Dose measurement systems and methods

Patent metadata

Field	Value
Publication number	US-11690959-B2
Application number	US-202117481834-A
Country	US
Kind code	B2
Filing date	Sep 22, 2021
Priority date	Jul 15, 2016
Publication date	Jul 4, 2023
Grant date	Jul 4, 2023

Abstract

Embodiments described herein generally relate to devices, systems and methods for measuring a volume or number of doses remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a light guide disposed and configured to reflect electromagnetic radiation toward the container. The dose measurement system also includes a light guide disposed and configured to emit electromagnetic radiation into the light guide. A plurality of sensors are located in the apparatus that are optically coupleable to the light guide and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light guide. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.

First claim

The invention claimed is:

1. A method comprising:
causing a light source to emit electromagnetic radiation into a light guide such that the light guide scatters the received electromagnetic radiation at random angles into a wide radiation pattern and directs the scattered electromagnetic radiation toward the drug container;
detecting a signature of the scattered electromagnetic radiation transmitted through the drug container with a plurality of sensors optically coupleable to the light guide; and
comparing the signature to a plurality of reference signatures to determine a position of an actuator of a drug delivery device.

2. The method of claim 1 , wherein detecting the signature of the scattered electromagnetic radiation transmitted through the drug container includes detecting at least a portion of the scattered electromagnetic radiation with each of the plurality of sensors.

3. The method of claim 2 , wherein data representative of at least the portion of the scattered electromagnetic radiation detected by two or more of the plurality of sensors is compiled into the signature.

4. The method of claim 1 , further comprising:
correcting the signature for background light.

5. The method of claim 1 , wherein the light source is the only light source caused to emit electromagnetic radiation into the light guide.

6. The method of claim 5 , wherein the correction includes comparing the signature with a background signature representative of electromagnetic radiation detected by the plurality of sensors in a dark state of the light source.

7. The method of claim 1 , wherein the scattered portion of the electromagnetic radiation scattered by the light guide is pulsed.

8. The method of claim 1 , wherein the scattered portion of the electromagnetic radiation scattered by the light guide has a select wavelength.

9. The method of claim 1 , further comprising the light guide directing the received electromagnetic through a diffused exit opening that includes a random indicia of refraction, wherein the diffused exit opening is configured to present random critical angles to internal light rays.

10. A system configured to be removably coupleable to a drug delivery device that includes a drug reservoir and an actuator, the system comprising:
a light source disposed and configured to emit electromagnetic radiation;
a light guide disposed and configured to receive at least a portion of the emitted electromagnetic radiation, the light guide configured to scatter the received electromagnetic radiation at random angles into a wide radiation pattern and configured to direct the scattered portions of the electromagnetic radiation toward the drug reservoir;
a plurality of sensors optically coupleable to the light guide, each sensor of the plurality of sensors disposed and configured to detect at least one of the scattered portions of the electromagnetic radiation, the quantity of electromagnetic radiation communicated through the drug reservoir being a signature representative of a position of the actuator of the drug delivery device.

11. The system of claim 10 , wherein data representative of at least the portion of the scattered electromagnetic radiation detected by two or more of the plurality of sensors is compiled into the signature.

12. The system of claim 10 , wherein the measurement system is configured to correct the signature for background light.

13. The system of claim 10 , wherein the measurement system is configured to compare the signature with a background signature representative of electromagnetic radiation detected by the plurality of sensors in a dark state of the light source.

14. The system of claim 10 , wherein the light source is the only light source configured to emit electromagnetic radiation into the light guide.

15. The system of claim 10 , wherein at least one of the scattered portions of the electromagnetic radiation scattered by the light guide is pulsed.

16. The system of claim 10 , wherein at least one of the scattered portions of the electromagnetic radiation scattered by the light guide has a select wavelength.

17. The system of claim 10 , wherein the light guide includes a diffused exit opening including a random indicia of refraction and is configured to present random critical angles to internal light rays.

Assignees

• Bigfoot Biomedical Inc

Inventors

• Sihlanick Kevin
• Whalley Richard
• Legrand Matthew
• White James
• Carothers Jeffrey

Classifications

• A61M5/31541

  Means preventing setting of a dose beyond the amount remaining in the cartridge · CPC title

• A61M2005/3254

  Shielding of proximal needles, e.g. for pen needles · CPC title

• A61M5/16886

  for measuring fluid flow rate, i.e. flowmeters · CPC title

• A61M5/31535 Primary

  Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose · CPC title

• G01F17/00

  Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies (measuring linear dimensions to determine volume G01B) · CPC title