Method, apparatus, and computer program product for controlling components of a detection device

Patent metadata

Field	Value
Publication number	US-11673141-B2
Application number	US-202117474544-A
Country	US
Kind code	B2
Filing date	Sep 14, 2021
Priority date	Apr 20, 2017
Publication date	Jun 13, 2023
Grant date	Jun 13, 2023

Abstract

A method, computer program product, and apparatus are provided for controlling components of a detection device. The device may detect turbidity of liquid with sensors such as a density sensor and/or nephelometric sensor. A light modulation pattern may reduce or eliminate interference in sensor readings. Readings may be performed during off cycles of an illumination light to reduce interference but to provide improved visibility of a tube. Dark and light sensor readings may be performed with an emitter respectively off or on to account for ambient light in subsequent readings. Readings from the density sensor and/or nephelometric sensor may be used to calculate McFarland values. The device may be zeroed based on an emitter level that results in a sensor reading satisfying a predetermined criterion.

First claim

The invention claimed is:

1. An apparatus for reducing light interference during testing contents of a sample tube, the apparatus comprising:
a shell defining one or more cavities for receiving at least a portion of a sample tube;
an illumination light for illuminating the sample tube with visible light for a plurality of illumination light activation periods;
an emitter configured to emit a source light towards the sample tube; and
one or more sensors configured to receive at least a portion of the emitted source light during a plurality of sensor reading periods,
wherein the plurality of illumination light activation periods and the plurality of sensor reading periods are configured to be sequenced such that, for at least a period of time, the illumination light and the one or more sensors appear to be simultaneously illuminating the sample tube and receiving at least a portion of the emitted source light, respectively, while the plurality of illumination light activation periods and the plurality of sensor reading periods do not overlap.

2. The apparatus of claim 1 , wherein a first sensor reading period of the plurality of sensor reading periods is initiated based at least in part on receipt of the sample tube in a cavity of the one or more cavities of the shell.

3. The apparatus of claim 2 , wherein the cavity comprises a physical switch that is triggered by the sample tube in the cavity thereby indicating insertion of the sample tube in the cavity.

4. The apparatus of claim 2 , wherein the apparatus further comprises a user interface and the receipt of the sample tube in the cavity is based on user input to the user interface indicating insertion of the sample tube in the cavity.

5. The apparatus of claim 1 , wherein the plurality of illumination light activation periods are alternated in time with a plurality of illumination light inactivation periods.

6. The apparatus of claim 5 , wherein each of the plurality of illumination light inactivation periods defines a duration less than 21 ms.

7. The apparatus of claim 1 , wherein the illumination light is configured to allow at least a portion of contents of the sample tube to be observable by a user outside the apparatus during a testing of the contents.

8. A method for operating an optical testing instrument to reduce light interference from an illumination light in sensor readings, the method comprising:
receiving an indication of a sample tube insertion;
causing an illumination light to illuminate the inserted sample tube with visible light during each of a plurality of illumination light activation periods;
controlling an emitter to emit a signal towards the sample tube for detection by one or more sensors; and
receiving at least a portion of the emitted source light with the one or more sensors during a plurality of sensor reading periods, wherein a first sensor reading period of the plurality of sensor reading periods is based at least in part on the receipt of the indication of the sample tube insertion,
wherein the plurality of illumination light activation periods and the plurality of sensor reading periods are configured to be sequenced such that, for at least a period of time, the illumination light and the one or more sensors appear to be simultaneously illuminating the sample tube and receiving at least a portion of the emitted source light, respectively, while the plurality of illumination light activation periods and the plurality of sensor reading periods do not overlap.

9. The method of claim 8 , wherein the first sensor reading period of the plurality of sensor reading periods begins following completion of a predetermined initial delay after the receipt of the indication of the sample tube insertion.

10. The method of claim 8 , wherein the indication of the sample tube insertion is based on a triggering of a physical switch.

11. The method of claim 8 , wherein the plurality of illumination light activation periods are alternated in time with a plurality of illumination light inactivation periods.

12. The method of claim 11 , wherein the method further comprises:
during at least one illumination light inactivation period of the plurality of illumination light inactivation periods, controlling the emitter to emit a signal during an emitter activation period,
wherein the emitter activation period begins following completion of a predetermined emitter time delay, the predetermined emitter time delay triggered by expiration of the illumination light activation period immediately preceding in time the at least one illumination light inactivation period.

13. The method of claim 12 , wherein the method further comprises:
controlling at least one sensor of the one or more sensors to perform a first sensor reading following completion of a predetermined sensor time delay, the predetermined sensor time delay triggered by expiration of the illumination light activation period.

14. The method of claim 13 , wherein the predetermined sensor time delay is less than the predetermined emitter time delay such that the first sensor reading is a dark reading performed during the predetermined emitter time delay and the at least one illumination light inactivation period.

15. The method of claim 14 , wherein the method further comprises:
controlling the at least one sensor of the one or more sensors to perform a second sensor reading,
wherein the second sensor reading is performed during the emitter activation period such that the second sensor reading is a light reading.

16. The method of claim 15 , wherein the method further comprises:
determining an ambient light offset value for the at least one sensor, the ambient light offset value of the at least one sensor based on subtracting the first sensor reading from the second sensor reading; and
calibrating subsequent sensor readings of the at least one sensor according to the ambient light offset value.

17. The method of claim 8 , wherein the illumination light is configured to allow at least a portion of contents of the inserted sample tube to be observable by a user outside the optical testing instrument during a testing of the contents.

18. The method of claim 8 , wherein the one or more sensors comprise at least one density sensor and at least one nephelometric sensor, the method further comprising:
detecting a sensor error in at least one sensor of the one or more sensors based on a comparison of density sensor readings and nephelometric sensor readings.

19. The method of claim 18 , wherein detecting the sensor error in at least one sensor of the one or more sensors comprises:
detecting at least one variation or abnormal sensor reading performed by a first sensor relative to sensor readings performed by a second sensor in comparison to a pattern of past density sensor readings, past nephelometric sensor readings, or combination of past density sensor readings and past nephelometric sensor readings relative to each other.

20. An apparatus for reducing light interference during testing contents of a sample tube, the apparatus comprising:
means for receiving at least a portion of a sample tube;
means for illuminating the sample tube with visible light for a plurality of illumination periods;
means for emitting a source light towards the sample tube; and
means for receiving at least a portion of the emitted source light during a plurality of reading periods,
wherein the plurality of illumination periods and the plurality of reading periods are configured to be sequenced such that, for at l

Assignees

• Bio Merieux Inc

Inventors

• Harrison Joel Patrick
• Korte John Kenneth
• Price Jeffrey Edward

Classifications

• G01N2021/0389

  Windows · CPC title

• G01N33/487

  of liquid biological material · CPC title

• G01N21/4738

  Diffuse reflection (precedence is given to G01N21/55 - G01N21/57 if specular component is taken into consideration), e.g. also for testing fluids, fibrous materials · CPC title

• G01N21/93

  Detection standards; Calibrating {baseline adjustment, drift correction} · CPC title

• G01N21/51

  inside a container, e.g. in an ampoule (G01N21/53 takes precedence) · CPC title