Materials and methods for suppressing and/or treating bone related diseases and symptoms

Patent metadata

Field	Value
Publication number	US-11672811-B2
Application number	US-201816635769-A
Country	US
Kind code	B2
Filing date	Aug 2, 2018
Priority date	Aug 2, 2017
Publication date	Jun 13, 2023
Grant date	Jun 13, 2023

Abstract

Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistance to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.

First claim

We claim:

1. A compound, comprising:
A-Y—B,

wherein:
A is

and X is selected from the group consisting of: H and

Y is a linker of formula NR 1 ;

R′ is H, CH 3 , alkyl, halogen, CF 3 , CN, OH, OCH 3 , or O-alkyl;
wherein R 1 is NR 2 R 3 , NR 2 S(═O) 2 R 3 or R 2 OR 3 ;
R 2 and R 3 are independently selected from H, C 1 -C 10 alkyl, C 1 -C 10 alkoxy, C 6 H 5 OR 4 , and wherein R 2 and R 3 are not both H,
R 4 is C 1 -C 10 alkyl, C 1 -C 10 alkoxy, carbonyl, or amide; and
B is at least one bisphosphonate optionally substituted with OH, halogen, CH 3 , NH 2 ,

or a pharmaceutically acceptable salt thereof.

2. A compound comprising one or more stereoisomers of the formula:

wherein:
′R is H, CH 3 , alkyl, halogen, CF 3 , CN, OH, OCH 3 , or O-alkyl;
n is 1-9;
m is 0-7; and
X is H, OH, halogen, CH 3 , NH 2 , N-alkyl, or N-dialkyl;
or a pharmaceutically acceptable salt.

3. The compound according to claim 2 , wherein n is 1-3, m is 0, and X is H.

4. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

5. The compound according to according to claim 2 , wherein the one or more stereoisomers comprise any one or more of the formula:

Assignees

• Univ Indiana Res & Tech Corp
• Univ Rochester
• The Us Department Of Veterans Affairs Office Of General
• The Us Department Of Veteranas Affairs

Inventors

• Bellido Teresita M
• Roodman G David
• Delgado-Calle Jesus
• Boeckman Robert K
• Ebetino Frank H

Classifications

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K47/548

  Phosphates or phosphonates, e.g. bone-seeking (phospholipids A61K47/544) · CPC title

• C07C235/00

  Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms · CPC title

• A61K38/29

  Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides · CPC title

• C07C237/06

  having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms · CPC title