Method and device for determining an information on an equivalent series resistance

Patent metadata

Field	Value
Publication number	US-11680924-B2
Application number	US-202016829788-A
Country	US
Kind code	B2
Filing date	Mar 25, 2020
Priority date	Dec 14, 2017
Publication date	Jun 20, 2023
Grant date	Jun 20, 2023

Abstract

A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.

First claim

What is claimed is:

1. A method for determining an information on an equivalent series resistance, the method comprising the following steps:
generating at least one excitation voltage signal U target and applying the excitation voltage to at least two measurement electrodes in series with a reference resistance R ref ;
measuring a response signal while applying the at least one excitation voltage signal;
determining a signal flank from the response signal and determining an ohmic signal portion U measured from one or both of shape and height of the signal flank; and
determining the information on the equivalent series resistance ESR from the ohmic signal portion according to the relation

E
⁢
S
⁢
R

=

U

measur
⁢
e
⁢
d

*

R

r
⁢
e
⁢
f

U
target

-

U

measur
⁢
e
⁢
d

.

2. The method according to claim 1 , wherein the excitation voltage signal comprises a square wave signal or a sine wave signal.

3. The method according to claim 1 , wherein the excitation voltage signal comprises a non-continuous signal.

4. A method for determining a concentration of at least one analyte in body fluid, wherein the method comprises a method for determining an information on an equivalent series resistance according to claim 1 , wherein the method for determining the information on the equivalent series resistance comprises:
generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes;
measuring a response signal;
determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and
determining the information on the equivalent series resistance from the ohmic signal portion;

wherein the method comprises at least one analyte measurement step, wherein at least one current response is measured and at least one complex impedance information are determined from the current response; and
wherein the method comprises at least one correction step, wherein the complex impedance information is corrected dependent on the information on equivalent series resistance.

5. A method for compensating voltage drop through at least one measurement circuit, wherein the method comprises a method for determining an information on an equivalent series resistance according to claim 1 , wherein the method for determining the information on the equivalent series resistance comprises:
generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes;
measuring a response signal;
determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and
determining at least one information on an equivalent series resistance from the ohmic signal portion,

wherein the method comprises adjusting the excitation voltage signal dependent on the information on the equivalent series resistance.

6. A method for determining a concentration of at least one analyte in body fluid, wherein the method comprises a method for compensating voltage drop through at least one measurement circuit according to claim 5 , wherein the method for compensating comprises the following steps:
generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes;
measuring a response signal;
determining a signal flank from the first current response and determining an ohmic signal portion from one or both of shape and height of the signal flank;
determining at least one information on an equivalent series resistance from the ohmic signal portion; and
adjusting the excitation voltage dependent on the information on the equivalent series resistance,

wherein the method comprises at least one analyte measurement step, wherein the adjusted excitation voltage is applied to the measurement electrodes, and wherein a second current response is measured, wherein at least one complex impedance information is determined from the second current response.

7. The method of claim 3 , wherein the non-continuous signal is a pulse.

8. The method of claim 1 , wherein the excitation voltage is applied while the signal flank is determined.

9. A method for determining a concentration of at least one analyte in body fluid, the method comprising:
a) at least one step for determining an information on an equivalent series resistance comprising:
a1) generating at least one first excitation voltage signal and applying the first excitation voltage to at least two measurement electrodes;
a2) measuring a response signal while applying the at least one first excitation voltage signal;
a3) determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank;
a4) determining at least one information on an equivalent series resistance from the ohmic signal portion;

b) at least one analyte measurement step comprising:
b1) generating at least one second excitation voltage and applying the second excitation voltage to the measurement electrodes;
b2) measuring a second current response;
b3) determining at least one complex impedance information from the second current response; and

c) at least one correction step comprising one or more of:
adjusting the second excitation voltage dependent on the information on the equivalent series resistance;
correcting one or both of the complex impedance information dependent on the information on the equivalent series resistance.

10. The method of claim 9 , wherein the excitation voltage is applied while the at least one information on an equivalent series resistance is determined.

11. An analytical device for determining a concentration of
at least one analyte in body fluid, wherein the analytical device comprises:
at least one signal generator device adapted to generate at least one excitation voltage signal U target ,
wherein the analytical device comprises at least one reference resistance R ref ,
wherein the signal generator device is adapted to apply the excitation voltage signal to at least two measurement electrodes in series with the reference resistance R ref ,
wherein the analytical device comprises at least one measurement unit adapted to receive at least one response signal while the signal generator device applies the at least one excitation v

Assignees

• Roche Diagnostics Operations Inc

Inventors

• Lambertson Michael
• Bauer-Espindola Klaus
• Evgin Samuel
• Horn Carina
• Marquant Michael

Classifications

• G01N27/3273 Primary

  Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875) · CPC title

• G01N33/48

  Biological material, e.g. blood, urine (G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence); Haemocytometers (counting blood corpuscules distributed over a surface by scanning the surface G06M11/02) · CPC title

• G01N27/327 Primary

  Biochemical electrodes {, e.g. electrical or mechanical details for in vitro measurements} · CPC title