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Caspase-3-triggered molecular self-assembling PET probes and uses thereof
US11679168B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11679168-B2 |
| Application number | US-201916570228-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 13, 2019 |
| Priority date | Sep 14, 2018 |
| Publication date | Jun 20, 2023 |
| Grant date | Jun 20, 2023 |
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- Title
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- Abstract
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Abstract
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Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.
First claim
Opening claim text (preview).
What is claimed: 1. A compound having formula: 2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier. 3. A method of imaging nanoaggregates in a subject, the method comprising: (i) administer to the subject a compound having formula: and (ii) obtaining an image of the nanoaggregates in the subject.
Assignees
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Classifications
the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu · CPC title
with the first amino acid being acidic · CPC title
- A61K51/088Primary
conjugates with carriers being peptides, polyamino acids or proteins (antibodies A61K51/10) · CPC title
Peptides, proteins, polyamino acids · CPC title
Methine dyes, e.g. cyanine dyes · CPC title
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- What does patent US11679168B2 cover?
- Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclo…
- Who is the assignee on this patent?
- Univ Leland Stanford Junior, The Board Of Trustees Of Leland Stanford Junior Univ
- What technology area does this patent fall under?
- Primary CPC classification A61K51/088. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).