868

  Brain · CPC title

• A61B2562/046

  in a matrix array · CPC title

• A61B5/24 Primary

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title