Use of stable isotopes to prove authentication of manufacturing location

Patent metadata

Field	Value
Publication number	US-11679156-B2
Application number	US-201816873560-A
Country	US
Kind code	B2
Filing date	Nov 1, 2018
Priority date	Nov 2, 2017
Publication date	Jun 20, 2023
Grant date	Jun 20, 2023

Abstract

The disclosure relates to a manufactured composition, material or device comprising at least two different nonradioactive isotope atoms. Each nonradioactive isotope atom is present in an amount sufficient to increase the total amount of the nonradioactive isotope atom above the total amount found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount. The ratio(s) of the at least two nonradioactive isotopes in the manufactured composition, material or device are measurably different than the ratio(s) found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount.

First claim

What is claimed is:

1. A manufactured composition, material or device, or an agricultural product comprising at least two different nonradioactive isotope atoms,
a) wherein each nonradioactive isotope atom is present in an amount sufficient to increase the total amount of the nonradioactive isotope atom above the total amount found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount, and
b) wherein the ratio(s) of the at least two nonradioactive isotopes in the manufactured composition, material or device are measurably different than the ratio(s) found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount,

wherein the at least two different nonradioactive isotope atoms are present in the manufactured composition, material or device as part of an additional component or constituent added to the manufactured composition, material or device, or the agricultural product, and
wherein the additional component is a label, an ink printing, a blister pack comprising a gas mixture comprising the at least two different nonradioactive isotope atoms, or combinations of the foregoing.

2. The manufactured composition, material or device, or the agricultural product of claim 1 , wherein the at least two different nonradioactive isotope atoms are present in the manufactured composition, material or device, or the agricultural product, in the place of other isotopes of the same atoms of the manufactured composition, material or device, or the agricultural product.

3. The manufactured composition, material or device, or the agricultural product of claim 1 , wherein the at least two different nonradioactive isotope atoms are present in the manufactured composition, material or device as part of an additional component or constituent added to the manufactured composition, material or device, or the agricultural product.

4. The manufactured composition, material or device of claim 3 , wherein the additional component is a label, an ink printing, a blister pack comprising a gas mixture comprising the at least two different nonradioactive isotope atoms, or combinations of the foregoing.

5. The manufactured composition, material or device, or the agricultural product of claim 1 , wherein the manufactured composition, material or device, or the agricultural product, is a manufactured pharmaceutical product, a manufactured nutraceutical product, a manufactured chemical intermediate suitable for use in producing other products, or combinations of the foregoing.

6. The manufactured composition of claim 1 , wherein each of the at least two nonradioactive isotope atoms are selected from deuterium (2D or 2H, hydrogen isotope), helium-3 (3He), carbon-13 (13C), nitrogen-15 (15N), oxygen-17 (17O), oxygen-18 (180), fluorine-19 (19F), neon-21 (2Ne), sulfur-33 (33S), sulfur-36 (36S), argon-36 (36Ar), argon-38 (38Ar), potassium-40 (40K), calcium-42 (42Ca), calcium-43 (43Ca), calcium-46 (46Ca), calcium-48 (48Ca), iron-58 (58Fe), nickel-64 (64Ni), zinc-70 (70Zn), selenium-74 (74Se), krypton-78 or 80 (78Kr, 80Kr), strontium-84 (84Sr) and Xenon-124, 126, 128, 129, 130, 131, 132 or 134 (124Xe, etc.).

7. An authentication method comprising at least a first isotope and a second isotope, wherein the first isotope and the second isotope have a predetermined relative mass ratio, wherein the predetermined relative mass ratio is different from the naturally occurring mass ratio, the method comprising incorporating the at least first isotope and the second isotope within a material during the production of the material, wherein the at least first isotope and the second isotope are added to the material during production.

8. The method of claim 7 , wherein the material is a pharmaceutical.

9. The method of claim 7 , wherein the material is a neutraceutical.

10. The method of claim 7 , wherein the material is a chemical intermediary.

11. The method of claim 7 , wherein the at least first isotope and the second isotope are added to the material before the completion of production.

12. The method of claim 7 , wherein the material is a living organism.

13. The method of claim 7 , wherein the material is a plant.

14. The method of claim 7 , wherein the material is a botanical.

15. The method of claim 7 , wherein the living organism/plant is at least partially grown in the presence of the at least first isotope and the second isotope.

16. The method of claim 7 , wherein the at least first isotope and second isotope are added to a modified carbon dioxide atmosphere, in which the plant is at least partially grown.

17. The method of claim 7 , wherein the at least first isotope and second isotope are added to a modified fertilizer, with which the plant is at least partially fed.

18. The method of claim 7 , wherein the at least first isotope and second isotope are added to a modified soil, in which the plant is at least partially grown.

19. The method of claim 7 , wherein the material is cell expression.

Assignees

• Jacksier Tracey
• Matthew Mani
• Reccek Jr Anthony W
• Vasarhelyi Martin
• Omarjee Vincent M
• Air Liquide
• Air Liquide American
• Airgas Inc

Inventors

• Jacksier Tracey
• Matthew Mani
• Reccek Jr Anthony W
• Vasarhelyi Martin
• Omarjee Vincent M

Classifications

• G01N33/0098

  Plants or trees (wood G01N33/46) · CPC title

• G01N33/15

  Medicinal preparations {; Physical properties thereof, e.g. dissolubility} · CPC title

• A61K47/02 Primary

  Inorganic compounds · CPC title

• G01N2033/0093

  Physics · mapped topic

• G01N33/32

  Paints; Inks · CPC title