Bioprinter and methods of manufacturing an organomimetic device

Patent metadata

Field	Value
Publication number	US-11679546-B2
Application number	US-201916967395-A
Country	US
Kind code	B2
Filing date	Feb 11, 2019
Priority date	Feb 9, 2018
Publication date	Jun 20, 2023
Grant date	Jun 20, 2023

Abstract

A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.

First claim

What is claimed is:

1. A bioprinter for manufacturing an organomimetic device, the bioprinter comprising:
at least one extruder;
a three-dimensional movement assembly;
a build-plate wherein the build-plate comprises a UV crosslinking light source; and
a controller configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate.

2. The bioprinter of claim 1 , wherein the at least one extruder comprises a multi-way valve the multi-way valve having a first position and a second position, the first position for printing and the second position to for refilling the at least one extruder.

3. The bioprinter of claim 1 , wherein the at least one extruder comprises a UV crosslinking light source.

4. The bioprinter of claim 1 , wherein the at least one extruder is configured to extrude a material and Wherein the material comprises a first material and a second material printed in tandem wherein the first material solidifies above 4 degrees Celsius and is liquid below 4 degrees Celsius and the second material is a solid to semi-solid below 37 degrees Celsius and a liquid above 37 degrees Celsius.

5. The bioprinter of claim 1 , wherein the at least one extruder comprises a first extruder and a second extruder and the first extruder and second extruder are coaxial.

6. The bioprinter of claim 1 , wherein the at least one extruder is non-movably fixed to a cabinet and the bioprinter further comprising holes, perforations, or apertures to enable a vacuum to be drawn within one or more compartments defined by the cabinet.

7. The bioprinter of claim 6 , wherein the cabinet comprises a first compartment, a second compartment, and a third compartment, the first compartment comprising a first access door and the three-dimensional movement assembly is disposed in the first compartment, the second compartment comprises a second access door and the at least one extruder is disposed in the second compartment and the controller is disposed in the third compartment.

8. The bioprinter of claim 1 , wherein the three-dimensional movement assembly comprises three linear stages: an x-axis stage, a y-axis stage, and a z-axis stage and the x-axis stage comprises an x-axis carriage, the y-axis stage comprises a y-axis carriage, and the z-axis stage comprises a z-axis carriage and the x-axis carriage is configured to move the z-axis carriage Wherein the x-axis stage has a 300 millimeter stroke length, the y-axis stage has a 200 millimeter stroke length, and the z-axis stage has a 100 millimeter stroke length.

9. The bioprinter of claim 8 , wherein the stroke lengths define the end-to-end travel distance of the x-axis carriage, y-axis carriage and z-axis carriage.

10. The bioprinter of claim 1 , wherein the three-dimensional movement assembly comprises an embedded mechanical limit switch.

11. The bioprinter of claim 1 , wherein the at least one extruder is mounted to a cabinet via a mounting bracket and further comprising a second build-plate oriented perpendicular to the at least one extruder mounting bracket.

12. The bioprinter of claim 1 , wherein the build-plate is moveable relative to the at least one extruder and the at least one extruder is moveable relative to the build-plate.

13. A bioprinter for manufacturing an organomimetic device, the bioprinter comprising:
at least one extruder;
a three-dimensional movement assembly; and
a build-plate wherein the build-plate comprises a UV crosslinking light source at each of the build-plate's four corners.

14. A bioprinter for manufacturing an organomimetic device, the bioprinter comprising:
at least one first extruder;
a three-dimensional movement assembly;
a first build-late and a second build-plate oriented anti-parallel to the first build-plate in the axis; and

a controller configured to control the at least one first extruder, the three-dimensional movement assembly, the first build-plate and the second build-plate.

15. The bioprinter of claim 14 , wherein the at least one first extruder is mounted to a first wall of a cabinet and further comprising a second extruder mounted to a second wall of the cabinet wherein the first wall and second wall are opposite each other.

16. The bioprinter of claim 6 , wherein the second extruder and the at least one first extruder are two independent extruder systems.

17. The bioprinter of claim 15 , wherein when the second extruder is lowered the at least one first extruder is raised.

Assignees

• Univ Colorado Regents

Inventors

• Benam Kambez
• Kaiser Alexander

Classifications

• C12M21/08

  for producing artificial tissue or for ex-vivo cultivation of tissue (prostheses A61F2/00, grafts A61L27/00) · CPC title

• B29C64/245

  Platforms or substrates (support structures intended to be sacrificed after manufacture B29C64/40) · CPC title

• B29C64/236

  for motion in a direction within the plane of a layer · CPC title

• B33Y70/00

  Materials specially adapted for additive manufacturing · CPC title

• B33Y50/02

  for controlling or regulating additive manufacturing processes · CPC title