Biosynthetic Systems Producing Fungal Indole Alkaloids
US-2015044735-A1 · Feb 12, 2015 · US
Halogenation of complex organic compounds
US11692176B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11692176-B2 |
| Application number | US-202117228211-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 12, 2021 |
| Priority date | Jul 18, 2018 |
| Publication date | Jul 4, 2023 |
| Grant date | Jul 4, 2023 |
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- Title
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Abstract
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The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of halogenating a complex organic compound comprising contacting a complex organic compound with a flavin-dependent halogenase (FDH) variant comprising one or two amino acid substitutions compared to the amino acid sequence set forth in SEQ ID NO:2 or SEQ ID NO:4, wherein the FDH variant is capable of catalyzing the halogenation of a complex organic compound and a halogen under conditions suitable for enzyme-catalyzed halogenation of the complex organic compound. 2. The method of claim 1 wherein the complex organic compound is an aromatic heterocyclic organic compound. 3. The method of claim 2 wherein the aromatic heterocyclic organic compound comprises a bicyclo[2.2.2]diazaoctane ring. 4. The method of claim 2 wherein the aromatic heterocyclic organic compound comprises indole. 5. The method of claim 4 wherein the compound is an indole alkaloid. 6. The method of claim 5 wherein the indole alkaloid is a prenylated indole alkaloid. 7. The method of claim 6 wherein the prenylated indole alkaloid is derived from a Malbranchea species. 8. The method of claim 7 wherein the Malbranchea species is Malbranchea aurantiaca or Malbranchea graminicola. 9. The method of claim 6 wherein the prenylated indole alkaloid is premalbrancheamide, malbrancheamide B, isomalbrancheamide B, malbrancheamide C, or isomalbrancheamide C. 10. The method of claim 1 wherein the halogenation step is a chlorination step. 11. The method of claim 1 wherein the halogenation step is a bromination step.
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Classifications
Drugs for disorders of the muscular or neuromuscular system · CPC title
in which the condensed systems contains four or more hetero rings · CPC title
- A61K31/4995Primary
Pyrazines or piperazines forming part of bridged ring systems · CPC title
Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system (alloxazine or isoalloxazine, e.g. riboflavine C12P25/00) · CPC title
- C12N9/0071Primary
acting on paired donors with incorporation of molecular oxygen (1.14) · CPC title
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- What does patent US11692176B2 cover?
- The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.
- Who is the assignee on this patent?
- Univ Michigan Regents, Univ Michigan
- What technology area does this patent fall under?
- Primary CPC classification A61K31/4995. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).