Systems and methods for burst waveforms with anodic-leading pulses

Patent metadata

Field	Value
Publication number	US-11679264-B2
Application number	US-202017082299-A
Country	US
Kind code	B2
Filing date	Oct 28, 2020
Priority date	Sep 9, 2020
Publication date	Jun 20, 2023
Grant date	Jun 20, 2023

Abstract

The present disclosure provides systems and methods for generating burst waveforms. An implantable neurostimulation system includes an implantable stimulation lead including a plurality of contacts, and an implantable pulse generator communicatively coupled to the stimulation lead. The pulse generator is configured to generate a waveform including a burst that includes a leading anodic pulse followed by alternating cathodic pulses and anodic pulses, each cathodic pulse in the burst having a greater amplitude than the previous cathodic pulse.

First claim

What is claimed is:

1. An implantable neurostimulation system for generating burst waveforms, the neurostimulation system comprising:
an implantable stimulation lead comprising a plurality of contacts; and
an implantable pulse generator communicatively coupled to the stimulation lead and configured to:
generate a waveform including a burst that includes a leading anodic pulse followed by alternating square wave cathodic pulses and anodic pulses, each square wave cathodic pulse in the burst having a greater amplitude than the previous cathodic square wave pulse.

2. The implantable neurostimulation system of claim 1 , wherein the burst further includes a passive discharge following a last square wave cathodic pulse, the passive discharge decaying from a positive value to zero.

3. The implantable neurostimulation system of claim 1 , wherein the leading anodic pulse and the subsequent anodic pulses have a same pulse width and amplitude, and wherein a total number of anodic pulses within the burst is in a range from two to eight pulses.

4. The implantable neurostimulation system of claim 1 , wherein a pulse width of the leading anodic pulse is greater than a pulse width of the square wave cathodic pulses, and wherein the pulse width of the leading anodic pulse is between 400 μs and 1000 μs.

5. The implantable neurostimulation system of claim 1 , wherein the burst further includes an inter-phase gap between each anodic and square wave cathodic pulse.

6. The implantable neurostimulation system of claim 1 , wherein a charge output by the leading anodic pulse is less than or equal to a charge output by a first square wave cathodic pulse.

7. The implantable neurostimulation system of claim 1 , wherein an amplitude of the leading anodic pulse is in a range from 12.5% to 50% of an amplitude of a first square wave cathodic pulse.

8. An implantable pulse generator for generating burst waveforms, the pulse generator comprising:
a memory device; and
a processor coupled to the memory device, the processor configured to generate a waveform including a burst that includes a leading anodic pulse followed by alternating cathodic square wave pulses and anodic pulses, each square wave cathodic pulse in the burst having a greater amplitude than the previous square wave cathodic pulse.

9. The implantable pulse generator of claim 8 , wherein the burst further includes a passive discharge following a last square wave cathodic pulse, the passive discharge decaying from a positive value to zero.

10. The implantable pulse generator of claim 8 , wherein the leading anodic pulse and the subsequent anodic pulses have a same pulse width and amplitude, and wherein a total number of anodic pulses within the burst is in a range from two to eight pulses.

11. The implantable pulse generator of claim 8 , wherein a pulse width of the leading anodic pulse is greater than a pulse width of the square wave cathodic pulses, and wherein the pulse width of the leading anodic pulse is between 400 μs and 1000 μs.

12. The implantable pulse generator of claim 8 , wherein the burst further includes an inter-phase gap between each anodic and square wave cathodic pulse.

13. The implantable pulse generator of claim 8 , wherein a charge output by the leading anodic pulse is less than or equal to a charge output by a first square wave cathodic pulse.

14. The implantable pulse generator of claim 8 , wherein an amplitude of the leading anodic pulse is in a range from 12.5% to 50% of an amplitude of a first square wave cathodic pulse.

15. A method of applying neurostimulation, the method comprising:
generating, using an implantable pulse generator, a waveform including a burst that includes a leading anodic pulse followed by alternating square wave cathodic pulses and anodic pulses, each square wave cathodic pulse in the burst having a greater amplitude than the previous square wave cathodic pulse; and
applying the waveform to a patient using an implantable stimulation lead coupled to the implantable pulse generator.

16. The method of claim 15 , wherein the burst further includes a passive discharge following a last square wave cathodic pulse.

17. The method of claim 15 , wherein the leading anodic pulse and the subsequent anodic pulses have a same pulse width and amplitude, and wherein a total number of anodic pulses within the burst is in a range from two to eight pulses.

18. The method of claim 15 , wherein a pulse width of the leading anodic pulse is greater than a pulse width of the square wave cathodic pulses, and wherein the pulse width of the leading anodic pulse is between 400 μs and 1000 μs.

19. The method of claim 15 , wherein the burst further includes an inter-phase gap between each anodic and square wave cathodic pulse.

20. The method of claim 15 , wherein a charge output by the leading anodic pulse is less than or equal to a charge output by a first square wave cathodic pulse.

Assignees

• Advanced Neuromodulation Systems Inc

Inventors

• Zhang Simeng
• Park Hyun-Joo
• Agnesi Filippo
• Pathak Yagna
• Ross Erika

Classifications

• A61N1/36071

  Pain · CPC title

• A61N1/36175

  Pulse width or duty cycle · CPC title

• A61N1/0551

  Spinal or peripheral nerve electrodes · CPC title

• A61N1/36178 Primary

  Burst or pulse train parameters · CPC title

• A61N1/36157 Primary

  Current (A61N1/3616 takes precedence) · CPC title