Compounds and their use

Patent metadata

Field	Value
Publication number	US-11667602-B2
Application number	US-202117457953-A
Country	US
Kind code	B2
Filing date	Dec 7, 2021
Priority date	Dec 8, 2020
Publication date	Jun 6, 2023
Grant date	Jun 6, 2023

Abstract

The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where A, U, V, W, X, Y, Z, R1, R2, R3, R4 and R5 have the meanings defined herein. Such compounds are modulators of RXFP1 and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions including heart failure, heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury. The specification further relates to compositions comprising such compounds, intermediates useful in processes for preparing such compounds, and processes for preparing such compounds using such intermediates.

First claim

The invention claimed is:

1. A compound which is

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

3. The compound of claim 1 , which is

4. The compound of claim 1 , which is a pharmaceutically acceptable salt of

5. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable excipient.

6. A pharmaceutical composition comprising the compound of claim 4 and a pharmaceutically acceptable excipient.

Assignees

• Astrazeneca Ab
• Mitsubishi Tanabe Pharma Corp

Inventors

• Granberg Kenneth Lars
• Sakamaki Shigeki
• Fuchigami Ryuichi
• Niwa yasuki
• Fujio Masakazu
• Bergström Hans Fredrik
• Boström Stig Jonas

Classifications

• C07D263/40

  attached in position 4 · CPC title

• C07D275/02

  not condensed with other rings · CPC title

• C07C2602/42

  the bicyclo ring system containing seven carbon atoms · CPC title

• C07D241/12

  with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms · CPC title

• C07D307/24

  Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen · CPC title